Synthesis and Anticancer Evaluation of 4-Chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol Analogues: An Insight into Experimental and Theoretical Studies

Synthesis and Anticancer Evaluation of 4-Chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol Analogues: An Insight into Experimental and Theoretical Studies

We report herein the synthesis, docking studies and biological evaluation of a series of new 4-chloro-2-((5-aryl-1,3,4-oxadiazol-2-yl)amino)phenol analogues (<b>6a-h</b>). The new compounds were designed based on the oxadiazole-linked aryl core of tubulin inhibitors of IMC-038525 and IMC...

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Bibliographic Details
Main Authors: Obaid Afzal, Amena Ali, Abuzer Ali, Abdulmalik Saleh Alfawaz Altamimi, Manal A. Alossaimi, Md Afroz Bakht, Salahuddin, Mubarak A. Alamri, Md. Faiyaz Ahsan, Mohamed Jawed Ahsan
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Molecules
Subjects:
anticancer
antibacterial
DNA gyrase
molecular docking
1,3,4-oxadiazole
tubulin
Online Access:https://www.mdpi.com/1420-3049/28/16/6086

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