Effects of Long Non-Coding RNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer
Although an imbalanced gut microbiome is closely associated with colorectal cancer (CRC), how the gut microbiome affects CRC is not known. Long non-coding RNAs (lncRNAs) can affect important cellular functions such as cell division, proliferation, and apoptosis. The abnormal expression of lncRNAs ca...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/23/5813 |
| _version_ | 1797463526432833536 |
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| author | Shiying Fan Juan Xing Zhengting Jiang Zhilin Zhang Huan Zhang Daorong Wang Dong Tang |
| author_facet | Shiying Fan Juan Xing Zhengting Jiang Zhilin Zhang Huan Zhang Daorong Wang Dong Tang |
| author_sort | Shiying Fan |
| collection | DOAJ |
| description | Although an imbalanced gut microbiome is closely associated with colorectal cancer (CRC), how the gut microbiome affects CRC is not known. Long non-coding RNAs (lncRNAs) can affect important cellular functions such as cell division, proliferation, and apoptosis. The abnormal expression of lncRNAs can promote CRC cell growth, proliferation, and metastasis, mediating the effects of the gut microbiome on CRC. Generally, the gut microbiome regulates the lncRNAs expression, which subsequently impacts the host transcriptome to change the expression of downstream target molecules, ultimately resulting in the development and progression of CRC. We focused on the important role of the microbiome in CRC and their effects on CRC-related lncRNAs. We also reviewed the impact of the two main pathogenic bacteria, <i>Fusobacterium nucleatum</i> and enterotoxigenic <i>Bacteroides fragilis</i>, and metabolites of the gut microbiome, butyrate, and lipopolysaccharide, on lncRNAs. Finally, available therapies that target the gut microbiome and lncRNAs to prevent and treat CRC were proposed. |
| first_indexed | 2024-03-09T17:51:58Z |
| format | Article |
| id | doaj.art-15ee610c185e488481c99323d5c9520a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:51:58Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-15ee610c185e488481c99323d5c9520a2023-11-24T10:39:04ZengMDPI AGCancers2072-66942022-11-011423581310.3390/cancers14235813Effects of Long Non-Coding RNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal CancerShiying Fan0Juan Xing1Zhengting Jiang2Zhilin Zhang3Huan Zhang4Daorong Wang5Dong Tang6Clinical Medical College, Yangzhou University, Yangzhou 225000, ChinaClinical Medical College, Yangzhou University, Yangzhou 225000, ChinaClinical Medical College, Yangzhou University, Yangzhou 225000, ChinaClinical Medical College, Yangzhou University, Yangzhou 225000, ChinaClinical Medical College, Yangzhou University, Yangzhou 225000, ChinaDepartment of General Surgery, Institute of General Surgery, Clinical Medical College, Northern Jiangsu People’s Hospital, Yangzhou University, Yangzhou 225000, ChinaDepartment of General Surgery, Institute of General Surgery, Clinical Medical College, Northern Jiangsu People’s Hospital, Yangzhou University, Yangzhou 225000, ChinaAlthough an imbalanced gut microbiome is closely associated with colorectal cancer (CRC), how the gut microbiome affects CRC is not known. Long non-coding RNAs (lncRNAs) can affect important cellular functions such as cell division, proliferation, and apoptosis. The abnormal expression of lncRNAs can promote CRC cell growth, proliferation, and metastasis, mediating the effects of the gut microbiome on CRC. Generally, the gut microbiome regulates the lncRNAs expression, which subsequently impacts the host transcriptome to change the expression of downstream target molecules, ultimately resulting in the development and progression of CRC. We focused on the important role of the microbiome in CRC and their effects on CRC-related lncRNAs. We also reviewed the impact of the two main pathogenic bacteria, <i>Fusobacterium nucleatum</i> and enterotoxigenic <i>Bacteroides fragilis</i>, and metabolites of the gut microbiome, butyrate, and lipopolysaccharide, on lncRNAs. Finally, available therapies that target the gut microbiome and lncRNAs to prevent and treat CRC were proposed.https://www.mdpi.com/2072-6694/14/23/5813colorectal cancerlncRNAsgut microbiomeregulation |
| spellingShingle | Shiying Fan Juan Xing Zhengting Jiang Zhilin Zhang Huan Zhang Daorong Wang Dong Tang Effects of Long Non-Coding RNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer Cancers colorectal cancer lncRNAs gut microbiome regulation |
| title | Effects of Long Non-Coding RNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer |
| title_full | Effects of Long Non-Coding RNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer |
| title_fullStr | Effects of Long Non-Coding RNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer |
| title_full_unstemmed | Effects of Long Non-Coding RNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer |
| title_short | Effects of Long Non-Coding RNAs Induced by the Gut Microbiome on Regulating the Development of Colorectal Cancer |
| title_sort | effects of long non coding rnas induced by the gut microbiome on regulating the development of colorectal cancer |
| topic | colorectal cancer lncRNAs gut microbiome regulation |
| url | https://www.mdpi.com/2072-6694/14/23/5813 |
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