Optical Coherence Tomography as a Biomarker in the Differential Diagnosis between Parkinson’s Disease and Atypical Parkinsonian Syndromes: A Narrative Review
Parkinsonism may be a clinical manifestation of a wide range of disease entities, and still poses a great diagnostic challenge. In an attempt to provide further insight into the differential diagnosis of PD versus progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal dege...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/14/6/2491 |
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| author | Stella Karatzetzou Dimitrios Parisis Serafeim Ioannidis Theodora Afrantou Panagiotis Ioannidis |
| author_facet | Stella Karatzetzou Dimitrios Parisis Serafeim Ioannidis Theodora Afrantou Panagiotis Ioannidis |
| author_sort | Stella Karatzetzou |
| collection | DOAJ |
| description | Parkinsonism may be a clinical manifestation of a wide range of disease entities, and still poses a great diagnostic challenge. In an attempt to provide further insight into the differential diagnosis of PD versus progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and Lewy body dementia (LBD), several biomarkers have been investigated, yielding inconclusive results, OCT being among them. The present review aims to explore the potential diagnostic value of evaluating retinal parameters through OCT implementation among patients presenting with a Parkinsonian syndrome, with an emphasis on effective differentiation between distinct syndromes. Having reviewed all the available literature published within the last decade, neurodegeneration seems to be paralleled with degeneration and alterations of the retina that may be quantified by OCT. Specific patterns of structural changes within the retina may provide valuable information on the underlying pathology, thus highlighting the role of OCT as a diagnostic tool within this group of patients. Although still not utilized in clinical practice, OCT, if further explored and validated, may significantly enhance overall Parkinsonism care. |
| first_indexed | 2024-04-24T18:34:03Z |
| format | Article |
| id | doaj.art-160d1969d9ae49f788754e4f09b3ece4 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-04-24T18:34:03Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-160d1969d9ae49f788754e4f09b3ece42024-03-27T13:19:53ZengMDPI AGApplied Sciences2076-34172024-03-01146249110.3390/app14062491Optical Coherence Tomography as a Biomarker in the Differential Diagnosis between Parkinson’s Disease and Atypical Parkinsonian Syndromes: A Narrative ReviewStella Karatzetzou0Dimitrios Parisis1Serafeim Ioannidis2Theodora Afrantou3Panagiotis Ioannidis42nd Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, 546 36 Thessaloniki, Greece2nd Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, 546 36 Thessaloniki, GreeceSchool of Medicine, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece2nd Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, 546 36 Thessaloniki, Greece2nd Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, 546 36 Thessaloniki, GreeceParkinsonism may be a clinical manifestation of a wide range of disease entities, and still poses a great diagnostic challenge. In an attempt to provide further insight into the differential diagnosis of PD versus progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and Lewy body dementia (LBD), several biomarkers have been investigated, yielding inconclusive results, OCT being among them. The present review aims to explore the potential diagnostic value of evaluating retinal parameters through OCT implementation among patients presenting with a Parkinsonian syndrome, with an emphasis on effective differentiation between distinct syndromes. Having reviewed all the available literature published within the last decade, neurodegeneration seems to be paralleled with degeneration and alterations of the retina that may be quantified by OCT. Specific patterns of structural changes within the retina may provide valuable information on the underlying pathology, thus highlighting the role of OCT as a diagnostic tool within this group of patients. Although still not utilized in clinical practice, OCT, if further explored and validated, may significantly enhance overall Parkinsonism care.https://www.mdpi.com/2076-3417/14/6/2491optical coherence tomographyOCTParkinsonismatypical Parkinsonian syndromesParkinson’s diseaseprogressive supranuclear palsy |
| spellingShingle | Stella Karatzetzou Dimitrios Parisis Serafeim Ioannidis Theodora Afrantou Panagiotis Ioannidis Optical Coherence Tomography as a Biomarker in the Differential Diagnosis between Parkinson’s Disease and Atypical Parkinsonian Syndromes: A Narrative Review Applied Sciences optical coherence tomography OCT Parkinsonism atypical Parkinsonian syndromes Parkinson’s disease progressive supranuclear palsy |
| title | Optical Coherence Tomography as a Biomarker in the Differential Diagnosis between Parkinson’s Disease and Atypical Parkinsonian Syndromes: A Narrative Review |
| title_full | Optical Coherence Tomography as a Biomarker in the Differential Diagnosis between Parkinson’s Disease and Atypical Parkinsonian Syndromes: A Narrative Review |
| title_fullStr | Optical Coherence Tomography as a Biomarker in the Differential Diagnosis between Parkinson’s Disease and Atypical Parkinsonian Syndromes: A Narrative Review |
| title_full_unstemmed | Optical Coherence Tomography as a Biomarker in the Differential Diagnosis between Parkinson’s Disease and Atypical Parkinsonian Syndromes: A Narrative Review |
| title_short | Optical Coherence Tomography as a Biomarker in the Differential Diagnosis between Parkinson’s Disease and Atypical Parkinsonian Syndromes: A Narrative Review |
| title_sort | optical coherence tomography as a biomarker in the differential diagnosis between parkinson s disease and atypical parkinsonian syndromes a narrative review |
| topic | optical coherence tomography OCT Parkinsonism atypical Parkinsonian syndromes Parkinson’s disease progressive supranuclear palsy |
| url | https://www.mdpi.com/2076-3417/14/6/2491 |
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