Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan
Abstract Background In health examinations for local inhabitants in cadmium-polluted areas, only healthy people are investigated, suggesting that patients with severe cadmium nephropathy or itai-itai disease may be overlooked. Therefore, we performed hospital-based screening to detect patients with...
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| Format: | Article |
| Language: | English |
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Komiyama Printing Co. Ltd
2019-01-01
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| Series: | Environmental Health and Preventive Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12199-019-0762-3 |
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| author | Toru Sasaki Hyogo Horiguchi Akira Arakawa Etsuko Oguma Atsushi Komatsuda Kenichi Sawada Katsuyuki Murata Kazuhito Yokoyama Takehisa Matsukawa Momoko Chiba Yuki Omori Norihiro Kamikomaki |
| author_facet | Toru Sasaki Hyogo Horiguchi Akira Arakawa Etsuko Oguma Atsushi Komatsuda Kenichi Sawada Katsuyuki Murata Kazuhito Yokoyama Takehisa Matsukawa Momoko Chiba Yuki Omori Norihiro Kamikomaki |
| author_sort | Toru Sasaki |
| collection | DOAJ |
| description | Abstract Background In health examinations for local inhabitants in cadmium-polluted areas, only healthy people are investigated, suggesting that patients with severe cadmium nephropathy or itai-itai disease may be overlooked. Therefore, we performed hospital-based screening to detect patients with cadmium nephropathy in two core medical institutes in cadmium-polluted areas in Akita prefecture, Japan. Methods Subjects for this screening were selected from patients aged 60 years or older with elevated serum creatinine levels and no definite renal diseases. We enrolled 35 subjects from a hospital in Odate city and 22 from a clinic in Kosaka town. Urinary ß2-microglobulin and blood and urinary cadmium levels were measured. Results The criteria for renal tubular dysfunction and the over-accumulation of cadmium were set as a urinary ß2-microglobulin level higher than 10,000 μg/g cr. and a blood cadmium level higher than 6 μg/L or urinary cadmium level higher than 10 μg/g cr., respectively. Subjects who fulfilled both criteria were diagnosed with cadmium nephropathy. Six out of 57 patients (10.5% of all subjects) had cadmium nephropathy. Conclusions This hospital-based screening is a very effective strategy for detecting patients with cadmium nephropathy in cadmium-polluted areas, playing a complementary role in health examinations for local inhabitants. Registration number No. 6, date of registration: 6 June, 2010 (Akita Rosai Hospital), and No. 1117, date of registration: 26 December, 2013 (Akita University). |
| first_indexed | 2024-12-10T22:00:05Z |
| format | Article |
| id | doaj.art-160950b06f784a32ad2e2e9bcbf9d0f2 |
| institution | Directory Open Access Journal |
| issn | 1342-078X 1347-4715 |
| language | English |
| last_indexed | 2024-12-10T22:00:05Z |
| publishDate | 2019-01-01 |
| publisher | Komiyama Printing Co. Ltd |
| record_format | Article |
| series | Environmental Health and Preventive Medicine |
| spelling | doaj.art-160950b06f784a32ad2e2e9bcbf9d0f22022-12-22T01:31:55ZengKomiyama Printing Co. LtdEnvironmental Health and Preventive Medicine1342-078X1347-47152019-01-012411810.1186/s12199-019-0762-3Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in JapanToru Sasaki0Hyogo Horiguchi1Akira Arakawa2Etsuko Oguma3Atsushi Komatsuda4Kenichi Sawada5Katsuyuki Murata6Kazuhito Yokoyama7Takehisa Matsukawa8Momoko Chiba9Yuki Omori10Norihiro Kamikomaki11Department of Internal Medicine, Akita Rosai Hospital, Japan Organization of Occupational Health and SafeDepartment of Hygiene, Kitasato University School of MedicineKosaka-machi ClinicDepartment of Hygiene, Kitasato University School of MedicineDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of MedicineDepartment of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of MedicineDepartment of Environmental Health Sciences, Akita University, Graduate School of MedicineDepartment of Epidemiology and Environmental Health, Juntendo University Faculty of MedicineDepartment of Epidemiology and Environmental Health, Juntendo University Faculty of MedicineDepartment of Epidemiology and Environmental Health, Juntendo University Faculty of MedicineDepartment of Hygiene, Kitasato University School of MedicineDepartment of Internal Medicine, Akita Rosai Hospital, Japan Organization of Occupational Health and SafeAbstract Background In health examinations for local inhabitants in cadmium-polluted areas, only healthy people are investigated, suggesting that patients with severe cadmium nephropathy or itai-itai disease may be overlooked. Therefore, we performed hospital-based screening to detect patients with cadmium nephropathy in two core medical institutes in cadmium-polluted areas in Akita prefecture, Japan. Methods Subjects for this screening were selected from patients aged 60 years or older with elevated serum creatinine levels and no definite renal diseases. We enrolled 35 subjects from a hospital in Odate city and 22 from a clinic in Kosaka town. Urinary ß2-microglobulin and blood and urinary cadmium levels were measured. Results The criteria for renal tubular dysfunction and the over-accumulation of cadmium were set as a urinary ß2-microglobulin level higher than 10,000 μg/g cr. and a blood cadmium level higher than 6 μg/L or urinary cadmium level higher than 10 μg/g cr., respectively. Subjects who fulfilled both criteria were diagnosed with cadmium nephropathy. Six out of 57 patients (10.5% of all subjects) had cadmium nephropathy. Conclusions This hospital-based screening is a very effective strategy for detecting patients with cadmium nephropathy in cadmium-polluted areas, playing a complementary role in health examinations for local inhabitants. Registration number No. 6, date of registration: 6 June, 2010 (Akita Rosai Hospital), and No. 1117, date of registration: 26 December, 2013 (Akita University).http://link.springer.com/article/10.1186/s12199-019-0762-3CadmiumNephropathyScreeningHospitalß2-microglobulin |
| spellingShingle | Toru Sasaki Hyogo Horiguchi Akira Arakawa Etsuko Oguma Atsushi Komatsuda Kenichi Sawada Katsuyuki Murata Kazuhito Yokoyama Takehisa Matsukawa Momoko Chiba Yuki Omori Norihiro Kamikomaki Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan Environmental Health and Preventive Medicine Cadmium Nephropathy Screening Hospital ß2-microglobulin |
| title | Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan |
| title_full | Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan |
| title_fullStr | Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan |
| title_full_unstemmed | Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan |
| title_short | Hospital-based screening to detect patients with cadmium nephropathy in cadmium-polluted areas in Japan |
| title_sort | hospital based screening to detect patients with cadmium nephropathy in cadmium polluted areas in japan |
| topic | Cadmium Nephropathy Screening Hospital ß2-microglobulin |
| url | http://link.springer.com/article/10.1186/s12199-019-0762-3 |
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