Possible benefits of evaluation the coefficient of variation of active substance of a drug from different manufactures based on benzydamine hydrochloride example
Acute respiratory viral infection (ARVI) is one of the most common causes of morbidity in Russia. The incidence rate is high regardless of age or social group [1]. Sore throat is the most common symptom during ARVI, prevalence rate is 95%[2]. Symptomatic treatment of ARVI requires the use of various...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2019-04-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/2962 |
| _version_ | 1797842080621395968 |
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| author | V. V. Smirnov E. A. Egorenkov |
| author_facet | V. V. Smirnov E. A. Egorenkov |
| author_sort | V. V. Smirnov |
| collection | DOAJ |
| description | Acute respiratory viral infection (ARVI) is one of the most common causes of morbidity in Russia. The incidence rate is high regardless of age or social group [1]. Sore throat is the most common symptom during ARVI, prevalence rate is 95%[2]. Symptomatic treatment of ARVI requires the use of various drugs, including drugs for pain in the throat. Such preparations are widely represented on the market, while they have a different form and different composition. One of the most popular are sprays containing benzydamine hydrochloride. Professional associations recommend using Benzydamine hydrochloridewhile sore throat, also in paediatric practice [3].In connection with a large number of generics, the issue of standardization of such sprays is topical. To compare the range of the actual concentration of the active substance in interchangeable preparations with different trade names, a comparative determination of the concentrations of benzydamine hydrochloride in sprays of 4 trade names was carried out in 6 different series in each. The quantitative determination was carried out by HPLC with a UV detector. As a result, the active substance concentration ranges were determined in 6 batches of the preparation of each trade name, and the coefficient of variation of concentrations was calculated and conclusions were made on the difference in the indicated indices among preparations of various manufacturers. |
| first_indexed | 2024-04-09T16:41:57Z |
| format | Article |
| id | doaj.art-160c86764f584277926a50391ca9cccf |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:41:57Z |
| publishDate | 2019-04-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-160c86764f584277926a50391ca9cccf2023-04-23T06:56:37ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902019-04-010810210410.21518/2079-701X-2019-8-102-1042881Possible benefits of evaluation the coefficient of variation of active substance of a drug from different manufactures based on benzydamine hydrochloride exampleV. V. Smirnov0E. A. Egorenkov1Federal State Budgetary Institution «State Scientific Center «Institute of Immunology» of the Federal Medical-Biological AgencyFederal State Budgetary Institution «State Scientific Center «Institute of Immunology» of the Federal Medical-Biological AgencyAcute respiratory viral infection (ARVI) is one of the most common causes of morbidity in Russia. The incidence rate is high regardless of age or social group [1]. Sore throat is the most common symptom during ARVI, prevalence rate is 95%[2]. Symptomatic treatment of ARVI requires the use of various drugs, including drugs for pain in the throat. Such preparations are widely represented on the market, while they have a different form and different composition. One of the most popular are sprays containing benzydamine hydrochloride. Professional associations recommend using Benzydamine hydrochloridewhile sore throat, also in paediatric practice [3].In connection with a large number of generics, the issue of standardization of such sprays is topical. To compare the range of the actual concentration of the active substance in interchangeable preparations with different trade names, a comparative determination of the concentrations of benzydamine hydrochloride in sprays of 4 trade names was carried out in 6 different series in each. The quantitative determination was carried out by HPLC with a UV detector. As a result, the active substance concentration ranges were determined in 6 batches of the preparation of each trade name, and the coefficient of variation of concentrations was calculated and conclusions were made on the difference in the indicated indices among preparations of various manufacturers.https://www.med-sovet.pro/jour/article/view/2962arvigenericbenzydaminethroat sprayhplc-uv |
| spellingShingle | V. V. Smirnov E. A. Egorenkov Possible benefits of evaluation the coefficient of variation of active substance of a drug from different manufactures based on benzydamine hydrochloride example Медицинский совет arvi generic benzydamine throat spray hplc-uv |
| title | Possible benefits of evaluation the coefficient of variation of active substance of a drug from different manufactures based on benzydamine hydrochloride example |
| title_full | Possible benefits of evaluation the coefficient of variation of active substance of a drug from different manufactures based on benzydamine hydrochloride example |
| title_fullStr | Possible benefits of evaluation the coefficient of variation of active substance of a drug from different manufactures based on benzydamine hydrochloride example |
| title_full_unstemmed | Possible benefits of evaluation the coefficient of variation of active substance of a drug from different manufactures based on benzydamine hydrochloride example |
| title_short | Possible benefits of evaluation the coefficient of variation of active substance of a drug from different manufactures based on benzydamine hydrochloride example |
| title_sort | possible benefits of evaluation the coefficient of variation of active substance of a drug from different manufactures based on benzydamine hydrochloride example |
| topic | arvi generic benzydamine throat spray hplc-uv |
| url | https://www.med-sovet.pro/jour/article/view/2962 |
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