The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome
Background: Green coffee seed (Coffea canephora) are rich in polyphenolic compounds and yellow turmeric (Curcuma domestica val.) is rich in curcuminoids and essential oils. This study determined the combination effect of green coffee seed and yellow turmeric extracts on TNF-α in acute respiratory di...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2022-12-01
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| Series: | International Journal of Nutrition Sciences |
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| Online Access: | https://ijns.sums.ac.ir/article_48923_d5c1f1e080e65e1652d6eaee60b70a53.pdf |
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| author | Catur Lestari Restu Ayu Eka Pustika Dewi Siti Nurjanah Lusiana Cici Sabarani Fibra Resputri |
| author_facet | Catur Lestari Restu Ayu Eka Pustika Dewi Siti Nurjanah Lusiana Cici Sabarani Fibra Resputri |
| author_sort | Catur Lestari |
| collection | DOAJ |
| description | Background: Green coffee seed (Coffea canephora) are rich in polyphenolic compounds and yellow turmeric (Curcuma domestica val.) is rich in curcuminoids and essential oils. This study determined the combination effect of green coffee seed and yellow turmeric extracts on TNF-α in acute respiratory distress syndrome (ARDS) in rat model.Methods: Thirty rats were randomly grouped into five equal groups of 5 rats. Control group received normal diet and distilled water, positive control was administered with 0.8 mg/kg of LPS to induce ARDS in absence of any treatment, Treatment group 1 received 200 mg/kg/day of the combination of green coffe seed and yellow tumeric extract intraperitoneally (IP) for 14 days, Treatment group 2 was given 400 mg/kg/day of the combination similarly, and treatment group 3 was injected with 600 mg/kg/day of the combination identically. TNF-α level wascompared between groups.Results: The combination of green coffee seed and yellow turmeric extract (400 mg/kg/day) given for 14 days could significantly decrease TNF-α level in rats after induction of ARDS (p˂0.05).Conclusion: A combination of green coffee seed (C. canephora) and yellow turmeric (C. domestica Val.) extract can be considered a therapeutic choice in ARDS. |
| first_indexed | 2024-04-10T16:42:53Z |
| format | Article |
| id | doaj.art-15ea738f39f143579aebfbcaa4e94f72 |
| institution | Directory Open Access Journal |
| issn | 2538-1873 2538-2829 |
| language | English |
| last_indexed | 2024-04-10T16:42:53Z |
| publishDate | 2022-12-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | International Journal of Nutrition Sciences |
| spelling | doaj.art-15ea738f39f143579aebfbcaa4e94f722023-02-08T04:56:41ZengShiraz University of Medical SciencesInternational Journal of Nutrition Sciences2538-18732538-28292022-12-017421021610.30476/ijns.2022.97406.120948923The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress SyndromeCatur Lestari0Restu Ayu Eka Pustika Dewi1Siti Nurjanah2Lusiana Cici Sabarani3Fibra Resputri4Department of Biomedical Science, Faculty of Health, Ivet University, Central Java , IndonesiaDepartment of Biomedical Science, Faculty of Health, Ivet University, Central Java , IndonesiaStudent Program of Biomedical Science, Faculty of Health, Ivet University, Central Java, IndonesiaStudent Program of Biomedical Science, Faculty of Health, Ivet University, Central Java, IndonesiaStudent Program of Biomedical Science, Faculty of Health, Ivet University, Central Java, IndonesiaBackground: Green coffee seed (Coffea canephora) are rich in polyphenolic compounds and yellow turmeric (Curcuma domestica val.) is rich in curcuminoids and essential oils. This study determined the combination effect of green coffee seed and yellow turmeric extracts on TNF-α in acute respiratory distress syndrome (ARDS) in rat model.Methods: Thirty rats were randomly grouped into five equal groups of 5 rats. Control group received normal diet and distilled water, positive control was administered with 0.8 mg/kg of LPS to induce ARDS in absence of any treatment, Treatment group 1 received 200 mg/kg/day of the combination of green coffe seed and yellow tumeric extract intraperitoneally (IP) for 14 days, Treatment group 2 was given 400 mg/kg/day of the combination similarly, and treatment group 3 was injected with 600 mg/kg/day of the combination identically. TNF-α level wascompared between groups.Results: The combination of green coffee seed and yellow turmeric extract (400 mg/kg/day) given for 14 days could significantly decrease TNF-α level in rats after induction of ARDS (p˂0.05).Conclusion: A combination of green coffee seed (C. canephora) and yellow turmeric (C. domestica Val.) extract can be considered a therapeutic choice in ARDS.https://ijns.sums.ac.ir/article_48923_d5c1f1e080e65e1652d6eaee60b70a53.pdfgreen coffee beanyellow turmerictnf-αrespiratory distress syndrome (ards)rat |
| spellingShingle | Catur Lestari Restu Ayu Eka Pustika Dewi Siti Nurjanah Lusiana Cici Sabarani Fibra Resputri The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome International Journal of Nutrition Sciences green coffee bean yellow turmeric tnf-α respiratory distress syndrome (ards) rat |
| title | The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome |
| title_full | The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome |
| title_fullStr | The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome |
| title_full_unstemmed | The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome |
| title_short | The Effect of Green Coffee Seed (Coffea Canephora)and Yellow Turmeric (Curcuma Domestica Val.) Extract on TNF-α Level in Acute Respiratory Distress Syndrome |
| title_sort | effect of green coffee seed coffea canephora and yellow turmeric curcuma domestica val extract on tnf α level in acute respiratory distress syndrome |
| topic | green coffee bean yellow turmeric tnf-α respiratory distress syndrome (ards) rat |
| url | https://ijns.sums.ac.ir/article_48923_d5c1f1e080e65e1652d6eaee60b70a53.pdf |
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