Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone

Inhibition of HDAC8 Reduces the Proliferation of Adult Neural Stem Cells in the Subventricular Zone

In the adult mammalian brain, neurons are produced from neural stem cells (NSCs) residing in two niches—the subventricular zone (SVZ), which forms the lining of the lateral ventricles, and the subgranular zone in the hippocampus. Epigenetic mechanisms contribute to maintaining distinct cell fates by...

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Bibliographic Details
Main Authors: Momoko Fukuda, Yuki Fujita, Yuko Hino, Mitsuyoshi Nakao, Katsuhiko Shirahige, Toshihide Yamashita
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
adult neurogenesis
neural stem cells
histone deacetylase 8 (HDAC8)
cytokine-mediated signaling
subventricular zone
Online Access:https://www.mdpi.com/1422-0067/25/5/2540

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