Immunostimulation using bacterial antigens – mechanism ofaction and clinical practice inviral respiratory tract infections
Recurrent respiratory tract infections constitute a significant problem in the practice of a general practitioner and paediatrician. Antibiotic resistance of bacterial strains, which has been growing for years, prompts the search for alternative ways of combating pathogens. One of them is the usag...
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| Format: | Article |
| Language: | English |
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Medical Communications Sp. z o.o.
2015-12-01
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| Series: | Pediatria i Medycyna Rodzinna |
| Subjects: | |
| Online Access: | http://www.pimr.pl/index.php/issues/2015-vol-11-no-4/immunostimulation-using-bacterial-antigens-mechanism-of-action-and-clinical-practice-in-viral-respiratory-tract-infections?aid=897 |
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| author | Wojciech Feleszko Marcin Dziekiewicz Adam Wąsowicz |
| author_facet | Wojciech Feleszko Marcin Dziekiewicz Adam Wąsowicz |
| author_sort | Wojciech Feleszko |
| collection | DOAJ |
| description | Recurrent respiratory tract infections constitute a significant problem in the practice of a general practitioner and
paediatrician. Antibiotic resistance of bacterial strains, which has been growing for years, prompts the search for alternative
ways of combating pathogens. One of them is the usage of preparations based on cell lysis of various bacterial strains.
Bacterial lysates have been available in Europe for many years. In preclinical trials, they are characterised by the capability
of reducing infections caused by bacteria and viruses that are not the components of the preparations. A range of clinical
trials have demonstrated their usefulness in reducing the frequency of seasonal respiratory tract infections and antibiotic use. Moreover, patients with chronic obstructive pulmonary disease gain an additional advantage in the form of the reduction
of the risk of hospitalization due to disease exacerbations and a positive influence on the survival curve. The action of bacterial
lysates is based on oral immunostimulation of gut-associated lymphoid tissue, which results in increased antibody production.
Moreover, they activate a range of mucosal mechanisms of non-specific immunity, mainly by enhancing the activity of TLR-dependent mechanisms. The efficacy of this group of drugs has been confirmed in a range of clinical trials, systematic
reviews and meta-analyses. Recent studies also indicate their immunoregulatory potential, suggesting that they might be
used in the future in preventing allergies, asthma and autoimmune diseases. To conclude, physicians (paediatricians,
laryngologists, pulmonologists) should consider reducing the use of antibiotics in their daily practice. Instead, they should
offer preparations that promote the immune system, thus controlling infections in a better way. |
| first_indexed | 2024-04-13T08:02:09Z |
| format | Article |
| id | doaj.art-16023dd5ba104828a29302560f7f0250 |
| institution | Directory Open Access Journal |
| issn | 1734-1531 2451-0742 |
| language | English |
| last_indexed | 2024-04-13T08:02:09Z |
| publishDate | 2015-12-01 |
| publisher | Medical Communications Sp. z o.o. |
| record_format | Article |
| series | Pediatria i Medycyna Rodzinna |
| spelling | doaj.art-16023dd5ba104828a29302560f7f02502022-12-22T02:55:15ZengMedical Communications Sp. z o.o.Pediatria i Medycyna Rodzinna1734-15312451-07422015-12-0111435836410.15557/PiMR.2015.0033Immunostimulation using bacterial antigens – mechanism ofaction and clinical practice inviral respiratory tract infectionsWojciech Feleszko0Marcin Dziekiewicz1Adam Wąsowicz2Department ofPaediatric Pneumonology and Allergology, Medical University ofWarsaw, PolandClinic of Gastroenterology and Child Nutrition, Medical University ofWarsaw, PolandDepartment ofPaediatric Pneumonology and Allergology, Medical University ofWarsaw, PolandRecurrent respiratory tract infections constitute a significant problem in the practice of a general practitioner and paediatrician. Antibiotic resistance of bacterial strains, which has been growing for years, prompts the search for alternative ways of combating pathogens. One of them is the usage of preparations based on cell lysis of various bacterial strains. Bacterial lysates have been available in Europe for many years. In preclinical trials, they are characterised by the capability of reducing infections caused by bacteria and viruses that are not the components of the preparations. A range of clinical trials have demonstrated their usefulness in reducing the frequency of seasonal respiratory tract infections and antibiotic use. Moreover, patients with chronic obstructive pulmonary disease gain an additional advantage in the form of the reduction of the risk of hospitalization due to disease exacerbations and a positive influence on the survival curve. The action of bacterial lysates is based on oral immunostimulation of gut-associated lymphoid tissue, which results in increased antibody production. Moreover, they activate a range of mucosal mechanisms of non-specific immunity, mainly by enhancing the activity of TLR-dependent mechanisms. The efficacy of this group of drugs has been confirmed in a range of clinical trials, systematic reviews and meta-analyses. Recent studies also indicate their immunoregulatory potential, suggesting that they might be used in the future in preventing allergies, asthma and autoimmune diseases. To conclude, physicians (paediatricians, laryngologists, pulmonologists) should consider reducing the use of antibiotics in their daily practice. Instead, they should offer preparations that promote the immune system, thus controlling infections in a better way.http://www.pimr.pl/index.php/issues/2015-vol-11-no-4/immunostimulation-using-bacterial-antigens-mechanism-of-action-and-clinical-practice-in-viral-respiratory-tract-infections?aid=897respiratory tract infectionsbacterial lysatesOM-85toll-like receptors |
| spellingShingle | Wojciech Feleszko Marcin Dziekiewicz Adam Wąsowicz Immunostimulation using bacterial antigens – mechanism ofaction and clinical practice inviral respiratory tract infections Pediatria i Medycyna Rodzinna respiratory tract infections bacterial lysates OM-85 toll-like receptors |
| title | Immunostimulation using bacterial antigens – mechanism ofaction and clinical practice inviral respiratory tract infections |
| title_full | Immunostimulation using bacterial antigens – mechanism ofaction and clinical practice inviral respiratory tract infections |
| title_fullStr | Immunostimulation using bacterial antigens – mechanism ofaction and clinical practice inviral respiratory tract infections |
| title_full_unstemmed | Immunostimulation using bacterial antigens – mechanism ofaction and clinical practice inviral respiratory tract infections |
| title_short | Immunostimulation using bacterial antigens – mechanism ofaction and clinical practice inviral respiratory tract infections |
| title_sort | immunostimulation using bacterial antigens mechanism ofaction and clinical practice inviral respiratory tract infections |
| topic | respiratory tract infections bacterial lysates OM-85 toll-like receptors |
| url | http://www.pimr.pl/index.php/issues/2015-vol-11-no-4/immunostimulation-using-bacterial-antigens-mechanism-of-action-and-clinical-practice-in-viral-respiratory-tract-infections?aid=897 |
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