Identification of specific susceptibility loci for the early-onset colorectal cancer

Identification of specific susceptibility loci for the early-onset colorectal cancer

Abstract Background The incidence of early-onset colorectal cancer (EOCRC; patients < 50 years old) has been rising rapidly, whereas the EOCRC genetic susceptibility remains incompletely investigated. Here, we aimed to systematically identify specific susceptible genetic variants for EOCRC. Metho...

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Bibliographic Details
Main Authors: Haoxue Wang, Yimin Cai, Meng Jin, Chao Qun Huang, Caibo Ning, Siyuan Niu, Linyun Fan, Bin Li, Ming Zhang, Zequn Lu, Xuesi Dong, Zilin Luo, Rong Zhong, Heng Li, Ying Zhu, Xiaoping Miao, Xiaojun Yang, Jiang Chang, Ni Li, Jianbo Tian
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Genome Medicine
Subjects:
GWAS
Early-onset CRC
Genetic variants
PRS
POLA2
Online Access:https://doi.org/10.1186/s13073-023-01163-w

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