A nationwide survey of non-IgE-mediated gastrointestinal food allergies in neonates and infants
Background: Non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFAs) seem to be increasing rapidly worldwide. However, nationwide studies have been limited to food-protein-induced enterocolitis (FPIES) and food-protein-induced allergic proctocolitis (FPIAP), with little attention to other no...
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Elsevier
2024-04-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893023001077 |
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| author | Hiroko Suzuki Naho Morisaki Saori Nagashima Tamotsu Matsunaga Shoko Matsushita Akira Iino Yuichiro Tanaka Hisashi Nishimori Shun Munakata Manabu Kemmochi Yoshitaka Murakami Miori Sato Kenji Toyokuni Kiwako Yamamoto-Hanada Hideaki Morita Tatsuki Fukuie Yoshiyuki Yamada Yoshikazu Ohtsuka Katsuhiro Arai Yukihiro Ohya Hirohisa Saito Kenji Matsumoto Ichiro Nomura |
| author_facet | Hiroko Suzuki Naho Morisaki Saori Nagashima Tamotsu Matsunaga Shoko Matsushita Akira Iino Yuichiro Tanaka Hisashi Nishimori Shun Munakata Manabu Kemmochi Yoshitaka Murakami Miori Sato Kenji Toyokuni Kiwako Yamamoto-Hanada Hideaki Morita Tatsuki Fukuie Yoshiyuki Yamada Yoshikazu Ohtsuka Katsuhiro Arai Yukihiro Ohya Hirohisa Saito Kenji Matsumoto Ichiro Nomura |
| author_sort | Hiroko Suzuki |
| collection | DOAJ |
| description | Background: Non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFAs) seem to be increasing rapidly worldwide. However, nationwide studies have been limited to food-protein-induced enterocolitis (FPIES) and food-protein-induced allergic proctocolitis (FPIAP), with little attention to other non-IgE-GIFA subgroups. The aim of this study was to elucidate the clinical features of all patients with non-IgE-GIFAs, not just certain subgroups. Methods: We conducted a nationwide cross-sectional survey of non-IgE-GIFAs in Japan from April 2015 through March 2016. A questionnaire was sent to hospitals and clinics throughout Japan. The questionnaire asked about the number of physician-diagnosed non-IgE-GIFA patients, the status of fulfillment of the diagnostic criteria, tentative classification into 4 clusters based on the initial symptoms, the day of onset after birth, complications, and the suspected offending food(s). Results: The response rate to that questionnaire was 67.6% from hospitals and 47.4% from clinics. Analyses were conducted about “diagnosis-probable” patient cohort (n = 402) and the “diagnosis-confirmed” patients (n = 80). In half of the reported non-IgE-GIFA patients, onset occurred in the neonatal period. The patients were evenly distributed among 4 non-IgE-GIFA clusters. In Cluster 1, with symptoms of vomiting and bloody stool, the onset showed a median of 7 days after birth, which was the earliest among the clusters. Cow's milk was the most common causative food. Conclusions: In half of the patients, the onset of non-IgE-GIFAs was in the neonatal period. This highlights the importance of studying the pathogenesis in the fetal and neonatal periods. |
| first_indexed | 2024-04-24T17:28:53Z |
| format | Article |
| id | doaj.art-15fb9249a96a4d5ca922505ea4cd0f1c |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-04-24T17:28:53Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-15fb9249a96a4d5ca922505ea4cd0f1c2024-03-28T06:37:15ZengElsevierAllergology International1323-89302024-04-01732264274A nationwide survey of non-IgE-mediated gastrointestinal food allergies in neonates and infantsHiroko Suzuki0Naho Morisaki1Saori Nagashima2Tamotsu Matsunaga3Shoko Matsushita4Akira Iino5Yuichiro Tanaka6Hisashi Nishimori7Shun Munakata8Manabu Kemmochi9Yoshitaka Murakami10Miori Sato11Kenji Toyokuni12Kiwako Yamamoto-Hanada13Hideaki Morita14Tatsuki Fukuie15Yoshiyuki Yamada16Yoshikazu Ohtsuka17Katsuhiro Arai18Yukihiro Ohya19Hirohisa Saito20Kenji Matsumoto21Ichiro Nomura22National Research Institute for Child Health and Development, Division of Eosinophilic Gastrointestinal Disorders, Tokyo, Japan; Todachuo General Hospital, Department of Pediatrics, Saitama, JapanNational Center for Child Health and Development, Department of Social Medicine, Tokyo, JapanNational Research Institute for Child Health and Development, Division of Eosinophilic Gastrointestinal Disorders, Tokyo, JapanTodachuo General Hospital, Department of Pediatrics, Saitama, JapanTokyo Metropolitan Children's Medical Center, Department of Allergy, Tokyo, JapanTokyo Metropolitan Children's Medical Center, Department of Allergy, Tokyo, JapanNational Center for Child Health and Development, Department of General Pediatrics and Interdisciplinary Medicine, Tokyo, JapanMie Prefectural General Medical Center, Department of Pediatrics, Mie, JapanNagano Children's Hospital, Department of Neonatology, Nagano, JapanKitasato University Hospital, Department of Pediatrics, Kanagawa, JapanEhime Prefectural Imabari Hospital, Department of Pediatrics, Ehime, JapanNational Center for Child Health and Development, Allergy Center, Tokyo, JapanNational Center for Child Health and Development, Allergy Center, Tokyo, JapanNational Center for Child Health and Development, Allergy Center, Tokyo, JapanNational Research Institute for Child Health and Development, Department of Allergy and Clinical Immunology, Tokyo, JapanNational Center for Child Health and Development, Allergy Center, Tokyo, JapanTokai University School of Medicine, Department of Pediatrics, Kanagawa, JapanJuntendo University School of Medicine, Department of Pediatrics and Adolescent Medicine, Tokyo, JapanNational Center for Child Health and Development, Allergy Center, Tokyo, Japan; National Center for Child Health and Development, Division of Gastroenterology, Tokyo, JapanNational Center for Child Health and Development, Allergy Center, Tokyo, JapanNational Research Institute for Child Health and Development, Department of Allergy and Clinical Immunology, Tokyo, JapanNational Research Institute for Child Health and Development, Department of Allergy and Clinical Immunology, Tokyo, JapanNational Research Institute for Child Health and Development, Division of Eosinophilic Gastrointestinal Disorders, Tokyo, Japan; National Center for Child Health and Development, Allergy Center, Tokyo, Japan; Corresponding author. Division of Eosinophilic Gastrointestinal Disorders, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, JapanBackground: Non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFAs) seem to be increasing rapidly worldwide. However, nationwide studies have been limited to food-protein-induced enterocolitis (FPIES) and food-protein-induced allergic proctocolitis (FPIAP), with little attention to other non-IgE-GIFA subgroups. The aim of this study was to elucidate the clinical features of all patients with non-IgE-GIFAs, not just certain subgroups. Methods: We conducted a nationwide cross-sectional survey of non-IgE-GIFAs in Japan from April 2015 through March 2016. A questionnaire was sent to hospitals and clinics throughout Japan. The questionnaire asked about the number of physician-diagnosed non-IgE-GIFA patients, the status of fulfillment of the diagnostic criteria, tentative classification into 4 clusters based on the initial symptoms, the day of onset after birth, complications, and the suspected offending food(s). Results: The response rate to that questionnaire was 67.6% from hospitals and 47.4% from clinics. Analyses were conducted about “diagnosis-probable” patient cohort (n = 402) and the “diagnosis-confirmed” patients (n = 80). In half of the reported non-IgE-GIFA patients, onset occurred in the neonatal period. The patients were evenly distributed among 4 non-IgE-GIFA clusters. In Cluster 1, with symptoms of vomiting and bloody stool, the onset showed a median of 7 days after birth, which was the earliest among the clusters. Cow's milk was the most common causative food. Conclusions: In half of the patients, the onset of non-IgE-GIFAs was in the neonatal period. This highlights the importance of studying the pathogenesis in the fetal and neonatal periods.http://www.sciencedirect.com/science/article/pii/S1323893023001077Eosinophilic gastrointestinal disorder (EGID)Food-protein-induced allergic proctocolitis (FPIAP)Food-protein-induced enterocolitis (FPIES)Food-protein-induced enteropathy (FPE)Non-IgE-mediated gastrointestinal food allergy (non-IgE-GIFA, non-IgE-GIFAs) |
| spellingShingle | Hiroko Suzuki Naho Morisaki Saori Nagashima Tamotsu Matsunaga Shoko Matsushita Akira Iino Yuichiro Tanaka Hisashi Nishimori Shun Munakata Manabu Kemmochi Yoshitaka Murakami Miori Sato Kenji Toyokuni Kiwako Yamamoto-Hanada Hideaki Morita Tatsuki Fukuie Yoshiyuki Yamada Yoshikazu Ohtsuka Katsuhiro Arai Yukihiro Ohya Hirohisa Saito Kenji Matsumoto Ichiro Nomura A nationwide survey of non-IgE-mediated gastrointestinal food allergies in neonates and infants Allergology International Eosinophilic gastrointestinal disorder (EGID) Food-protein-induced allergic proctocolitis (FPIAP) Food-protein-induced enterocolitis (FPIES) Food-protein-induced enteropathy (FPE) Non-IgE-mediated gastrointestinal food allergy (non-IgE-GIFA, non-IgE-GIFAs) |
| title | A nationwide survey of non-IgE-mediated gastrointestinal food allergies in neonates and infants |
| title_full | A nationwide survey of non-IgE-mediated gastrointestinal food allergies in neonates and infants |
| title_fullStr | A nationwide survey of non-IgE-mediated gastrointestinal food allergies in neonates and infants |
| title_full_unstemmed | A nationwide survey of non-IgE-mediated gastrointestinal food allergies in neonates and infants |
| title_short | A nationwide survey of non-IgE-mediated gastrointestinal food allergies in neonates and infants |
| title_sort | nationwide survey of non ige mediated gastrointestinal food allergies in neonates and infants |
| topic | Eosinophilic gastrointestinal disorder (EGID) Food-protein-induced allergic proctocolitis (FPIAP) Food-protein-induced enterocolitis (FPIES) Food-protein-induced enteropathy (FPE) Non-IgE-mediated gastrointestinal food allergy (non-IgE-GIFA, non-IgE-GIFAs) |
| url | http://www.sciencedirect.com/science/article/pii/S1323893023001077 |
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