Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action

Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action

Abstract Background Malaria remains one of the most virulent and deadliest parasitic disease in the world, particularly in Africa and Southeast Asia. Widespread occurrence of artemisinin-resistant Plasmodium falciparum strains from the Greater Mekong Subregion is alarming. This hinders the national...

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Bibliographic Details
Main Authors: Jing Wei Lai, Mohd Jamil Maah, Kong Wai Tan, Rozie Sarip, Yvonne Ai Lian Lim, Rakesh Ganguly, Loke Tim Khaw, Chew Hee Ng
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Malaria Journal
Subjects:
Copper complex
Zinc complex
Antimalarial
Plasmodium falciparum
Reactive oxygen species
Depolarization of mitochondrial membrane potential
Online Access:https://doi.org/10.1186/s12936-022-04406-0

Internet

https://doi.org/10.1186/s12936-022-04406-0

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