Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a randomized clinical trial
ABSTRACT Objective: To evaluate the effect of curcumin supplementation on the body compositions and biochemical parameters of Brazilian women with high waist circumferences. Materials and methods: This is a blind, randomized, placebo-controlled clinical trial conducted in 2016 with 35 Brazilian wo...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2022-10-01
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| Series: | Archives of Endocrinology and Metabolism |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005010201&lng=en&tlng=en |
| _version_ | 1811181375890391040 |
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| author | Pamela Cristina de Sousa Guardiano Reis Ana Gabriella Pereira Alves Lídia Andreu Guillo Menandes Alves de Sousa Neto Neidiane Rosa Trindade Maria Sebastiana Silva |
| author_facet | Pamela Cristina de Sousa Guardiano Reis Ana Gabriella Pereira Alves Lídia Andreu Guillo Menandes Alves de Sousa Neto Neidiane Rosa Trindade Maria Sebastiana Silva |
| author_sort | Pamela Cristina de Sousa Guardiano Reis |
| collection | DOAJ |
| description | ABSTRACT Objective: To evaluate the effect of curcumin supplementation on the body compositions and biochemical parameters of Brazilian women with high waist circumferences. Materials and methods: This is a blind, randomized, placebo-controlled clinical trial conducted in 2016 with 35 Brazilian women with high waist circumference (WC). In total, 80 participants were randomized [38 in the placebo group (PG) and 42 in the supplemented group (SG)], but at the end of the protocol, 20 individuals in the PG and 15 in the SG were evaluated. The sample consumed one capsule of curcumin (500 mg/day) (Curcumin C3 Complex®) or a placebo for 90 days. Body weight, height, body mass index, WC, body fat, fat free mass, fasting glucose (FG), lipid profile [triglycerides (TGs), total cholesterol (TC), HDL-c and LDL-c], physical activity level and food intake (energy, carbohydrate, total fat and protein) data were evaluated before and after the intervention. Results: Curcumin supplementation reduced body mass (p < 0.040) but did not alter other anthropometric parameters or body composition (p ≥ 0.050). In relation to the biochemical profile, the SG saw reductions in FG (p < 0.001), TGs (p < 0.001) and TC (p = 0.001) compared with the PG. At the baseline and during the intervention, the practice of physical activity and food intake did not differ between the SG and PG (p ≥ 0.050). Conclusion: Curcumin supplementation improved the blood glucose and lipid profile of Brazilian women with high WC, without altering body composition. New studies with larger sample sizes and longer durations are important for identifying more robust data regarding the proposal of this work. |
| first_indexed | 2024-04-11T09:15:39Z |
| format | Article |
| id | doaj.art-15f930e4eb9949ccb966017704dfe3e3 |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-04-11T09:15:39Z |
| publishDate | 2022-10-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-15f930e4eb9949ccb966017704dfe3e32022-12-22T04:32:20ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922022-10-0110.20945/2359-3997000000513Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a randomized clinical trialPamela Cristina de Sousa Guardiano Reishttps://orcid.org/0000-0003-4462-7211Ana Gabriella Pereira Alveshttps://orcid.org/0000-0002-0933-1653Lídia Andreu Guillohttps://orcid.org/0000-0003-3220-6890Menandes Alves de Sousa Netohttps://orcid.org/0000-0001-5560-6884Neidiane Rosa Trindadehttps://orcid.org/0000-0003-2649-868XMaria Sebastiana Silvahttps://orcid.org/0000-0001-7265-5872ABSTRACT Objective: To evaluate the effect of curcumin supplementation on the body compositions and biochemical parameters of Brazilian women with high waist circumferences. Materials and methods: This is a blind, randomized, placebo-controlled clinical trial conducted in 2016 with 35 Brazilian women with high waist circumference (WC). In total, 80 participants were randomized [38 in the placebo group (PG) and 42 in the supplemented group (SG)], but at the end of the protocol, 20 individuals in the PG and 15 in the SG were evaluated. The sample consumed one capsule of curcumin (500 mg/day) (Curcumin C3 Complex®) or a placebo for 90 days. Body weight, height, body mass index, WC, body fat, fat free mass, fasting glucose (FG), lipid profile [triglycerides (TGs), total cholesterol (TC), HDL-c and LDL-c], physical activity level and food intake (energy, carbohydrate, total fat and protein) data were evaluated before and after the intervention. Results: Curcumin supplementation reduced body mass (p < 0.040) but did not alter other anthropometric parameters or body composition (p ≥ 0.050). In relation to the biochemical profile, the SG saw reductions in FG (p < 0.001), TGs (p < 0.001) and TC (p = 0.001) compared with the PG. At the baseline and during the intervention, the practice of physical activity and food intake did not differ between the SG and PG (p ≥ 0.050). Conclusion: Curcumin supplementation improved the blood glucose and lipid profile of Brazilian women with high WC, without altering body composition. New studies with larger sample sizes and longer durations are important for identifying more robust data regarding the proposal of this work.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005010201&lng=en&tlng=enCurcuminwomenblood glucosecholesteroltriglycerides |
| spellingShingle | Pamela Cristina de Sousa Guardiano Reis Ana Gabriella Pereira Alves Lídia Andreu Guillo Menandes Alves de Sousa Neto Neidiane Rosa Trindade Maria Sebastiana Silva Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a randomized clinical trial Archives of Endocrinology and Metabolism Curcumin women blood glucose cholesterol triglycerides |
| title | Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a randomized clinical trial |
| title_full | Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a randomized clinical trial |
| title_fullStr | Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a randomized clinical trial |
| title_full_unstemmed | Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a randomized clinical trial |
| title_short | Curcumin supplementation reduces blood glucose and serum lipids of Brazilian women with high waist circumference: a randomized clinical trial |
| title_sort | curcumin supplementation reduces blood glucose and serum lipids of brazilian women with high waist circumference a randomized clinical trial |
| topic | Curcumin women blood glucose cholesterol triglycerides |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972022005010201&lng=en&tlng=en |
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