Chimeric Vaccines Designed by Immunoinformatics-Activated Polyfunctional and Memory T Cells That Trigger Protection against Experimental Visceral Leishmaniasis

Chimeric Vaccines Designed by Immunoinformatics-Activated Polyfunctional and Memory T Cells That Trigger Protection against Experimental Visceral Leishmaniasis

Many vaccine candidates against visceral leishmaniasis (VL) have been proposed; however, to date, none of them have been efficacious for the human or canine disease. On this basis, the design of leishmaniasis vaccines has been constantly changing, and the use of approaches to select specific epitope...

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Bibliographic Details
Main Authors: Rory Cristiane Fortes De Brito, Jeronimo Conceição Ruiz, Jamille Mirelle de Oliveira Cardoso, Thais Lopes Valentim Di Paschoale Ostolin, Levi Eduardo Soares Reis, Fernando Augusto Siqueira Mathias, Rodrigo Dian de Oliveira Aguiar-Soares, Bruno Mendes Roatt, Rodrigo Corrêa-Oliveira, Daniela de Melo Resende, Alexandre Barbosa Reis
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Vaccines
Subjects:
reverse vaccinology
immunoinformatics
chimera vaccine
Leishmania infantum
polyfunctional T cells
memory T cells
Online Access:https://www.mdpi.com/2076-393X/8/2/252

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