Fenugreek (<i>Trigonella foenum-graecum</i> L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice
Fenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, fenugreek seeds are also recommended for geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidan...
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MDPI AG
2020-08-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/9/2552 |
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| author | Devesh Tewari Artur Jóźwik Małgorzata Łysek-Gładysińska Weronika Grzybek Wioletta Adamus-Białek Jacek Bicki Nina Strzałkowska Agnieszka Kamińska Olaf K. Horbańczuk Atanas G. Atanasov |
| author_facet | Devesh Tewari Artur Jóźwik Małgorzata Łysek-Gładysińska Weronika Grzybek Wioletta Adamus-Białek Jacek Bicki Nina Strzałkowska Agnieszka Kamińska Olaf K. Horbańczuk Atanas G. Atanasov |
| author_sort | Devesh Tewari |
| collection | DOAJ |
| description | Fenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, fenugreek seeds are also recommended for geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidant defense systems in aging mice. The study was conducted on 12-months aged mice which were given fenugreek seed dietary supplement. We evaluated the activities of various antioxidant defense enzymes such as superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx), and also estimated the phenolics and free radical scavenging properties in mice liver upon fenugreek supplementation. The estimation of SOD, GPx, and GR activities in aged mice liver revealed a significant (<i>p</i> < 0.01) difference among all the liver enzymes. Overall, this study reveals that fenugreek seed dietary supplementation has a positive effect on the activities of the hepatic antioxidant defense enzymes in the aged mice. |
| first_indexed | 2024-03-10T16:56:34Z |
| format | Article |
| id | doaj.art-160543032bf04b858cd28656aebfff4e |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T16:56:34Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-160543032bf04b858cd28656aebfff4e2023-11-20T11:06:21ZengMDPI AGNutrients2072-66432020-08-01129255210.3390/nu12092552Fenugreek (<i>Trigonella foenum-graecum</i> L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging MiceDevesh Tewari0Artur Jóźwik1Małgorzata Łysek-Gładysińska2Weronika Grzybek3Wioletta Adamus-Białek4Jacek Bicki5Nina Strzałkowska6Agnieszka Kamińska7Olaf K. Horbańczuk8Atanas G. Atanasov9Department of Pharmacognosy, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, IndiaInstitute of Genetics and Animal Biotechnology Polish Academy of Sciences, 05-552 Magdalenka, PolandDivision of Medical Biology, Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, PolandInstitute of Genetics and Animal Biotechnology Polish Academy of Sciences, 05-552 Magdalenka, PolandDepartment of Surgical Medicine with the Laboratory of Medical Genetics, Collegium Medicum, Jan Kochanowski University, al. IX Wieków Kielc 19A, 25-317 Kielce, PolandDepartment of Surgical Medicine with the Laboratory of Medical Genetics, Collegium Medicum, Jan Kochanowski University, al. IX Wieków Kielc 19A, 25-317 Kielce, PolandInstitute of Genetics and Animal Biotechnology Polish Academy of Sciences, 05-552 Magdalenka, PolandFaculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University, 01-815 Warsaw, PolandDepartment of Technique and Food Product Development, Warsaw University of Life Sciences (WULS-SGGW) 159c Nowoursynowska, 02-776 Warsaw, PolandInstitute of Genetics and Animal Biotechnology Polish Academy of Sciences, 05-552 Magdalenka, PolandFenugreek seeds are widely used in Asia and other places of the world for their nutritive and medicinal properties. In Asia, fenugreek seeds are also recommended for geriatric populations. Here, we evaluated for the first time the effect of fenugreek seed feed supplementation on the liver antioxidant defense systems in aging mice. The study was conducted on 12-months aged mice which were given fenugreek seed dietary supplement. We evaluated the activities of various antioxidant defense enzymes such as superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx), and also estimated the phenolics and free radical scavenging properties in mice liver upon fenugreek supplementation. The estimation of SOD, GPx, and GR activities in aged mice liver revealed a significant (<i>p</i> < 0.01) difference among all the liver enzymes. Overall, this study reveals that fenugreek seed dietary supplementation has a positive effect on the activities of the hepatic antioxidant defense enzymes in the aged mice.https://www.mdpi.com/2072-6643/12/9/2552fenugreekagingliverantioxidantsmice |
| spellingShingle | Devesh Tewari Artur Jóźwik Małgorzata Łysek-Gładysińska Weronika Grzybek Wioletta Adamus-Białek Jacek Bicki Nina Strzałkowska Agnieszka Kamińska Olaf K. Horbańczuk Atanas G. Atanasov Fenugreek (<i>Trigonella foenum-graecum</i> L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice Nutrients fenugreek aging liver antioxidants mice |
| title | Fenugreek (<i>Trigonella foenum-graecum</i> L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice |
| title_full | Fenugreek (<i>Trigonella foenum-graecum</i> L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice |
| title_fullStr | Fenugreek (<i>Trigonella foenum-graecum</i> L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice |
| title_full_unstemmed | Fenugreek (<i>Trigonella foenum-graecum</i> L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice |
| title_short | Fenugreek (<i>Trigonella foenum-graecum</i> L.) Seeds Dietary Supplementation Regulates Liver Antioxidant Defense Systems in Aging Mice |
| title_sort | fenugreek i trigonella foenum graecum i l seeds dietary supplementation regulates liver antioxidant defense systems in aging mice |
| topic | fenugreek aging liver antioxidants mice |
| url | https://www.mdpi.com/2072-6643/12/9/2552 |
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