The association between organised colorectal cancer screening strategies and reduction of its related mortality: a systematic review and meta-analysis
Abstract Background To assess the long-term association between organised colorectal cancer (CRC) screening strategies and CRC-relate mortality. Methods We systematically reviewed studies on organised CRC screening through PubMed, Ovid Medline, Embase and Cochrane from the inception. We retrieved ch...
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| Format: | Article |
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BMC
2024-03-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-024-12054-7 |
| _version_ | 1797247178287087616 |
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| author | Hanyue Ding Jiaye Lin Zijun Xu Harry H. X. Wang Liwen Huang Junjie Huang Martin C. S. Wong |
| author_facet | Hanyue Ding Jiaye Lin Zijun Xu Harry H. X. Wang Liwen Huang Junjie Huang Martin C. S. Wong |
| author_sort | Hanyue Ding |
| collection | DOAJ |
| description | Abstract Background To assess the long-term association between organised colorectal cancer (CRC) screening strategies and CRC-relate mortality. Methods We systematically reviewed studies on organised CRC screening through PubMed, Ovid Medline, Embase and Cochrane from the inception. We retrieved characteristics of organised CRC screening from included literature and matched mortality (over 50 years) of those areas from the International Agency for Research on Cancer in May 2023. The variations of mortality were reported via the age-standardised mortality ratio. A random-effects model was used to synthesis results. Results We summarised 58 organised CRC screening programmes and recorded > 2.7 million CRC-related deaths from 22 countries where rollout screening programmes were performed. The CRC screening strategy with faecal tests (guaiac faecal occult blood test (gFOBT) or faecal immunochemical tests (FIT)) or colonoscopy as the primary screening offer was associated with a 41.8% reduction in mortality, which was higher than those offered gFOBT (4.4%), FIT (16.7%), gFOBT or FIT (16.2%), and faecal tests (gFOBT or FIT) or flexible sigmoidoscopy (16.7%) as primary screening test. The longer duration of screening was associated with a higher reduction in the pooled age-standardised mortality ratio. In particular, the pooled age-standardised mortality ratio became non-significant when the screening of FIT was implemented for less than 5 years. Conclusions A CRC screening programme running for > 5 years was associated with a reduction of CRC-related mortality. Countries with a heavy burden of CRC should implement sustainable, organised screening providing a choice between faecal tests and colonoscopy as a preferred primary test. |
| first_indexed | 2024-04-24T19:54:34Z |
| format | Article |
| id | doaj.art-15f3b4c154aa4d40910923ab4a2c15cd |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-24T19:54:34Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-15f3b4c154aa4d40910923ab4a2c15cd2024-03-24T12:23:33ZengBMCBMC Cancer1471-24072024-03-012411810.1186/s12885-024-12054-7The association between organised colorectal cancer screening strategies and reduction of its related mortality: a systematic review and meta-analysisHanyue Ding0Jiaye Lin1Zijun Xu2Harry H. X. Wang3Liwen Huang4Junjie Huang5Martin C. S. Wong6JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong KongJC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong KongJC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong KongSchool of Public Health, Sun Yat-Sen UniversityJC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong KongJC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong KongJC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong KongAbstract Background To assess the long-term association between organised colorectal cancer (CRC) screening strategies and CRC-relate mortality. Methods We systematically reviewed studies on organised CRC screening through PubMed, Ovid Medline, Embase and Cochrane from the inception. We retrieved characteristics of organised CRC screening from included literature and matched mortality (over 50 years) of those areas from the International Agency for Research on Cancer in May 2023. The variations of mortality were reported via the age-standardised mortality ratio. A random-effects model was used to synthesis results. Results We summarised 58 organised CRC screening programmes and recorded > 2.7 million CRC-related deaths from 22 countries where rollout screening programmes were performed. The CRC screening strategy with faecal tests (guaiac faecal occult blood test (gFOBT) or faecal immunochemical tests (FIT)) or colonoscopy as the primary screening offer was associated with a 41.8% reduction in mortality, which was higher than those offered gFOBT (4.4%), FIT (16.7%), gFOBT or FIT (16.2%), and faecal tests (gFOBT or FIT) or flexible sigmoidoscopy (16.7%) as primary screening test. The longer duration of screening was associated with a higher reduction in the pooled age-standardised mortality ratio. In particular, the pooled age-standardised mortality ratio became non-significant when the screening of FIT was implemented for less than 5 years. Conclusions A CRC screening programme running for > 5 years was associated with a reduction of CRC-related mortality. Countries with a heavy burden of CRC should implement sustainable, organised screening providing a choice between faecal tests and colonoscopy as a preferred primary test.https://doi.org/10.1186/s12885-024-12054-7Colorectal neoplasmSecondary preventionEarly detection of cancerMortality |
| spellingShingle | Hanyue Ding Jiaye Lin Zijun Xu Harry H. X. Wang Liwen Huang Junjie Huang Martin C. S. Wong The association between organised colorectal cancer screening strategies and reduction of its related mortality: a systematic review and meta-analysis BMC Cancer Colorectal neoplasm Secondary prevention Early detection of cancer Mortality |
| title | The association between organised colorectal cancer screening strategies and reduction of its related mortality: a systematic review and meta-analysis |
| title_full | The association between organised colorectal cancer screening strategies and reduction of its related mortality: a systematic review and meta-analysis |
| title_fullStr | The association between organised colorectal cancer screening strategies and reduction of its related mortality: a systematic review and meta-analysis |
| title_full_unstemmed | The association between organised colorectal cancer screening strategies and reduction of its related mortality: a systematic review and meta-analysis |
| title_short | The association between organised colorectal cancer screening strategies and reduction of its related mortality: a systematic review and meta-analysis |
| title_sort | association between organised colorectal cancer screening strategies and reduction of its related mortality a systematic review and meta analysis |
| topic | Colorectal neoplasm Secondary prevention Early detection of cancer Mortality |
| url | https://doi.org/10.1186/s12885-024-12054-7 |
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