Metabolic syndrome in children and adolescents with phenylketonuria
OBJECTIVE: This study aimed to identify markers of metabolic syndrome (MS) in patients with phenylketonuria (PKU). METHODS: This was a cross-sectional study consisting of 58 PKU patients (ages of 4-15 years): 29 patients with excess weight, and 29 with normal weight. The biochemical variables assess...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-02-01
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| Series: | Jornal de Pediatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572015000100098&lng=en&tlng=en |
| _version_ | 1818513271089528832 |
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| author | Viviane C. Kanufre Rosângelis D.L. Soares Michelle Rosa A. Alves Marcos J.B. Aguiar Ana Lúcia P. Starling Rocksane C. Norton |
| author_facet | Viviane C. Kanufre Rosângelis D.L. Soares Michelle Rosa A. Alves Marcos J.B. Aguiar Ana Lúcia P. Starling Rocksane C. Norton |
| author_sort | Viviane C. Kanufre |
| collection | DOAJ |
| description | OBJECTIVE: This study aimed to identify markers of metabolic syndrome (MS) in patients with phenylketonuria (PKU). METHODS: This was a cross-sectional study consisting of 58 PKU patients (ages of 4-15 years): 29 patients with excess weight, and 29 with normal weight. The biochemical variables assessed were phenylalanine (phe), total cholesterol, HDL-c, triglycerides, glucose, and basal insulin. The patients had Homeostasis Model Assessment (HOMA) and waist circumference assessed. RESULTS: No inter-group difference was found for phe. Overweight patients had higher levels of triglycerides, basal insulin, and HOMA, but lower concentrations of HDL-cholesterol, when compared to the eutrophic patients. Total cholesterol/HDL-c was significantly higher in the overweight group. A positive correlation between basal insulin level and HOMA with waist circumference was found only in the overweight group. CONCLUSION: The results of this study suggest that patients with PKU and excess weight are potentially vulnerable to the development of metabolic syndrome. Therefore, it is necessary to conduct clinical and laboratory monitoring, aiming to prevent metabolic changes, as well as excessive weight gain and its consequences, particularly cardiovascular risk. |
| first_indexed | 2024-12-10T23:58:53Z |
| format | Article |
| id | doaj.art-15f160d078b94e448640a80c23892ea3 |
| institution | Directory Open Access Journal |
| issn | 1678-4782 |
| language | English |
| last_indexed | 2024-12-10T23:58:53Z |
| publishDate | 2015-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj.art-15f160d078b94e448640a80c23892ea32022-12-22T01:28:31ZengElsevierJornal de Pediatria1678-47822015-02-019119810310.1016/j.jped.2014.06.006S0021-75572015000100098Metabolic syndrome in children and adolescents with phenylketonuriaViviane C. KanufreRosângelis D.L. SoaresMichelle Rosa A. AlvesMarcos J.B. AguiarAna Lúcia P. StarlingRocksane C. NortonOBJECTIVE: This study aimed to identify markers of metabolic syndrome (MS) in patients with phenylketonuria (PKU). METHODS: This was a cross-sectional study consisting of 58 PKU patients (ages of 4-15 years): 29 patients with excess weight, and 29 with normal weight. The biochemical variables assessed were phenylalanine (phe), total cholesterol, HDL-c, triglycerides, glucose, and basal insulin. The patients had Homeostasis Model Assessment (HOMA) and waist circumference assessed. RESULTS: No inter-group difference was found for phe. Overweight patients had higher levels of triglycerides, basal insulin, and HOMA, but lower concentrations of HDL-cholesterol, when compared to the eutrophic patients. Total cholesterol/HDL-c was significantly higher in the overweight group. A positive correlation between basal insulin level and HOMA with waist circumference was found only in the overweight group. CONCLUSION: The results of this study suggest that patients with PKU and excess weight are potentially vulnerable to the development of metabolic syndrome. Therefore, it is necessary to conduct clinical and laboratory monitoring, aiming to prevent metabolic changes, as well as excessive weight gain and its consequences, particularly cardiovascular risk.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572015000100098&lng=en&tlng=enFenilcetonúriaSíndrome metabólicaCrianças e adolescentesExcesso de pesoDieta |
| spellingShingle | Viviane C. Kanufre Rosângelis D.L. Soares Michelle Rosa A. Alves Marcos J.B. Aguiar Ana Lúcia P. Starling Rocksane C. Norton Metabolic syndrome in children and adolescents with phenylketonuria Jornal de Pediatria Fenilcetonúria Síndrome metabólica Crianças e adolescentes Excesso de peso Dieta |
| title | Metabolic syndrome in children and adolescents with phenylketonuria |
| title_full | Metabolic syndrome in children and adolescents with phenylketonuria |
| title_fullStr | Metabolic syndrome in children and adolescents with phenylketonuria |
| title_full_unstemmed | Metabolic syndrome in children and adolescents with phenylketonuria |
| title_short | Metabolic syndrome in children and adolescents with phenylketonuria |
| title_sort | metabolic syndrome in children and adolescents with phenylketonuria |
| topic | Fenilcetonúria Síndrome metabólica Crianças e adolescentes Excesso de peso Dieta |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572015000100098&lng=en&tlng=en |
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