Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil
Ethnicity appears to play an important role in the prevalence and severity of hypertension, renal disease, and atherosclerosis. A cross-sectional study was conducted, including 206 Afro-descendants with hypertension, living in the remaining quilombo communities. These subjects underwent a carotid in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-10-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2018.1496932 |
| _version_ | 1818379815444545536 |
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| author | Dyego José de Araújo Brito Elisangela Milhomem dos Santos Raimunda Sheyla Carneiro Dias Isabela Leal Calado Gyl Eanes Barros Silva Joyce Santos Lages Francisco das Chagas Monteiro Júnior Alcione Miranda dos Santos Natalino Salgado Filho |
| author_facet | Dyego José de Araújo Brito Elisangela Milhomem dos Santos Raimunda Sheyla Carneiro Dias Isabela Leal Calado Gyl Eanes Barros Silva Joyce Santos Lages Francisco das Chagas Monteiro Júnior Alcione Miranda dos Santos Natalino Salgado Filho |
| author_sort | Dyego José de Araújo Brito |
| collection | DOAJ |
| description | Ethnicity appears to play an important role in the prevalence and severity of hypertension, renal disease, and atherosclerosis. A cross-sectional study was conducted, including 206 Afro-descendants with hypertension, living in the remaining quilombo communities. These subjects underwent a carotid intima-media thickness (CIMT) assessment. The presence of renal injury was assessed by: (1) The glomerular filtration rate (GFR) estimated by the formula CKD-EPI using creatinine and cystatin C and (2) Albuminuria (ACR ≥30 mg/g). The Poisson distribution model was set with robust variance to identify factors associated with carotid atherosclerosis. The statistical analysis was performed using the Stata 12.0 software, adopting a significance level of 5%. Most subjects were women (61.65%); the average age was 61.32 (±12.44) years. Subjects (12.62%) were identified with GFR <60 mL/min/1.73 m2 and 22.8% with albuminuria. Patients (59.22%) presented with a high CIMT. In the adjusted regression model, age ≥60 years (PR: 1.232 [CI 95%:1.091–1.390], p value = .001), ACR ≥30 mg/g (PR: 1.176 [CI 95%: 1.007–1.373], p = .040), and GFR/CKD-EPI using cystatin C (PR: 1.250 [CI 95%: 1.004–1.557], p = .045) were independently associated with carotid atherosclerosis. The occurrence of atherosclerotic lesions was high in the studied group. Age, albuminuria, and GFR (estimated by the formula CKD-EPI using cystatin C) influenced the prevalence of carotid atherosclerosis. |
| first_indexed | 2024-12-14T02:08:47Z |
| format | Article |
| id | doaj.art-15fd4a984093453d8c4319f82605810f |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-14T02:08:47Z |
| publishDate | 2018-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-15fd4a984093453d8c4319f82605810f2022-12-21T23:20:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492018-10-0140148349110.1080/0886022X.2018.14969321496932Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from BrazilDyego José de Araújo Brito0Elisangela Milhomem dos Santos1Raimunda Sheyla Carneiro Dias2Isabela Leal Calado3Gyl Eanes Barros Silva4Joyce Santos Lages5Francisco das Chagas Monteiro Júnior6Alcione Miranda dos Santos7Natalino Salgado Filho8Postgraduate Program of Health Science, Federal University of MaranhãoPostgraduate Program of Health Science, Federal University of MaranhãoPostgraduate Program of Health Science, Federal University of MaranhãoFederal University of MaranhãoFederal University of MaranhãoFederal University of MaranhãoUniversity Hospital of Federal University of MaranhãoPostgraduate Program of Health Science, Federal University of MaranhãoPostgraduate Program of Health Science, Federal University of MaranhãoEthnicity appears to play an important role in the prevalence and severity of hypertension, renal disease, and atherosclerosis. A cross-sectional study was conducted, including 206 Afro-descendants with hypertension, living in the remaining quilombo communities. These subjects underwent a carotid intima-media thickness (CIMT) assessment. The presence of renal injury was assessed by: (1) The glomerular filtration rate (GFR) estimated by the formula CKD-EPI using creatinine and cystatin C and (2) Albuminuria (ACR ≥30 mg/g). The Poisson distribution model was set with robust variance to identify factors associated with carotid atherosclerosis. The statistical analysis was performed using the Stata 12.0 software, adopting a significance level of 5%. Most subjects were women (61.65%); the average age was 61.32 (±12.44) years. Subjects (12.62%) were identified with GFR <60 mL/min/1.73 m2 and 22.8% with albuminuria. Patients (59.22%) presented with a high CIMT. In the adjusted regression model, age ≥60 years (PR: 1.232 [CI 95%:1.091–1.390], p value = .001), ACR ≥30 mg/g (PR: 1.176 [CI 95%: 1.007–1.373], p = .040), and GFR/CKD-EPI using cystatin C (PR: 1.250 [CI 95%: 1.004–1.557], p = .045) were independently associated with carotid atherosclerosis. The occurrence of atherosclerotic lesions was high in the studied group. Age, albuminuria, and GFR (estimated by the formula CKD-EPI using cystatin C) influenced the prevalence of carotid atherosclerosis.http://dx.doi.org/10.1080/0886022X.2018.1496932Renal damage markerscarotid atherosclerosishypertensionminority ethnic groupAfro-descendants |
| spellingShingle | Dyego José de Araújo Brito Elisangela Milhomem dos Santos Raimunda Sheyla Carneiro Dias Isabela Leal Calado Gyl Eanes Barros Silva Joyce Santos Lages Francisco das Chagas Monteiro Júnior Alcione Miranda dos Santos Natalino Salgado Filho Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil Renal Failure Renal damage markers carotid atherosclerosis hypertension minority ethnic group Afro-descendants |
| title | Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil |
| title_full | Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil |
| title_fullStr | Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil |
| title_full_unstemmed | Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil |
| title_short | Association between renal damage markers and carotid atherosclerosis in Afro-descendants with hypertension belonging to a minority ethnic group from Brazil |
| title_sort | association between renal damage markers and carotid atherosclerosis in afro descendants with hypertension belonging to a minority ethnic group from brazil |
| topic | Renal damage markers carotid atherosclerosis hypertension minority ethnic group Afro-descendants |
| url | http://dx.doi.org/10.1080/0886022X.2018.1496932 |
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