The Present and Future Role of Microfluidics for Protein and Peptide-Based Therapeutics and Diagnostics
The implementation of peptide-based molecules within the medical field has vast potential, owing to their unique nature and predictable physicochemical profiles. However, peptide therapeutic usage is hindered by delivery-related challenges, meaning that their formulations must be altered to overcome...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/9/4109 |
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| author | Edward Weaver Shahid Uddin David K. Cole Andrew Hooker Dimitrios A. Lamprou |
| author_facet | Edward Weaver Shahid Uddin David K. Cole Andrew Hooker Dimitrios A. Lamprou |
| author_sort | Edward Weaver |
| collection | DOAJ |
| description | The implementation of peptide-based molecules within the medical field has vast potential, owing to their unique nature and predictable physicochemical profiles. However, peptide therapeutic usage is hindered by delivery-related challenges, meaning that their formulations must be altered to overcome these limitations. This process could be propelled by applying microfluidics (MFs) due to its highly controllable and adaptable attributes; however, therapeutic research within this field is extremely limited. Peptides possess multifunctional roles within therapeutic formulations, ranging from enhancing target specificity to acting as the active component of the medicine. Diagnostically, MFs are well explored in the field of peptides, as MFs provide an unsullied platform to provide fast yet accurate examinations. The capacity to add attributes, such as integrated sensors and microwells, to the MF chip, only enhances the attractiveness of MFs as a diagnostic platform. The structural individuality of peptides makes them prime candidates for diagnostic purposes, for example, antigen detection and isolation. Therefore, this review provides a useful insight into the current applications of MFs for peptide-based therapy and diagnostics and highlights potential gaps in the field that are yet to be explored or optimized. |
| first_indexed | 2024-03-10T11:47:52Z |
| format | Article |
| id | doaj.art-15e986f74ca94a65a147b2ecdaa3b047 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T11:47:52Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj.art-15e986f74ca94a65a147b2ecdaa3b0472023-11-21T17:55:36ZengMDPI AGApplied Sciences2076-34172021-04-01119410910.3390/app11094109The Present and Future Role of Microfluidics for Protein and Peptide-Based Therapeutics and DiagnosticsEdward Weaver0Shahid Uddin1David K. Cole2Andrew Hooker3Dimitrios A. Lamprou4School of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKImmunocore Ltd., 92 Park Drive, Milton Park, Abingdon OX14 4RY, UKImmunocore Ltd., 92 Park Drive, Milton Park, Abingdon OX14 4RY, UKImmunocore Ltd., 92 Park Drive, Milton Park, Abingdon OX14 4RY, UKSchool of Pharmacy, Queen’s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UKThe implementation of peptide-based molecules within the medical field has vast potential, owing to their unique nature and predictable physicochemical profiles. However, peptide therapeutic usage is hindered by delivery-related challenges, meaning that their formulations must be altered to overcome these limitations. This process could be propelled by applying microfluidics (MFs) due to its highly controllable and adaptable attributes; however, therapeutic research within this field is extremely limited. Peptides possess multifunctional roles within therapeutic formulations, ranging from enhancing target specificity to acting as the active component of the medicine. Diagnostically, MFs are well explored in the field of peptides, as MFs provide an unsullied platform to provide fast yet accurate examinations. The capacity to add attributes, such as integrated sensors and microwells, to the MF chip, only enhances the attractiveness of MFs as a diagnostic platform. The structural individuality of peptides makes them prime candidates for diagnostic purposes, for example, antigen detection and isolation. Therefore, this review provides a useful insight into the current applications of MFs for peptide-based therapy and diagnostics and highlights potential gaps in the field that are yet to be explored or optimized.https://www.mdpi.com/2076-3417/11/9/4109microfluidicspeptidesproteinsamino acid-based biologicstheranosticsformulation |
| spellingShingle | Edward Weaver Shahid Uddin David K. Cole Andrew Hooker Dimitrios A. Lamprou The Present and Future Role of Microfluidics for Protein and Peptide-Based Therapeutics and Diagnostics Applied Sciences microfluidics peptides proteins amino acid-based biologics theranostics formulation |
| title | The Present and Future Role of Microfluidics for Protein and Peptide-Based Therapeutics and Diagnostics |
| title_full | The Present and Future Role of Microfluidics for Protein and Peptide-Based Therapeutics and Diagnostics |
| title_fullStr | The Present and Future Role of Microfluidics for Protein and Peptide-Based Therapeutics and Diagnostics |
| title_full_unstemmed | The Present and Future Role of Microfluidics for Protein and Peptide-Based Therapeutics and Diagnostics |
| title_short | The Present and Future Role of Microfluidics for Protein and Peptide-Based Therapeutics and Diagnostics |
| title_sort | present and future role of microfluidics for protein and peptide based therapeutics and diagnostics |
| topic | microfluidics peptides proteins amino acid-based biologics theranostics formulation |
| url | https://www.mdpi.com/2076-3417/11/9/4109 |
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