Arterial stiffness and its associations with left ventricular diastolic function according to heart failure types
Abstract Background Little is known about the characteristics of arterial stiffness in heart failure (HF). This study was performed to compare the degree of arterial stiffness and its association with left ventricular (LV) diastolic function among three groups: control subjects, patients with HF wit...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-03-01
|
| Series: | Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40885-022-00233-2 |
| _version_ | 1827984003838246912 |
|---|---|
| author | Hack-Lyoung Kim Jaehoon Chung Seokmoon Han Hyun Sung Joh Woo-Hyun Lim Jae-Bin Seo Sang-Hyun Kim Joo-Hee Zo Myung-A Kim |
| author_facet | Hack-Lyoung Kim Jaehoon Chung Seokmoon Han Hyun Sung Joh Woo-Hyun Lim Jae-Bin Seo Sang-Hyun Kim Joo-Hee Zo Myung-A Kim |
| author_sort | Hack-Lyoung Kim |
| collection | DOAJ |
| description | Abstract Background Little is known about the characteristics of arterial stiffness in heart failure (HF). This study was performed to compare the degree of arterial stiffness and its association with left ventricular (LV) diastolic function among three groups: control subjects, patients with HF with reduced ejection fraction (HFrEF), and patients with HF with preserved ejection fraction (HFpEF). Methods A total of 83 patients with HFrEF, 68 patients with HFpEF, and 84 control subjects were analyzed. All HF patients had a history of hospitalization for HF treatment. Brachial-ankle pulse wave velocity (baPWV) measurement and transthoracic echocardiography were performed at the same day in a stable condition. Results The baPWV was significantly higher in patients with both HFrEF and HFpEF compared to control subjects (1,661 ± 390, 1,909 ± 466, and 1,477 ± 296 cm/sec, respectively; P < 0.05 for each). After adjustment of age, baPWV values were similar between patients with HFrEF and HFpEF (P = 0.948). In the multiple linear regression analysis, baPWV was significantly associated with both septal e′ velocity (β = –0.360, P = 0.001) and E/e′ (β = 0.344, P = 0.001). However, baPWV was not associated with either of the diastolic indices in HFrEF group. The baPWV was associated only with septal e′ velocity (β = –0.429, P = 0.002) but not with E/e′ in the HFpEF group in the same multivariable analysis. Conclusions Although arterial stiffness was increased, its association with LV diastolic function was attenuated in HF patients compared to control subjects. The degree of arterial stiffening was similar between HFrEF and HFpEF. |
| first_indexed | 2024-04-09T22:54:37Z |
| format | Article |
| id | doaj.art-15f508a2c6a344e7bc4aa869b591d1ce |
| institution | Directory Open Access Journal |
| issn | 2056-5909 |
| language | English |
| last_indexed | 2024-04-09T22:54:37Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Hypertension |
| spelling | doaj.art-15f508a2c6a344e7bc4aa869b591d1ce2023-03-22T11:20:00ZengBMCClinical Hypertension2056-59092023-03-012911910.1186/s40885-022-00233-2Arterial stiffness and its associations with left ventricular diastolic function according to heart failure typesHack-Lyoung Kim0Jaehoon Chung1Seokmoon Han2Hyun Sung Joh3Woo-Hyun Lim4Jae-Bin Seo5Sang-Hyun Kim6Joo-Hee Zo7Myung-A Kim8Division of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of MedicineDivision of Cardiology, Department of Internal Medicine, National Medical CenterDepartment of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical CenterDivision of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of MedicineDivision of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of MedicineDivision of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of MedicineDivision of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of MedicineDivision of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of MedicineDivision of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of MedicineAbstract Background Little is known about the characteristics of arterial stiffness in heart failure (HF). This study was performed to compare the degree of arterial stiffness and its association with left ventricular (LV) diastolic function among three groups: control subjects, patients with HF with reduced ejection fraction (HFrEF), and patients with HF with preserved ejection fraction (HFpEF). Methods A total of 83 patients with HFrEF, 68 patients with HFpEF, and 84 control subjects were analyzed. All HF patients had a history of hospitalization for HF treatment. Brachial-ankle pulse wave velocity (baPWV) measurement and transthoracic echocardiography were performed at the same day in a stable condition. Results The baPWV was significantly higher in patients with both HFrEF and HFpEF compared to control subjects (1,661 ± 390, 1,909 ± 466, and 1,477 ± 296 cm/sec, respectively; P < 0.05 for each). After adjustment of age, baPWV values were similar between patients with HFrEF and HFpEF (P = 0.948). In the multiple linear regression analysis, baPWV was significantly associated with both septal e′ velocity (β = –0.360, P = 0.001) and E/e′ (β = 0.344, P = 0.001). However, baPWV was not associated with either of the diastolic indices in HFrEF group. The baPWV was associated only with septal e′ velocity (β = –0.429, P = 0.002) but not with E/e′ in the HFpEF group in the same multivariable analysis. Conclusions Although arterial stiffness was increased, its association with LV diastolic function was attenuated in HF patients compared to control subjects. The degree of arterial stiffening was similar between HFrEF and HFpEF.https://doi.org/10.1186/s40885-022-00233-2Vascular stiffnessDiastolic functionHeart failurePulse wave analysis |
| spellingShingle | Hack-Lyoung Kim Jaehoon Chung Seokmoon Han Hyun Sung Joh Woo-Hyun Lim Jae-Bin Seo Sang-Hyun Kim Joo-Hee Zo Myung-A Kim Arterial stiffness and its associations with left ventricular diastolic function according to heart failure types Clinical Hypertension Vascular stiffness Diastolic function Heart failure Pulse wave analysis |
| title | Arterial stiffness and its associations with left ventricular diastolic function according to heart failure types |
| title_full | Arterial stiffness and its associations with left ventricular diastolic function according to heart failure types |
| title_fullStr | Arterial stiffness and its associations with left ventricular diastolic function according to heart failure types |
| title_full_unstemmed | Arterial stiffness and its associations with left ventricular diastolic function according to heart failure types |
| title_short | Arterial stiffness and its associations with left ventricular diastolic function according to heart failure types |
| title_sort | arterial stiffness and its associations with left ventricular diastolic function according to heart failure types |
| topic | Vascular stiffness Diastolic function Heart failure Pulse wave analysis |
| url | https://doi.org/10.1186/s40885-022-00233-2 |
| work_keys_str_mv | AT hacklyoungkim arterialstiffnessanditsassociationswithleftventriculardiastolicfunctionaccordingtoheartfailuretypes AT jaehoonchung arterialstiffnessanditsassociationswithleftventriculardiastolicfunctionaccordingtoheartfailuretypes AT seokmoonhan arterialstiffnessanditsassociationswithleftventriculardiastolicfunctionaccordingtoheartfailuretypes AT hyunsungjoh arterialstiffnessanditsassociationswithleftventriculardiastolicfunctionaccordingtoheartfailuretypes AT woohyunlim arterialstiffnessanditsassociationswithleftventriculardiastolicfunctionaccordingtoheartfailuretypes AT jaebinseo arterialstiffnessanditsassociationswithleftventriculardiastolicfunctionaccordingtoheartfailuretypes AT sanghyunkim arterialstiffnessanditsassociationswithleftventriculardiastolicfunctionaccordingtoheartfailuretypes AT jooheezo arterialstiffnessanditsassociationswithleftventriculardiastolicfunctionaccordingtoheartfailuretypes AT myungakim arterialstiffnessanditsassociationswithleftventriculardiastolicfunctionaccordingtoheartfailuretypes |