Functional Characterization of <i>FH</i> Mutation c.557G>A Underlies Uterine Leiomyomas
The <i>FH</i> gene encodes the fumarate hydratase of the Krebs cycle and functions as a homotetramer to catalyze the hydration of fumarate to malate. Mutations in <i>FH</i> result in uterine leiomyomas, a rare autosomal dominant inherited metabolic disease. However, how <i...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-01-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/3/1452 |