Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese
Background: Brachial-ankle pulse wave velocity (baPWV) is inversely associated with cognitive function. However, it is not known whether baPWV predicts cognitive decline (CD) in later life. We examined whether or not baPWV is an independent risk marker of subsequent CD in a population of older Japan...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Japan Epidemiological Association
2015-09-01
|
| Series: | Journal of Epidemiology |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jea/25/9/25_JE20140250/_pdf |
| _version_ | 1811256131254747136 |
|---|---|
| author | Yu Taniguchi Yoshinori Fujiwara Yu Nofuji Mariko Nishi Hiroshi Murayama Satoshi Seino Rika Tajima Yutaka Matsuyama Shoji Shinkai |
| author_facet | Yu Taniguchi Yoshinori Fujiwara Yu Nofuji Mariko Nishi Hiroshi Murayama Satoshi Seino Rika Tajima Yutaka Matsuyama Shoji Shinkai |
| author_sort | Yu Taniguchi |
| collection | DOAJ |
| description | Background: Brachial-ankle pulse wave velocity (baPWV) is inversely associated with cognitive function. However, it is not known whether baPWV predicts cognitive decline (CD) in later life. We examined whether or not baPWV is an independent risk marker of subsequent CD in a population of older Japanese.
Methods: Among 982 adults aged 65 years or older who participated in a baseline survey, 526 cognitively intact adults (Mini-Mental State Examination [MMSE] score ≥24; mean [SD] age, 71.7 [5.6] years; women, 57.8%) were followed for a period of up to 5 years. Pulse wave velocity was determined using an automated waveform analyser. Cognition was assessed by the MMSE, and CD was defined as a decrease of two points or more on the MMSE.
Results: During an average follow-up of 3.4 years, 85 participants (16.2%) developed CD. After controlling for important confounders, the odds ratios for CD in the highest and middle tertiles of baPWV, as compared with the lowest tertile, were 2.95 (95% confidence interval, 1.29–6.74) and 2.39 (95% confidence interval, 1.11–5.15), respectively.
Conclusions: High baPWV was an independent predictor of CD in a general population of older adults and may be useful in the clinical evaluation of elders. |
| first_indexed | 2024-04-12T17:35:28Z |
| format | Article |
| id | doaj.art-160942462568455a8e519304fdfceab1 |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-04-12T17:35:28Z |
| publishDate | 2015-09-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-160942462568455a8e519304fdfceab12022-12-22T03:22:59ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922015-09-0125959259910.2188/jea.JE20140250Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older JapaneseYu TaniguchiYoshinori FujiwaraYu NofujiMariko NishiHiroshi MurayamaSatoshi SeinoRika TajimaYutaka MatsuyamaShoji ShinkaiBackground: Brachial-ankle pulse wave velocity (baPWV) is inversely associated with cognitive function. However, it is not known whether baPWV predicts cognitive decline (CD) in later life. We examined whether or not baPWV is an independent risk marker of subsequent CD in a population of older Japanese. Methods: Among 982 adults aged 65 years or older who participated in a baseline survey, 526 cognitively intact adults (Mini-Mental State Examination [MMSE] score ≥24; mean [SD] age, 71.7 [5.6] years; women, 57.8%) were followed for a period of up to 5 years. Pulse wave velocity was determined using an automated waveform analyser. Cognition was assessed by the MMSE, and CD was defined as a decrease of two points or more on the MMSE. Results: During an average follow-up of 3.4 years, 85 participants (16.2%) developed CD. After controlling for important confounders, the odds ratios for CD in the highest and middle tertiles of baPWV, as compared with the lowest tertile, were 2.95 (95% confidence interval, 1.29–6.74) and 2.39 (95% confidence interval, 1.11–5.15), respectively. Conclusions: High baPWV was an independent predictor of CD in a general population of older adults and may be useful in the clinical evaluation of elders.https://www.jstage.jst.go.jp/article/jea/25/9/25_JE20140250/_pdfcognitive declinearterial stiffnessolder persons |
| spellingShingle | Yu Taniguchi Yoshinori Fujiwara Yu Nofuji Mariko Nishi Hiroshi Murayama Satoshi Seino Rika Tajima Yutaka Matsuyama Shoji Shinkai Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese Journal of Epidemiology cognitive decline arterial stiffness older persons |
| title | Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese |
| title_full | Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese |
| title_fullStr | Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese |
| title_full_unstemmed | Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese |
| title_short | Prospective Study of Arterial Stiffness and Subsequent Cognitive Decline Among Community-Dwelling Older Japanese |
| title_sort | prospective study of arterial stiffness and subsequent cognitive decline among community dwelling older japanese |
| topic | cognitive decline arterial stiffness older persons |
| url | https://www.jstage.jst.go.jp/article/jea/25/9/25_JE20140250/_pdf |
| work_keys_str_mv | AT yutaniguchi prospectivestudyofarterialstiffnessandsubsequentcognitivedeclineamongcommunitydwellingolderjapanese AT yoshinorifujiwara prospectivestudyofarterialstiffnessandsubsequentcognitivedeclineamongcommunitydwellingolderjapanese AT yunofuji prospectivestudyofarterialstiffnessandsubsequentcognitivedeclineamongcommunitydwellingolderjapanese AT marikonishi prospectivestudyofarterialstiffnessandsubsequentcognitivedeclineamongcommunitydwellingolderjapanese AT hiroshimurayama prospectivestudyofarterialstiffnessandsubsequentcognitivedeclineamongcommunitydwellingolderjapanese AT satoshiseino prospectivestudyofarterialstiffnessandsubsequentcognitivedeclineamongcommunitydwellingolderjapanese AT rikatajima prospectivestudyofarterialstiffnessandsubsequentcognitivedeclineamongcommunitydwellingolderjapanese AT yutakamatsuyama prospectivestudyofarterialstiffnessandsubsequentcognitivedeclineamongcommunitydwellingolderjapanese AT shojishinkai prospectivestudyofarterialstiffnessandsubsequentcognitivedeclineamongcommunitydwellingolderjapanese |