Heart-on-a-chip systems with tissue-specific functionalities for physiological, pathological, and pharmacological studies
Recent advances in heart-on-a-chip systems hold great promise to facilitate cardiac physiological, pathological, and pharmacological studies. This review focuses on the development of heart-on-a-chip systems with tissue-specific functionalities. For one thing, the strategies for developing cardiac m...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423003745 |
| _version_ | 1797355193347604480 |
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| author | Bingsong Gu Kang Han Hanbo Cao Xinxin Huang Xiao Li Mao Mao Hui Zhu Hu Cai Dichen Li Jiankang He |
| author_facet | Bingsong Gu Kang Han Hanbo Cao Xinxin Huang Xiao Li Mao Mao Hui Zhu Hu Cai Dichen Li Jiankang He |
| author_sort | Bingsong Gu |
| collection | DOAJ |
| description | Recent advances in heart-on-a-chip systems hold great promise to facilitate cardiac physiological, pathological, and pharmacological studies. This review focuses on the development of heart-on-a-chip systems with tissue-specific functionalities. For one thing, the strategies for developing cardiac microtissues on heart-on-a-chip systems that closely mimic the structures and behaviors of the native heart are analyzed, including the imitation of cardiac structural and functional characteristics. For another, the development of techniques for real-time monitoring of biophysical and biochemical signals from cardiac microtissues on heart-on-a-chip systems is introduced, incorporating cardiac electrophysiological signals, contractile activity, and biomarkers. Furthermore, the applications of heart-on-a-chip systems in intelligent cardiac studies are discussed regarding physiological/pathological research and pharmacological assessment. Finally, the future development of heart-on-a-chip toward a higher level of systematization, integration, and maturation is proposed. |
| first_indexed | 2024-03-08T14:07:43Z |
| format | Article |
| id | doaj.art-15ec045db4bb4f868dac3f03c71cdb94 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-08T14:07:43Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-15ec045db4bb4f868dac3f03c71cdb942024-01-15T04:24:01ZengElsevierMaterials Today Bio2590-00642024-02-0124100914Heart-on-a-chip systems with tissue-specific functionalities for physiological, pathological, and pharmacological studiesBingsong Gu0Kang Han1Hanbo Cao2Xinxin Huang3Xiao Li4Mao Mao5Hui Zhu6Hu Cai7Dichen Li8Jiankang He9State Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi’ an, 710049, China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi’ an, 710049, China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi'an Jiaotong University, ChinaState Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi’ an, 710049, China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi’ an, 710049, China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi'an Jiaotong University, ChinaShaanxi Provincial Institute for Food and Drug Control, Xi’ an, 710065, ChinaState Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi’ an, 710049, China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi’ an, 710049, China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi'an Jiaotong University, ChinaState Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi’ an, 710049, China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi’ an, 710049, China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi'an Jiaotong University, China; Corresponding author. State Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi’ an, 710049, China.State Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi’ an, 710049, China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi’ an, 710049, China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi'an Jiaotong University, ChinaState Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi’ an, 710049, China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi’ an, 710049, China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi'an Jiaotong University, ChinaShaanxi Provincial Institute for Food and Drug Control, Xi’ an, 710065, ChinaState Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi’ an, 710049, China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi’ an, 710049, China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi'an Jiaotong University, ChinaState Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi’ an, 710049, China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, Xi’ an, 710049, China; National Innovation Platform (Center) for Industry-Education Integration of Medical Technology, Xi'an Jiaotong University, China; Corresponding author. State Key Laboratory for Manufacturing System Engineering, Xi'an Jiaotong University, Xi’ an, 710049, China.Recent advances in heart-on-a-chip systems hold great promise to facilitate cardiac physiological, pathological, and pharmacological studies. This review focuses on the development of heart-on-a-chip systems with tissue-specific functionalities. For one thing, the strategies for developing cardiac microtissues on heart-on-a-chip systems that closely mimic the structures and behaviors of the native heart are analyzed, including the imitation of cardiac structural and functional characteristics. For another, the development of techniques for real-time monitoring of biophysical and biochemical signals from cardiac microtissues on heart-on-a-chip systems is introduced, incorporating cardiac electrophysiological signals, contractile activity, and biomarkers. Furthermore, the applications of heart-on-a-chip systems in intelligent cardiac studies are discussed regarding physiological/pathological research and pharmacological assessment. Finally, the future development of heart-on-a-chip toward a higher level of systematization, integration, and maturation is proposed.http://www.sciencedirect.com/science/article/pii/S2590006423003745Heart-on-a-chipBiosensingCardiac tissuePhysiological behaviorPathological modelingPharmacological study |
| spellingShingle | Bingsong Gu Kang Han Hanbo Cao Xinxin Huang Xiao Li Mao Mao Hui Zhu Hu Cai Dichen Li Jiankang He Heart-on-a-chip systems with tissue-specific functionalities for physiological, pathological, and pharmacological studies Materials Today Bio Heart-on-a-chip Biosensing Cardiac tissue Physiological behavior Pathological modeling Pharmacological study |
| title | Heart-on-a-chip systems with tissue-specific functionalities for physiological, pathological, and pharmacological studies |
| title_full | Heart-on-a-chip systems with tissue-specific functionalities for physiological, pathological, and pharmacological studies |
| title_fullStr | Heart-on-a-chip systems with tissue-specific functionalities for physiological, pathological, and pharmacological studies |
| title_full_unstemmed | Heart-on-a-chip systems with tissue-specific functionalities for physiological, pathological, and pharmacological studies |
| title_short | Heart-on-a-chip systems with tissue-specific functionalities for physiological, pathological, and pharmacological studies |
| title_sort | heart on a chip systems with tissue specific functionalities for physiological pathological and pharmacological studies |
| topic | Heart-on-a-chip Biosensing Cardiac tissue Physiological behavior Pathological modeling Pharmacological study |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423003745 |
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