Involvement of Autophagy in Rat Tail Static Compression-Induced Intervertebral Disc Degeneration and Notochordal Cell Disappearance

Involvement of Autophagy in Rat Tail Static Compression-Induced Intervertebral Disc Degeneration and Notochordal Cell Disappearance

The intervertebral disc is the largest avascular low-nutrient organ in the body. Thus, resident cells may utilize autophagy, a stress-response survival mechanism, by self-digesting and recycling damaged components. Our objective was to elucidate the involvement of autophagy in rat experimental disc...

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Bibliographic Details
Main Authors: Takashi Yurube, Hiroaki Hirata, Masaaki Ito, Yoshiki Terashima, Yuji Kakiuchi, Ryosuke Kuroda, Kenichiro Kakutani
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
intervertebral disc degeneration
nucleus pulposus
notochordal cells
autophagy
apoptosis
nutrient deprivation
Online Access:https://www.mdpi.com/1422-0067/22/11/5648

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