Mucoadhesive drug delivery systems
Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of applicat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=1;spage=89;epage=100;aulast=Shaikh |
| _version_ | 1818995119862317056 |
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| author | Rahamatullah Shaikh Thakur Raghu Raj Singh Martin James Garland A David Woolfson Ryan F Donnelly |
| author_facet | Rahamatullah Shaikh Thakur Raghu Raj Singh Martin James Garland A David Woolfson Ryan F Donnelly |
| author_sort | Rahamatullah Shaikh |
| collection | DOAJ |
| description | Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal). |
| first_indexed | 2024-12-20T21:08:47Z |
| format | Article |
| id | doaj.art-1603fbdc5b23424cbbaf78a04b7b0ce3 |
| institution | Directory Open Access Journal |
| issn | 0975-7406 0976-4879 |
| language | English |
| last_indexed | 2024-12-20T21:08:47Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-1603fbdc5b23424cbbaf78a04b7b0ce32022-12-21T19:26:33ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74060976-48792011-01-01318910010.4103/0975-7406.76478Mucoadhesive drug delivery systemsRahamatullah ShaikhThakur Raghu Raj SinghMartin James GarlandA David WoolfsonRyan F DonnellyMucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal).http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=1;spage=89;epage=100;aulast=ShaikhMucoadhesionmucoadhesive drug delivery systemsmucoadhesive materials |
| spellingShingle | Rahamatullah Shaikh Thakur Raghu Raj Singh Martin James Garland A David Woolfson Ryan F Donnelly Mucoadhesive drug delivery systems Journal of Pharmacy and Bioallied Sciences Mucoadhesion mucoadhesive drug delivery systems mucoadhesive materials |
| title | Mucoadhesive drug delivery systems |
| title_full | Mucoadhesive drug delivery systems |
| title_fullStr | Mucoadhesive drug delivery systems |
| title_full_unstemmed | Mucoadhesive drug delivery systems |
| title_short | Mucoadhesive drug delivery systems |
| title_sort | mucoadhesive drug delivery systems |
| topic | Mucoadhesion mucoadhesive drug delivery systems mucoadhesive materials |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2011;volume=3;issue=1;spage=89;epage=100;aulast=Shaikh |
| work_keys_str_mv | AT rahamatullahshaikh mucoadhesivedrugdeliverysystems AT thakurraghurajsingh mucoadhesivedrugdeliverysystems AT martinjamesgarland mucoadhesivedrugdeliverysystems AT adavidwoolfson mucoadhesivedrugdeliverysystems AT ryanfdonnelly mucoadhesivedrugdeliverysystems |