Glucose and Lipid Metabolism Abnormalities among Patients with Autosomal Dominant Polycystic Kidney Disease
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent monogenic renal disease with a prevalence of 1:1,000 births and it is the 4th most common cause of dialysis-dependent end-stage renal disease (ESDR). Recent reports suggest an association between APDKD and metab...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2019-11-01
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| Series: | Kidney & Blood Pressure Research |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/503423 |
| _version_ | 1818520319804047360 |
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| author | Magda Fliszkiewicz Mariusz Niemczyk Andrzej Kulesza Anna Łabuś Leszek Pączek |
| author_facet | Magda Fliszkiewicz Mariusz Niemczyk Andrzej Kulesza Anna Łabuś Leszek Pączek |
| author_sort | Magda Fliszkiewicz |
| collection | DOAJ |
| description | Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent monogenic renal disease with a prevalence of 1:1,000 births and it is the 4th most common cause of dialysis-dependent end-stage renal disease (ESDR). Recent reports suggest an association between APDKD and metabolic derangements, particularly impaired glucose metabolism. Methods: In this cross-sectional study we analyzed data obtained from case records of 189 patients with ADPKD, including kidney transplant recipients, managed in an outpatient department. Results: The mean BMI was 25.4 ± 3.9; 25.25 before and 27.7 after transplantation. A fasting glucose level above 100 mg/dL (5.6 mmol/L) was observed in 60 patients (29%) – 27% without transplantation and 41% kidney transplant recipients. Diabetes mellitus was diagnosed in 17 patients (8.9%), including 3 (2.3%) without a history of transplantation and 14 (24.1%) after kidney transplantation (p < 0.01). We observed dyslipidemia in 30% and hyperuricemia in 53% of patients. Conclusion: Demonstrated metabolic abnormalities should be considered in maintenance of ADPKD patients, including kidney transplant recipients. |
| first_indexed | 2024-12-11T01:35:45Z |
| format | Article |
| id | doaj.art-160bf631a27e42cb864251f53e7244e9 |
| institution | Directory Open Access Journal |
| issn | 1420-4096 1423-0143 |
| language | English |
| last_indexed | 2024-12-11T01:35:45Z |
| publishDate | 2019-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney & Blood Pressure Research |
| spelling | doaj.art-160bf631a27e42cb864251f53e7244e92022-12-22T01:25:12ZengKarger PublishersKidney & Blood Pressure Research1420-40961423-01432019-11-014461416142210.1159/000503423503423Glucose and Lipid Metabolism Abnormalities among Patients with Autosomal Dominant Polycystic Kidney DiseaseMagda FliszkiewiczMariusz NiemczykAndrzej KuleszaAnna ŁabuśLeszek PączekIntroduction: Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent monogenic renal disease with a prevalence of 1:1,000 births and it is the 4th most common cause of dialysis-dependent end-stage renal disease (ESDR). Recent reports suggest an association between APDKD and metabolic derangements, particularly impaired glucose metabolism. Methods: In this cross-sectional study we analyzed data obtained from case records of 189 patients with ADPKD, including kidney transplant recipients, managed in an outpatient department. Results: The mean BMI was 25.4 ± 3.9; 25.25 before and 27.7 after transplantation. A fasting glucose level above 100 mg/dL (5.6 mmol/L) was observed in 60 patients (29%) – 27% without transplantation and 41% kidney transplant recipients. Diabetes mellitus was diagnosed in 17 patients (8.9%), including 3 (2.3%) without a history of transplantation and 14 (24.1%) after kidney transplantation (p < 0.01). We observed dyslipidemia in 30% and hyperuricemia in 53% of patients. Conclusion: Demonstrated metabolic abnormalities should be considered in maintenance of ADPKD patients, including kidney transplant recipients.https://www.karger.com/Article/FullText/503423autosomal dominant polycystic kidney diseasediabetes mellituskidney transplant |
| spellingShingle | Magda Fliszkiewicz Mariusz Niemczyk Andrzej Kulesza Anna Łabuś Leszek Pączek Glucose and Lipid Metabolism Abnormalities among Patients with Autosomal Dominant Polycystic Kidney Disease Kidney & Blood Pressure Research autosomal dominant polycystic kidney disease diabetes mellitus kidney transplant |
| title | Glucose and Lipid Metabolism Abnormalities among Patients with Autosomal Dominant Polycystic Kidney Disease |
| title_full | Glucose and Lipid Metabolism Abnormalities among Patients with Autosomal Dominant Polycystic Kidney Disease |
| title_fullStr | Glucose and Lipid Metabolism Abnormalities among Patients with Autosomal Dominant Polycystic Kidney Disease |
| title_full_unstemmed | Glucose and Lipid Metabolism Abnormalities among Patients with Autosomal Dominant Polycystic Kidney Disease |
| title_short | Glucose and Lipid Metabolism Abnormalities among Patients with Autosomal Dominant Polycystic Kidney Disease |
| title_sort | glucose and lipid metabolism abnormalities among patients with autosomal dominant polycystic kidney disease |
| topic | autosomal dominant polycystic kidney disease diabetes mellitus kidney transplant |
| url | https://www.karger.com/Article/FullText/503423 |
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