Characteristics, Thrombus Resolution, and Long-Term Outcomes in Patients with Nonvalvular Atrial Fibrillation and Atrial Thrombus
To assess the prevalence and management of atrial thrombus in patients with nonvalvular atrial fibrillation (NVAF) and identify the risk factors of the nonresolution of atrial thrombus. This single-center retrospective observational study consecutively enrolled patients with NVAF and atrial thrombus...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-04-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296231168097 |
| _version_ | 1797808177099571200 |
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| author | Shu Yang MM Yanjuan Zhang MD Ning Chen MM Jiaojiao Shi MD Weizhu Ju MD Hongwu Chen MD Gang Yang MD Zidun Wang MD Hailei Liu MD Xiaohong Jiang MD Chang Cui MD Minglong Chen MD Mingfang Li MD |
| author_facet | Shu Yang MM Yanjuan Zhang MD Ning Chen MM Jiaojiao Shi MD Weizhu Ju MD Hongwu Chen MD Gang Yang MD Zidun Wang MD Hailei Liu MD Xiaohong Jiang MD Chang Cui MD Minglong Chen MD Mingfang Li MD |
| author_sort | Shu Yang MM |
| collection | DOAJ |
| description | To assess the prevalence and management of atrial thrombus in patients with nonvalvular atrial fibrillation (NVAF) and identify the risk factors of the nonresolution of atrial thrombus. This single-center retrospective observational study consecutively enrolled patients with NVAF and atrial thrombus detected using transesophageal echocardiography (TEE) or cardiac computed tomography angiography (CTA) from January 2012 to December 2020. Patients with prior left atrial appendage (LAA) intervention were excluded. The primary endpoint was the presence of atrial thrombus, while the secondary endpoint was the complete resolution of atrial thrombus. The prevalence of atrial thrombus in patients with NVAF was 1.4%. Ninety patients with atrial thrombus (mean age 62.8 ± 11.9 years and 61.1% men) were finally analyzed. Atrial thrombus was in the LAA in 82 (91.1%) patients. During follow up, 60% of the patients showed complete resolution of atrial thrombus. Congestive heart failure (odds ratio [OR]: 8.94; 95% confidence interval [CI]: 1.67-47.80) and a history of ischemic stroke (OR: 8.28; 95% CI: 1.48-46.42) were independently associated with the risk of the nonresolution of atrial thrombus. The presence of atrial thrombus in patients with NVAF who received anticoagulation therapy is non-negligible. Even in anticoagulated patients, TEE or cardiac CTA might still be needed. Congestive heart failure and a history of ischemic stroke are risk factors of the nonresolution of atrial thrombus. |
| first_indexed | 2024-03-13T06:33:39Z |
| format | Article |
| id | doaj.art-15ef75ff8dce47e7bdf3be0648026356 |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-03-13T06:33:39Z |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-15ef75ff8dce47e7bdf3be06480263562023-06-09T06:33:21ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232023-04-012910.1177/10760296231168097Characteristics, Thrombus Resolution, and Long-Term Outcomes in Patients with Nonvalvular Atrial Fibrillation and Atrial ThrombusShu Yang MMYanjuan Zhang MDNing Chen MMJiaojiao Shi MDWeizhu Ju MDHongwu Chen MDGang Yang MDZidun Wang MDHailei Liu MDXiaohong Jiang MDChang Cui MDMinglong Chen MDMingfang Li MDTo assess the prevalence and management of atrial thrombus in patients with nonvalvular atrial fibrillation (NVAF) and identify the risk factors of the nonresolution of atrial thrombus. This single-center retrospective observational study consecutively enrolled patients with NVAF and atrial thrombus detected using transesophageal echocardiography (TEE) or cardiac computed tomography angiography (CTA) from January 2012 to December 2020. Patients with prior left atrial appendage (LAA) intervention were excluded. The primary endpoint was the presence of atrial thrombus, while the secondary endpoint was the complete resolution of atrial thrombus. The prevalence of atrial thrombus in patients with NVAF was 1.4%. Ninety patients with atrial thrombus (mean age 62.8 ± 11.9 years and 61.1% men) were finally analyzed. Atrial thrombus was in the LAA in 82 (91.1%) patients. During follow up, 60% of the patients showed complete resolution of atrial thrombus. Congestive heart failure (odds ratio [OR]: 8.94; 95% confidence interval [CI]: 1.67-47.80) and a history of ischemic stroke (OR: 8.28; 95% CI: 1.48-46.42) were independently associated with the risk of the nonresolution of atrial thrombus. The presence of atrial thrombus in patients with NVAF who received anticoagulation therapy is non-negligible. Even in anticoagulated patients, TEE or cardiac CTA might still be needed. Congestive heart failure and a history of ischemic stroke are risk factors of the nonresolution of atrial thrombus.https://doi.org/10.1177/10760296231168097 |
| spellingShingle | Shu Yang MM Yanjuan Zhang MD Ning Chen MM Jiaojiao Shi MD Weizhu Ju MD Hongwu Chen MD Gang Yang MD Zidun Wang MD Hailei Liu MD Xiaohong Jiang MD Chang Cui MD Minglong Chen MD Mingfang Li MD Characteristics, Thrombus Resolution, and Long-Term Outcomes in Patients with Nonvalvular Atrial Fibrillation and Atrial Thrombus Clinical and Applied Thrombosis/Hemostasis |
| title | Characteristics, Thrombus Resolution, and Long-Term Outcomes in Patients with Nonvalvular Atrial Fibrillation and Atrial Thrombus |
| title_full | Characteristics, Thrombus Resolution, and Long-Term Outcomes in Patients with Nonvalvular Atrial Fibrillation and Atrial Thrombus |
| title_fullStr | Characteristics, Thrombus Resolution, and Long-Term Outcomes in Patients with Nonvalvular Atrial Fibrillation and Atrial Thrombus |
| title_full_unstemmed | Characteristics, Thrombus Resolution, and Long-Term Outcomes in Patients with Nonvalvular Atrial Fibrillation and Atrial Thrombus |
| title_short | Characteristics, Thrombus Resolution, and Long-Term Outcomes in Patients with Nonvalvular Atrial Fibrillation and Atrial Thrombus |
| title_sort | characteristics thrombus resolution and long term outcomes in patients with nonvalvular atrial fibrillation and atrial thrombus |
| url | https://doi.org/10.1177/10760296231168097 |
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