Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study
Abstract Alpha klotho (α-Klotho) is an anti-aging molecule associated with aging and several diseases. Previous studies have reported inconsistent levels of α-Klotho in smokers. This study aimed to demonstrate serum α-Klotho levels in smokers among the US population. This cross-sectional study recru...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-46698-5 |
| _version_ | 1797630285885472768 |
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| author | Rui Du Xiaoyan Tang Meihua Jiang Shengli Qian Li Yang Xiaoling Tong Wei Huang |
| author_facet | Rui Du Xiaoyan Tang Meihua Jiang Shengli Qian Li Yang Xiaoling Tong Wei Huang |
| author_sort | Rui Du |
| collection | DOAJ |
| description | Abstract Alpha klotho (α-Klotho) is an anti-aging molecule associated with aging and several diseases. Previous studies have reported inconsistent levels of α-Klotho in smokers. This study aimed to demonstrate serum α-Klotho levels in smokers among the US population. This cross-sectional study recruited 11,559 participants (aged 40–79 years; 48.2% males). All data were collected from the 2007–2016 National Health and Nutrition Examination Survey. The study comprised adults with reliable Klotho and smoking questionnaire results. The relationship between smoking and serum α-klotho levels was assessed using multivariate linear regression models after adjusting for potential confounders. We also performed a stratified analysis of clinically important variables. The mean serum α-klotho level among the 11,559 participants was 843.85 pg/mL. After full adjustment, habitual smoking was significantly associated with decreased serum levels of α-klotho level (β = − 34.89; 95% CI − 54.97, − 14.81; P = 0.0013) in the total study population. Furthermore, the stratified analysis indicated that the association was insignificant in the 60–79 age group. Quitting smoking was not significantly associated with serum levels of α-klotho as expected (P = 0.1148) in the total study population. However, stratified analyses showed a significant inversed association in the male, those with chronic kidney disease, or those with cancer who quit smoking (all P < 0.05). Cigarette smoking was inversely associated with serum α-Klotho levels among US adults. |
| first_indexed | 2024-03-11T11:05:02Z |
| format | Article |
| id | doaj.art-15f098aeb30c455fb51b02219d0778ee |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T11:05:02Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-15f098aeb30c455fb51b02219d0778ee2023-11-12T12:14:24ZengNature PortfolioScientific Reports2045-23222023-11-011311910.1038/s41598-023-46698-5Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional studyRui Du0Xiaoyan Tang1Meihua Jiang2Shengli Qian3Li Yang4Xiaoling Tong5Wei Huang6Department of Ultrasound, General Hospital of Central Theater CommandDepartment of Cardiology, General Hospital of Central Theater CommandDepartment of Nephrology, General Hospital of Central Theater CommandDepartment of Ultrasound, General Hospital of Central Theater CommandDepartment of Ultrasound, General Hospital of Central Theater CommandDepartment of Out-patient, General Hospital of Central Theater CommandDepartment of Cardiology, General Hospital of Central Theater CommandAbstract Alpha klotho (α-Klotho) is an anti-aging molecule associated with aging and several diseases. Previous studies have reported inconsistent levels of α-Klotho in smokers. This study aimed to demonstrate serum α-Klotho levels in smokers among the US population. This cross-sectional study recruited 11,559 participants (aged 40–79 years; 48.2% males). All data were collected from the 2007–2016 National Health and Nutrition Examination Survey. The study comprised adults with reliable Klotho and smoking questionnaire results. The relationship between smoking and serum α-klotho levels was assessed using multivariate linear regression models after adjusting for potential confounders. We also performed a stratified analysis of clinically important variables. The mean serum α-klotho level among the 11,559 participants was 843.85 pg/mL. After full adjustment, habitual smoking was significantly associated with decreased serum levels of α-klotho level (β = − 34.89; 95% CI − 54.97, − 14.81; P = 0.0013) in the total study population. Furthermore, the stratified analysis indicated that the association was insignificant in the 60–79 age group. Quitting smoking was not significantly associated with serum levels of α-klotho as expected (P = 0.1148) in the total study population. However, stratified analyses showed a significant inversed association in the male, those with chronic kidney disease, or those with cancer who quit smoking (all P < 0.05). Cigarette smoking was inversely associated with serum α-Klotho levels among US adults.https://doi.org/10.1038/s41598-023-46698-5 |
| spellingShingle | Rui Du Xiaoyan Tang Meihua Jiang Shengli Qian Li Yang Xiaoling Tong Wei Huang Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study Scientific Reports |
| title | Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study |
| title_full | Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study |
| title_fullStr | Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study |
| title_full_unstemmed | Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study |
| title_short | Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study |
| title_sort | association between cigarette smoking and serum alpha klotho levels among us adults over 40 years old a cross sectional study |
| url | https://doi.org/10.1038/s41598-023-46698-5 |
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