Mechanical Characterization of Pharmaceutical Powders by Nanoindentation and Correlation with Their Behavior during Grinding
Controlling the size of powder particles is pivotal in the design of many pharmaceutical forms and the related manufacturing processes and plants. One of the most common techniques for particle size reduction in the process industry is powder milling, whose efficiency relates to the mechanical prope...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/14/6/1146 |
| _version_ | 1797483309709656064 |
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| author | Laura Baraldi Davide De Angelis Roberto Bosi Roberto Pennini Irene Bassanetti Andrea Benassi Guido Enrico Bellazzi |
| author_facet | Laura Baraldi Davide De Angelis Roberto Bosi Roberto Pennini Irene Bassanetti Andrea Benassi Guido Enrico Bellazzi |
| author_sort | Laura Baraldi |
| collection | DOAJ |
| description | Controlling the size of powder particles is pivotal in the design of many pharmaceutical forms and the related manufacturing processes and plants. One of the most common techniques for particle size reduction in the process industry is powder milling, whose efficiency relates to the mechanical properties of the powder particles themselves. In this work, we first characterize the elastic and plastic responses of different pharmaceutical powders by measuring their Young modulus, the hardness, and the brittleness index via nano-indentation. Subsequently, we analyze the behavior of those powder samples during comminution via jet mill in different process conditions. Finally, the correlation between the single particle mechanical properties and the milling process results is illustrated; the possibility to build a predictive model for powder grindability, based on nano-indentation data, is critically discussed. |
| first_indexed | 2024-03-09T22:46:08Z |
| format | Article |
| id | doaj.art-15fc8a0f423948e598405fb82a0bc3d6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T22:46:08Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-15fc8a0f423948e598405fb82a0bc3d62023-11-23T18:28:58ZengMDPI AGPharmaceutics1999-49232022-05-01146114610.3390/pharmaceutics14061146Mechanical Characterization of Pharmaceutical Powders by Nanoindentation and Correlation with Their Behavior during GrindingLaura Baraldi0Davide De Angelis1Roberto Bosi2Roberto Pennini3Irene Bassanetti4Andrea Benassi5Guido Enrico Bellazzi6Chiesi Farmaceutici S.p.A., Largo Belloli 11A, 43122 Parma, ItalyChiesi Farmaceutici S.p.A., Largo Belloli 11A, 43122 Parma, ItalyChiesi Farmaceutici S.p.A., Largo Belloli 11A, 43122 Parma, ItalyChiesi Farmaceutici S.p.A., Largo Belloli 11A, 43122 Parma, ItalyChiesi Farmaceutici S.p.A., Largo Belloli 11A, 43122 Parma, ItalyChiesi Farmaceutici S.p.A., Largo Belloli 11A, 43122 Parma, ItalyChiesi Farmaceutici S.p.A., Largo Belloli 11A, 43122 Parma, ItalyControlling the size of powder particles is pivotal in the design of many pharmaceutical forms and the related manufacturing processes and plants. One of the most common techniques for particle size reduction in the process industry is powder milling, whose efficiency relates to the mechanical properties of the powder particles themselves. In this work, we first characterize the elastic and plastic responses of different pharmaceutical powders by measuring their Young modulus, the hardness, and the brittleness index via nano-indentation. Subsequently, we analyze the behavior of those powder samples during comminution via jet mill in different process conditions. Finally, the correlation between the single particle mechanical properties and the milling process results is illustrated; the possibility to build a predictive model for powder grindability, based on nano-indentation data, is critically discussed.https://www.mdpi.com/1999-4923/14/6/1146Nanoindentationpowder grindingpharmaceutical powdersjet mill |
| spellingShingle | Laura Baraldi Davide De Angelis Roberto Bosi Roberto Pennini Irene Bassanetti Andrea Benassi Guido Enrico Bellazzi Mechanical Characterization of Pharmaceutical Powders by Nanoindentation and Correlation with Their Behavior during Grinding Pharmaceutics Nanoindentation powder grinding pharmaceutical powders jet mill |
| title | Mechanical Characterization of Pharmaceutical Powders by Nanoindentation and Correlation with Their Behavior during Grinding |
| title_full | Mechanical Characterization of Pharmaceutical Powders by Nanoindentation and Correlation with Their Behavior during Grinding |
| title_fullStr | Mechanical Characterization of Pharmaceutical Powders by Nanoindentation and Correlation with Their Behavior during Grinding |
| title_full_unstemmed | Mechanical Characterization of Pharmaceutical Powders by Nanoindentation and Correlation with Their Behavior during Grinding |
| title_short | Mechanical Characterization of Pharmaceutical Powders by Nanoindentation and Correlation with Their Behavior during Grinding |
| title_sort | mechanical characterization of pharmaceutical powders by nanoindentation and correlation with their behavior during grinding |
| topic | Nanoindentation powder grinding pharmaceutical powders jet mill |
| url | https://www.mdpi.com/1999-4923/14/6/1146 |
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