P66Shc (Shc1) Zebrafish Mutant Line as a Platform for Testing Decreased Reactive Oxygen Species in Pathology

P66Shc (Shc1) Zebrafish Mutant Line as a Platform for Testing Decreased Reactive Oxygen Species in Pathology

Reactive oxygen species (ROS) dysregulation exacerbates many pathologies but must remain within normal ranges to maintain cell function. Since ROS-mediated pathology and routine cell function are coupled, in vivo models evaluating low-ROS background effects on pathology are limited. Some models alte...

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Bibliographic Details
Main Authors: Landon Haslem, Jennifer M. Hays, Xin A. Zhang, Franklin A. Hays
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
zebrafish
mitochondrial dysfunction
apoptosis
ischemia/reperfusion
myocardial infarction
p66Shc
Online Access:https://www.mdpi.com/2308-3425/9/11/385

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