HSC-independent definitive hematopoiesis persists into adult life
Summary: It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells (HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to primitive erythro-myeloid cells and tissue-resident innate immune cells arising in the embryo. Here, surprising...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
|
| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723002504 |
| _version_ | 1811154377479553024 |
|---|---|
| author | Michihiro Kobayashi Haichao Wei Takashi Yamanashi Nathalia Azevedo Portilho Samuel Cornelius Noemi Valiente Chika Nishida Haizi Cheng Augusto Latorre W. Jim Zheng Joonsoo Kang Jun Seita David J. Shih Jia Qian Wu Momoko Yoshimoto |
| author_facet | Michihiro Kobayashi Haichao Wei Takashi Yamanashi Nathalia Azevedo Portilho Samuel Cornelius Noemi Valiente Chika Nishida Haizi Cheng Augusto Latorre W. Jim Zheng Joonsoo Kang Jun Seita David J. Shih Jia Qian Wu Momoko Yoshimoto |
| author_sort | Michihiro Kobayashi |
| collection | DOAJ |
| description | Summary: It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells (HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to primitive erythro-myeloid cells and tissue-resident innate immune cells arising in the embryo. Here, surprisingly, we find that significant percentages of lymphocytes are not derived from HSCs, even in 1-year-old mice. Instead, multiple waves of hematopoiesis occur from embryonic day 7.5 (E7.5) to E11.5 endothelial cells, which simultaneously produce HSCs and lymphoid progenitors that constitute many layers of adaptive T and B lymphocytes in adult mice. Additionally, HSC lineage tracing reveals that the contribution of fetal liver HSCs to peritoneal B-1a cells is minimal and that the majority of B-1a cells are HSC independent. Our discovery of extensive HSC-independent lymphocytes in adult mice attests to the complex blood developmental dynamics spanning the embryo-to-adult transition and challenges the paradigm of HSCs exclusively underpinning the postnatal immune system. |
| first_indexed | 2024-04-10T04:14:33Z |
| format | Article |
| id | doaj.art-15fae9bc6d5246788df778501042a113 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-10T04:14:33Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-15fae9bc6d5246788df778501042a1132023-03-12T04:20:57ZengElsevierCell Reports2211-12472023-03-01423112239HSC-independent definitive hematopoiesis persists into adult lifeMichihiro Kobayashi0Haichao Wei1Takashi Yamanashi2Nathalia Azevedo Portilho3Samuel Cornelius4Noemi Valiente5Chika Nishida6Haizi Cheng7Augusto Latorre8W. Jim Zheng9Joonsoo Kang10Jun Seita11David J. Shih12Jia Qian Wu13Momoko Yoshimoto14Center for Stem Cell and Regenerative Medicine, Brown Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USACenter for Stem Cell and Regenerative Medicine, Brown Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USAAdvanced Data Science Project, RIKEN Information R&D and Strategy Headquarters, Tokyo 103-0027, Japan; Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa 230-0045, JapanCenter for Stem Cell and Regenerative Medicine, Brown Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USACenter for Stem Cell and Regenerative Medicine, Brown Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USACenter for Stem Cell and Regenerative Medicine, Brown Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USACenter for Stem Cell and Regenerative Medicine, Brown Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USACenter for Stem Cell and Regenerative Medicine, Brown Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USACenter for Stem Cell and Regenerative Medicine, Brown Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USASchool of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USADepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USAAdvanced Data Science Project, RIKEN Information R&D and Strategy Headquarters, Tokyo 103-0027, Japan; Center for Integrative Medical Sciences, RIKEN, Yokohama, Kanagawa 230-0045, JapanSchool of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, ChinaCenter for Stem Cell and Regenerative Medicine, Brown Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The Vivian L. Smith Department of Neurosurgery, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USACenter for Stem Cell and Regenerative Medicine, Brown Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Corresponding authorSummary: It is widely believed that hematopoiesis after birth is established by hematopoietic stem cells (HSCs) in the bone marrow and that HSC-independent hematopoiesis is limited only to primitive erythro-myeloid cells and tissue-resident innate immune cells arising in the embryo. Here, surprisingly, we find that significant percentages of lymphocytes are not derived from HSCs, even in 1-year-old mice. Instead, multiple waves of hematopoiesis occur from embryonic day 7.5 (E7.5) to E11.5 endothelial cells, which simultaneously produce HSCs and lymphoid progenitors that constitute many layers of adaptive T and B lymphocytes in adult mice. Additionally, HSC lineage tracing reveals that the contribution of fetal liver HSCs to peritoneal B-1a cells is minimal and that the majority of B-1a cells are HSC independent. Our discovery of extensive HSC-independent lymphocytes in adult mice attests to the complex blood developmental dynamics spanning the embryo-to-adult transition and challenges the paradigm of HSCs exclusively underpinning the postnatal immune system.http://www.sciencedirect.com/science/article/pii/S2211124723002504CP: Developmental biology |
| spellingShingle | Michihiro Kobayashi Haichao Wei Takashi Yamanashi Nathalia Azevedo Portilho Samuel Cornelius Noemi Valiente Chika Nishida Haizi Cheng Augusto Latorre W. Jim Zheng Joonsoo Kang Jun Seita David J. Shih Jia Qian Wu Momoko Yoshimoto HSC-independent definitive hematopoiesis persists into adult life Cell Reports CP: Developmental biology |
| title | HSC-independent definitive hematopoiesis persists into adult life |
| title_full | HSC-independent definitive hematopoiesis persists into adult life |
| title_fullStr | HSC-independent definitive hematopoiesis persists into adult life |
| title_full_unstemmed | HSC-independent definitive hematopoiesis persists into adult life |
| title_short | HSC-independent definitive hematopoiesis persists into adult life |
| title_sort | hsc independent definitive hematopoiesis persists into adult life |
| topic | CP: Developmental biology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723002504 |
| work_keys_str_mv | AT michihirokobayashi hscindependentdefinitivehematopoiesispersistsintoadultlife AT haichaowei hscindependentdefinitivehematopoiesispersistsintoadultlife AT takashiyamanashi hscindependentdefinitivehematopoiesispersistsintoadultlife AT nathaliaazevedoportilho hscindependentdefinitivehematopoiesispersistsintoadultlife AT samuelcornelius hscindependentdefinitivehematopoiesispersistsintoadultlife AT noemivaliente hscindependentdefinitivehematopoiesispersistsintoadultlife AT chikanishida hscindependentdefinitivehematopoiesispersistsintoadultlife AT haizicheng hscindependentdefinitivehematopoiesispersistsintoadultlife AT augustolatorre hscindependentdefinitivehematopoiesispersistsintoadultlife AT wjimzheng hscindependentdefinitivehematopoiesispersistsintoadultlife AT joonsookang hscindependentdefinitivehematopoiesispersistsintoadultlife AT junseita hscindependentdefinitivehematopoiesispersistsintoadultlife AT davidjshih hscindependentdefinitivehematopoiesispersistsintoadultlife AT jiaqianwu hscindependentdefinitivehematopoiesispersistsintoadultlife AT momokoyoshimoto hscindependentdefinitivehematopoiesispersistsintoadultlife |