Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS‐HD study
Abstract Introduction To determine if cardiovascular risk factor (CVRF) burden is associated with Alzheimer's disease (AD) biomarkers and whether they synergistically associate with cognition. Methods We cross‐sectionally studied 1521 non‐demented Mexican American (52%) and non‐Hispanic White i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12394 |
| _version_ | 1797857598422122496 |
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| author | Xiaqing Jiang Sid E. O'Bryant Leigh A. Johnson Robert A. Rissman Kristine Yaffe The Health and Aging Brain Study (HABS‐HD) Study Team |
| author_facet | Xiaqing Jiang Sid E. O'Bryant Leigh A. Johnson Robert A. Rissman Kristine Yaffe The Health and Aging Brain Study (HABS‐HD) Study Team |
| author_sort | Xiaqing Jiang |
| collection | DOAJ |
| description | Abstract Introduction To determine if cardiovascular risk factor (CVRF) burden is associated with Alzheimer's disease (AD) biomarkers and whether they synergistically associate with cognition. Methods We cross‐sectionally studied 1521 non‐demented Mexican American (52%) and non‐Hispanic White individuals aged ≥50 years. A composite score was calculated by averaging the z‐scores of five cognitive tests. Plasma β‐amyloid (Aβ) 42/40, total tau (t‐tau), and neurofilament light (NfL) were assayed using Simoa. CVRF burden was assessed using the Framingham Risk Score (FRS). Results Compared to low FRS (< 10% risk), high FRS (≥ 20% risk) was independently associated with increased t‐tau and NfL. High FRS was significantly associated with higher NfL only among Mexican American individuals. Intermediate or high FRS (vs. low FRS) were independently associated with lower cognition, and the association remained significant after adjusting for plasma biomarkers. Hypertension synergistically interacted with t‐tau and NfL (p < 0.05). Discussion CVRFs play critical roles, both through independent and neurodegenerative pathways, on cognition. |
| first_indexed | 2024-04-09T20:59:19Z |
| format | Article |
| id | doaj.art-160a849e3c3f459cafaf2ea4b2d8f1ef |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-09T20:59:19Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-160a849e3c3f459cafaf2ea4b2d8f1ef2023-03-29T11:42:33ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292023-01-01151n/an/a10.1002/dad2.12394Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS‐HD studyXiaqing Jiang0Sid E. O'Bryant1Leigh A. Johnson2Robert A. Rissman3Kristine Yaffe4The Health and Aging Brain Study (HABS‐HD) Study TeamDepartment of Psychiatry and Behavioral Sciences University of California San Francisco San Francisco California USAInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USAInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USADepartment of Neurosciences University of California San Diego California USADepartment of Psychiatry and Behavioral Sciences University of California San Francisco San Francisco California USAAbstract Introduction To determine if cardiovascular risk factor (CVRF) burden is associated with Alzheimer's disease (AD) biomarkers and whether they synergistically associate with cognition. Methods We cross‐sectionally studied 1521 non‐demented Mexican American (52%) and non‐Hispanic White individuals aged ≥50 years. A composite score was calculated by averaging the z‐scores of five cognitive tests. Plasma β‐amyloid (Aβ) 42/40, total tau (t‐tau), and neurofilament light (NfL) were assayed using Simoa. CVRF burden was assessed using the Framingham Risk Score (FRS). Results Compared to low FRS (< 10% risk), high FRS (≥ 20% risk) was independently associated with increased t‐tau and NfL. High FRS was significantly associated with higher NfL only among Mexican American individuals. Intermediate or high FRS (vs. low FRS) were independently associated with lower cognition, and the association remained significant after adjusting for plasma biomarkers. Hypertension synergistically interacted with t‐tau and NfL (p < 0.05). Discussion CVRFs play critical roles, both through independent and neurodegenerative pathways, on cognition.https://doi.org/10.1002/dad2.12394amyloidblood biomarkerscardiovascular risk factorscognitionHispanicMexican American |
| spellingShingle | Xiaqing Jiang Sid E. O'Bryant Leigh A. Johnson Robert A. Rissman Kristine Yaffe The Health and Aging Brain Study (HABS‐HD) Study Team Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS‐HD study Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring amyloid blood biomarkers cardiovascular risk factors cognition Hispanic Mexican American |
| title | Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS‐HD study |
| title_full | Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS‐HD study |
| title_fullStr | Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS‐HD study |
| title_full_unstemmed | Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS‐HD study |
| title_short | Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS‐HD study |
| title_sort | association of cardiovascular risk factors and blood biomarkers with cognition the habs hd study |
| topic | amyloid blood biomarkers cardiovascular risk factors cognition Hispanic Mexican American |
| url | https://doi.org/10.1002/dad2.12394 |
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