Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only
Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep—the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characteri...
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MDPI AG
2021-01-01
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| Online Access: | https://www.mdpi.com/2076-2615/11/1/146 |
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| author | Ricardo de Miguel Javier Asín Ana Rodríguez-Largo Irache Echeverría Delia Lacasta Pedro Pinczowski Marina Gimeno Jéssica Molín Antonio Fernández Ignacio de Blas Damián de Andrés Marta Pérez Ramsés Reina Lluís Luján |
| author_facet | Ricardo de Miguel Javier Asín Ana Rodríguez-Largo Irache Echeverría Delia Lacasta Pedro Pinczowski Marina Gimeno Jéssica Molín Antonio Fernández Ignacio de Blas Damián de Andrés Marta Pérez Ramsés Reina Lluís Luján |
| author_sort | Ricardo de Miguel |
| collection | DOAJ |
| description | Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep—the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characterize the effects of the repetitive injection of Al-hydroxide containing products in lambs. Four flocks (Flocks 1–4; <i>n</i> = 21 each) kept under different conditions were studied. Three groups of seven lambs (Vaccine, Adjuvant-only, and Control) were established in each flock. Mild differences in average daily gain and fattening index were observed, indicating a reduced growth performance in Vaccine groups, likely related to short-term episodes of pyrexia and decreased daily intake. Clinical and hematological parameters remained within normal limits. Histology showed no significant differences between groups, although there was a tendency to present a higher frequency of hyperchromatic, shrunken neurons in the lumbar spinal cord in the Adjuvant-only group. Although Al-hydroxide was linked to granulomas at the injection site and behavioral changes in sheep, the results of the present experimental work indicate that injected Al-hydroxide is not enough to fully reproduce the wasting presentation of the ASIA syndrome. Other factors such as sex, breed, age, production system, diet or climate conditions could play a role. |
| first_indexed | 2024-03-09T05:12:39Z |
| format | Article |
| id | doaj.art-1605d40012ca4916b9caeb50fec06a9f |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T05:12:39Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-1605d40012ca4916b9caeb50fec06a9f2023-12-03T12:47:52ZengMDPI AGAnimals2076-26152021-01-0111114610.3390/ani11010146Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide OnlyRicardo de Miguel0Javier Asín1Ana Rodríguez-Largo2Irache Echeverría3Delia Lacasta4Pedro Pinczowski5Marina Gimeno6Jéssica Molín7Antonio Fernández8Ignacio de Blas9Damián de Andrés10Marta Pérez11Ramsés Reina12Lluís Luján13Department of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainDepartment of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainDepartment of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainInstitute of Agrobiotechnology, CSIC-Government of Navarra, 31192 Mutilva, SpainDepartment of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainDepartment of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainDepartment of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainDepartment of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainDepartment of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainDepartment of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainInstitute of Agrobiotechnology, CSIC-Government of Navarra, 31192 Mutilva, SpainDepartment of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainInstitute of Agrobiotechnology, CSIC-Government of Navarra, 31192 Mutilva, SpainDepartment of Animal Pathology, University of Zaragoza, 50013 Zaragoza, SpainAluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep—the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characterize the effects of the repetitive injection of Al-hydroxide containing products in lambs. Four flocks (Flocks 1–4; <i>n</i> = 21 each) kept under different conditions were studied. Three groups of seven lambs (Vaccine, Adjuvant-only, and Control) were established in each flock. Mild differences in average daily gain and fattening index were observed, indicating a reduced growth performance in Vaccine groups, likely related to short-term episodes of pyrexia and decreased daily intake. Clinical and hematological parameters remained within normal limits. Histology showed no significant differences between groups, although there was a tendency to present a higher frequency of hyperchromatic, shrunken neurons in the lumbar spinal cord in the Adjuvant-only group. Although Al-hydroxide was linked to granulomas at the injection site and behavioral changes in sheep, the results of the present experimental work indicate that injected Al-hydroxide is not enough to fully reproduce the wasting presentation of the ASIA syndrome. Other factors such as sex, breed, age, production system, diet or climate conditions could play a role.https://www.mdpi.com/2076-2615/11/1/146aluminum-hydroxidealuminum-based adjuvantaluminum-based vaccinegrowth performancehematology |
| spellingShingle | Ricardo de Miguel Javier Asín Ana Rodríguez-Largo Irache Echeverría Delia Lacasta Pedro Pinczowski Marina Gimeno Jéssica Molín Antonio Fernández Ignacio de Blas Damián de Andrés Marta Pérez Ramsés Reina Lluís Luján Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only Animals aluminum-hydroxide aluminum-based adjuvant aluminum-based vaccine growth performance hematology |
| title | Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only |
| title_full | Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only |
| title_fullStr | Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only |
| title_full_unstemmed | Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only |
| title_short | Growth Performance and Clinicopathological Analyses in Lambs Repetitively Inoculated with Aluminum-Hydroxide Containing Vaccines or Aluminum-Hydroxide Only |
| title_sort | growth performance and clinicopathological analyses in lambs repetitively inoculated with aluminum hydroxide containing vaccines or aluminum hydroxide only |
| topic | aluminum-hydroxide aluminum-based adjuvant aluminum-based vaccine growth performance hematology |
| url | https://www.mdpi.com/2076-2615/11/1/146 |
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