Cry1 expression during postnatal development is critical for the establishment of normal circadian period

Cry1 expression during postnatal development is critical for the establishment of normal circadian period

The mammalian circadian system generates an approximate 24-h rhythm through a complex autoregulatory feedback loop. Four genes, Period1 (Per1), Period2 (Per2), Cryptochrome1 (Cry1), and Cryptochrome2 (Cry2), regulate the negative feedback within this loop. Although these proteins have distinct roles...

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Bibliographic Details
Main Authors: Aaron E. Schirmer, Vivek Kumar, Andrew Schook, Eun Joo Song, Michael S. Marshall, Joseph S. Takahashi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Neuroscience
Subjects:
cryptochrome
circadian rhythms
period length
development
gene expression
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1166137/full

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