The End of “One Size Fits All” Sepsis Therapies: Toward an Individualized Approach
Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to an infection, remains a major challenge for clinicians and trialists. Despite decades of research and multiple randomized clinical trials, a specific therapeutic for sepsis is not available. The evaluatio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/9/2260 |
| _version_ | 1827663160550621184 |
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| author | Jean-Louis Vincent Tom van der Poll John C. Marshall |
| author_facet | Jean-Louis Vincent Tom van der Poll John C. Marshall |
| author_sort | Jean-Louis Vincent |
| collection | DOAJ |
| description | Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to an infection, remains a major challenge for clinicians and trialists. Despite decades of research and multiple randomized clinical trials, a specific therapeutic for sepsis is not available. The evaluation of therapeutics targeting components of host response anomalies in patients with sepsis has been complicated by the inability to identify those in this very heterogeneous population who are more likely to benefit from a specific intervention. Additionally, multiple and diverse host response aberrations often co-exist in sepsis, and knowledge of which dysregulated biological organ system or pathway drives sepsis-induced pathology in an individual patient is limited, further complicating the development of effective therapies. Here, we discuss the drawbacks of previous attempts to develop sepsis therapeutics and delineate a future wherein interventions will be based on the host response profile of a patient. |
| first_indexed | 2024-03-10T00:38:01Z |
| format | Article |
| id | doaj.art-1601f5a1c3ef43738d25df09505d69db |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:38:01Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1601f5a1c3ef43738d25df09505d69db2023-11-23T15:11:50ZengMDPI AGBiomedicines2227-90592022-09-01109226010.3390/biomedicines10092260The End of “One Size Fits All” Sepsis Therapies: Toward an Individualized ApproachJean-Louis Vincent0Tom van der Poll1John C. Marshall2Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles, 1070 Brussels, BelgiumCenter of Experimental and Molecular Medicine, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The NetherlandsDepartments of Surgery and Critical Care Medicine, St. Michael’s Hospital, Toronto, ON M5B 1W8, CanadaSepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to an infection, remains a major challenge for clinicians and trialists. Despite decades of research and multiple randomized clinical trials, a specific therapeutic for sepsis is not available. The evaluation of therapeutics targeting components of host response anomalies in patients with sepsis has been complicated by the inability to identify those in this very heterogeneous population who are more likely to benefit from a specific intervention. Additionally, multiple and diverse host response aberrations often co-exist in sepsis, and knowledge of which dysregulated biological organ system or pathway drives sepsis-induced pathology in an individual patient is limited, further complicating the development of effective therapies. Here, we discuss the drawbacks of previous attempts to develop sepsis therapeutics and delineate a future wherein interventions will be based on the host response profile of a patient.https://www.mdpi.com/2227-9059/10/9/2260biomarkerhost responsepersonalized medicine |
| spellingShingle | Jean-Louis Vincent Tom van der Poll John C. Marshall The End of “One Size Fits All” Sepsis Therapies: Toward an Individualized Approach Biomedicines biomarker host response personalized medicine |
| title | The End of “One Size Fits All” Sepsis Therapies: Toward an Individualized Approach |
| title_full | The End of “One Size Fits All” Sepsis Therapies: Toward an Individualized Approach |
| title_fullStr | The End of “One Size Fits All” Sepsis Therapies: Toward an Individualized Approach |
| title_full_unstemmed | The End of “One Size Fits All” Sepsis Therapies: Toward an Individualized Approach |
| title_short | The End of “One Size Fits All” Sepsis Therapies: Toward an Individualized Approach |
| title_sort | end of one size fits all sepsis therapies toward an individualized approach |
| topic | biomarker host response personalized medicine |
| url | https://www.mdpi.com/2227-9059/10/9/2260 |
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