Focus on the role of substance P in chronic urticaria
Abstract Background Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized. Methods Literature data regarding the possible role of SP in chronic urticaria/chronic s...
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | Clinical and Molecular Allergy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12948-018-0101-z |
| _version_ | 1811204650668392448 |
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| author | Gino A. Vena Nicoletta Cassano E. Di Leo G. F. Calogiuri Eustachio Nettis |
| author_facet | Gino A. Vena Nicoletta Cassano E. Di Leo G. F. Calogiuri Eustachio Nettis |
| author_sort | Gino A. Vena |
| collection | DOAJ |
| description | Abstract Background Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized. Methods Literature data regarding the possible role of SP in chronic urticaria/chronic spontaneous urticaria (CSU) have been reviewed and summarized in this manuscript. This review is based on pertinent articles that were retrieved by a selective literature search in the PubMed database. Articles in English published up to July 2018 were taken into consideration. Results Recent studies in patients with CSU have demonstrated that circulating levels of SP are significantly elevated, in correlation with disease severity, and that SP-positive basophils are upregulated. SP has been shown to trigger degranulation in basophils derived from CSU patients. Moreover, SP can be involved in pseudoallergic reactions and may act as a histamine-releasing factor in a subset of patients with CSU. Current evidence suggests that the biological activity of SP can be exerted not only through the conventional NK-1 receptor but also through the recently identified Mas-related G protein-coupled receptors. MRGPRX2 can cause mast cell activation and has been found to be upregulated in the skin of patients with severe chronic urticaria. Conclusions Many findings seem to support the pathogenic involvement of SP in chronic urticaria/CSU. However, further studies are necessary to elucidate the role of SP as a mediator in CSU pathogenesis and a potential new therapeutic target. |
| first_indexed | 2024-04-12T03:16:09Z |
| format | Article |
| id | doaj.art-15fb75a692c34788a0309d5caeefef58 |
| institution | Directory Open Access Journal |
| issn | 1476-7961 |
| language | English |
| last_indexed | 2024-04-12T03:16:09Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical and Molecular Allergy |
| spelling | doaj.art-15fb75a692c34788a0309d5caeefef582022-12-22T03:50:04ZengBMCClinical and Molecular Allergy1476-79612018-11-011611610.1186/s12948-018-0101-zFocus on the role of substance P in chronic urticariaGino A. Vena0Nicoletta Cassano1E. Di Leo2G. F. Calogiuri3Eustachio Nettis4Dermatology and Venereology Private PracticeDermatology and Venereology Private PracticeSection of Allergy and Clinical Immunology, Unit of Internal Medicine, “F. Miulli” HospitalPneumology Department, Sacro Cuore HospitalDepartment of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari-Aldo MoroAbstract Background Emerging data have strengthened the importance of substance P (SP) as a proinflammatory mediator in human pathology. A role for SP in the pathogenesis of urticaria has long been hypothesized. Methods Literature data regarding the possible role of SP in chronic urticaria/chronic spontaneous urticaria (CSU) have been reviewed and summarized in this manuscript. This review is based on pertinent articles that were retrieved by a selective literature search in the PubMed database. Articles in English published up to July 2018 were taken into consideration. Results Recent studies in patients with CSU have demonstrated that circulating levels of SP are significantly elevated, in correlation with disease severity, and that SP-positive basophils are upregulated. SP has been shown to trigger degranulation in basophils derived from CSU patients. Moreover, SP can be involved in pseudoallergic reactions and may act as a histamine-releasing factor in a subset of patients with CSU. Current evidence suggests that the biological activity of SP can be exerted not only through the conventional NK-1 receptor but also through the recently identified Mas-related G protein-coupled receptors. MRGPRX2 can cause mast cell activation and has been found to be upregulated in the skin of patients with severe chronic urticaria. Conclusions Many findings seem to support the pathogenic involvement of SP in chronic urticaria/CSU. However, further studies are necessary to elucidate the role of SP as a mediator in CSU pathogenesis and a potential new therapeutic target.http://link.springer.com/article/10.1186/s12948-018-0101-zSubstance PChronic urticariaChronic spontaneous urticariaNeuropeptidesMast cellsBasophils |
| spellingShingle | Gino A. Vena Nicoletta Cassano E. Di Leo G. F. Calogiuri Eustachio Nettis Focus on the role of substance P in chronic urticaria Clinical and Molecular Allergy Substance P Chronic urticaria Chronic spontaneous urticaria Neuropeptides Mast cells Basophils |
| title | Focus on the role of substance P in chronic urticaria |
| title_full | Focus on the role of substance P in chronic urticaria |
| title_fullStr | Focus on the role of substance P in chronic urticaria |
| title_full_unstemmed | Focus on the role of substance P in chronic urticaria |
| title_short | Focus on the role of substance P in chronic urticaria |
| title_sort | focus on the role of substance p in chronic urticaria |
| topic | Substance P Chronic urticaria Chronic spontaneous urticaria Neuropeptides Mast cells Basophils |
| url | http://link.springer.com/article/10.1186/s12948-018-0101-z |
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