Interaction between Aβ and tau on reversion and conversion in mild cognitive impairment patients: After 2-year follow-up
Background: The role of amyloid-β (Aβ) and tau in reversion and conversion in patients with mild cognitive impairment (MCI) remains unclear. This study aimed to investigate the influence of cerebrospinal fluid (CSF) Aβ and tau on reversion and conversion and the temporal sequence of their pathogenic...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024028706 |
| _version_ | 1797259767652024320 |
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| author | Jinzhi Tang Qiuping Chen Zhenfa Fu Yuqun Liang Guohua Xu Huan Zhou Bingjie He |
| author_facet | Jinzhi Tang Qiuping Chen Zhenfa Fu Yuqun Liang Guohua Xu Huan Zhou Bingjie He |
| author_sort | Jinzhi Tang |
| collection | DOAJ |
| description | Background: The role of amyloid-β (Aβ) and tau in reversion and conversion in patients with mild cognitive impairment (MCI) remains unclear. This study aimed to investigate the influence of cerebrospinal fluid (CSF) Aβ and tau on reversion and conversion and the temporal sequence of their pathogenicity in MCI patients. Methods: 179 MCI patients were recruited from the Alzheimer's Disease Neuroimaging Initiative database and classified into two groups based on cognitive changes after follow-up: reversal group (MCI to cognitively normal) and conversion group (MCI to Alzheimer's disease). CSF biomarkers and cognitive function were measured at baseline and 2-year follow-up. Partial correlation was used to analyze the association between CSF biomarkers and cognitive function, and multivariable logistic regression to identify independent risk factors for cognitive changes at baseline and 2-year follow-up. Receiver operating characteristic (ROC) curves were utilized to evaluate the predictive ability of these risk factors for cognitive changes. Results: The differences in cognitive function and CSF biomarkers between the two groups remained consistent with baseline after 2-year follow-up. After controlling for confounding variables, there was still a correlation between CSF biomarkers and cognitive function at baseline and 2-year follow-up. Multivariable regression analysis found that at baseline, only Aβ level was independently associated with cognitive changes, while Aβ and tau were both predictive factors after 2-year follow-up. ROC curve analysis revealed that the combination of Aβ and tau [area under the curve (AUC) 0.91, sensitivity 84%, specificity 86%] in predicting cognitive changes after 2-year follow-up had better efficacy than baseline Aβ alone (AUC 0.81). Conclusion: Aβ may precede Tau in causing cognitive changes, and the interaction between the two mediates cognitive changes in patients. This study provides new clinical evidence to support the view that Aβ pathology precedes tau pathology, which together contribute to the changes in cognitive function. |
| first_indexed | 2024-03-07T14:00:45Z |
| format | Article |
| id | doaj.art-15fe09e283d948d5b12dde4e80bcd0a0 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T23:14:40Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-15fe09e283d948d5b12dde4e80bcd0a02024-03-17T07:56:27ZengElsevierHeliyon2405-84402024-03-01105e26839Interaction between Aβ and tau on reversion and conversion in mild cognitive impairment patients: After 2-year follow-upJinzhi Tang0Qiuping Chen1Zhenfa Fu2Yuqun Liang3Guohua Xu4Huan Zhou5Bingjie He6Neurological Function Examination Room, The First Affiliated Hospital of Jinan University, Guangzhou, PR ChinaNeurological Function Examination Room, The First Affiliated Hospital of Jinan University, Guangzhou, PR ChinaDepartment of Rehabilitation, Guangzhou Panyu Health Management Center (Guangzhou Panyu Rehabilitation Hospital), Guangzhou, PR ChinaDepartment of Rehabilitation, Guangzhou Panyu Health Management Center (Guangzhou Panyu Rehabilitation Hospital), Guangzhou, PR ChinaDepartment of Rehabilitation, Guangzhou Panyu Health Management Center (Guangzhou Panyu Rehabilitation Hospital), Guangzhou, PR ChinaNeurological Function Examination Room, The First Affiliated Hospital of Jinan University, Guangzhou, PR China; Corresponding author. Neurological Function Examination Room, The First Affiliated Hospital of Jinan University, No. 613, Huangpu Avenue West, Guangzhou, 510632, Guangdong, PR China.Department of Rehabilitation, Guangzhou Panyu Health Management Center (Guangzhou Panyu Rehabilitation Hospital), Guangzhou, PR China; Corresponding author. Department of Rehabilitation, Guangzhou Panyu Health Management Center (Guangzhou Panyu Rehabilitation Hospital), No. 688, Yushan West Road, Guangzhou, 511400, Guangdong, PR China.Background: The role of amyloid-β (Aβ) and tau in reversion and conversion in patients with mild cognitive impairment (MCI) remains unclear. This study aimed to investigate the influence of cerebrospinal fluid (CSF) Aβ and tau on reversion and conversion and the temporal sequence of their pathogenicity in MCI patients. Methods: 179 MCI patients were recruited from the Alzheimer's Disease Neuroimaging Initiative database and classified into two groups based on cognitive changes after follow-up: reversal group (MCI to cognitively normal) and conversion group (MCI to Alzheimer's disease). CSF biomarkers and cognitive function were measured at baseline and 2-year follow-up. Partial correlation was used to analyze the association between CSF biomarkers and cognitive function, and multivariable logistic regression to identify independent risk factors for cognitive changes at baseline and 2-year follow-up. Receiver operating characteristic (ROC) curves were utilized to evaluate the predictive ability of these risk factors for cognitive changes. Results: The differences in cognitive function and CSF biomarkers between the two groups remained consistent with baseline after 2-year follow-up. After controlling for confounding variables, there was still a correlation between CSF biomarkers and cognitive function at baseline and 2-year follow-up. Multivariable regression analysis found that at baseline, only Aβ level was independently associated with cognitive changes, while Aβ and tau were both predictive factors after 2-year follow-up. ROC curve analysis revealed that the combination of Aβ and tau [area under the curve (AUC) 0.91, sensitivity 84%, specificity 86%] in predicting cognitive changes after 2-year follow-up had better efficacy than baseline Aβ alone (AUC 0.81). Conclusion: Aβ may precede Tau in causing cognitive changes, and the interaction between the two mediates cognitive changes in patients. This study provides new clinical evidence to support the view that Aβ pathology precedes tau pathology, which together contribute to the changes in cognitive function.http://www.sciencedirect.com/science/article/pii/S2405844024028706Mild cognitive impairmentAmyloid-βTauReversionConversion |
| spellingShingle | Jinzhi Tang Qiuping Chen Zhenfa Fu Yuqun Liang Guohua Xu Huan Zhou Bingjie He Interaction between Aβ and tau on reversion and conversion in mild cognitive impairment patients: After 2-year follow-up Heliyon Mild cognitive impairment Amyloid-β Tau Reversion Conversion |
| title | Interaction between Aβ and tau on reversion and conversion in mild cognitive impairment patients: After 2-year follow-up |
| title_full | Interaction between Aβ and tau on reversion and conversion in mild cognitive impairment patients: After 2-year follow-up |
| title_fullStr | Interaction between Aβ and tau on reversion and conversion in mild cognitive impairment patients: After 2-year follow-up |
| title_full_unstemmed | Interaction between Aβ and tau on reversion and conversion in mild cognitive impairment patients: After 2-year follow-up |
| title_short | Interaction between Aβ and tau on reversion and conversion in mild cognitive impairment patients: After 2-year follow-up |
| title_sort | interaction between aβ and tau on reversion and conversion in mild cognitive impairment patients after 2 year follow up |
| topic | Mild cognitive impairment Amyloid-β Tau Reversion Conversion |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024028706 |
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