3D heterospecies spheroids of pancreatic stroma and cancer cells demonstrate key phenotypes of pancreatic ductal adenocarcinoma

3D heterospecies spheroids of pancreatic stroma and cancer cells demonstrate key phenotypes of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, partly due to the dense desmoplasia and a lack of suitable model systems to study. In the present work, we developed a 3D heterospecies spheroid model to study the microenvironmental interactions between tumor cells and...

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Bibliographic Details
Main Authors: Xinyuan Liu, Beate Gündel, Xidan Li, Jianping Liu, Anthony Wright, Matthias Löhr, Gustav Arvidsson, Rainer Heuchel
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Translational Oncology
Subjects:
Pancreatic cancer
Cancer associated fibroblasts
Co-culture
Spheroids
Tumor microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321000991

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