Patient and clinician characteristics and preferences for increasing participation in placebo surgery trials: a scoping review of attributes to inform a discrete choice experiment
Abstract Background Orthopaedic surgeries include some of the highest volume surgical interventions globally; however, studies have shown that a significant proportion of patients report no clinically meaningful improvement in pain or function after certain procedures. As a result, there is increasi...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Trials |
| Online Access: | https://doi.org/10.1186/s13063-022-06277-x |
| _version_ | 1828378814564007936 |
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| author | Madeleine Hinwood Laura Wall Danielle Lang Zsolt J. Balogh Angela Smith Michelle Dowsey Phillip Clarke Peter Choong Samantha Bunzli Francesco Paolucci |
| author_facet | Madeleine Hinwood Laura Wall Danielle Lang Zsolt J. Balogh Angela Smith Michelle Dowsey Phillip Clarke Peter Choong Samantha Bunzli Francesco Paolucci |
| author_sort | Madeleine Hinwood |
| collection | DOAJ |
| description | Abstract Background Orthopaedic surgeries include some of the highest volume surgical interventions globally; however, studies have shown that a significant proportion of patients report no clinically meaningful improvement in pain or function after certain procedures. As a result, there is increasing interest in conducting randomised placebo-controlled trials in orthopaedic surgery. However, these frequently fail to reach recruitment targets suggesting a need to improve trial design to encourage participation. The objective of this study was to systematically scope the available evidence on patient and clinician values and preferences which may influence the decision to participate in placebo surgery trial. Methods A systematic review was conducted via a literature search in the MEDLINE, Embase, PsycInfo, CINAHL, and EconLit databases as of 19 July 2021, for studies of any design (except commentaries or opinion pieces) based on two key concepts: patient and clinician characteristics, values and preferences, and placebo surgery trials. Results Of 3424 initial articles, we retained 18 eligible studies. Characteristics, preferences, values, and attitudes of patients (including levels of pain/function, risk/benefit perception, and altruism) and of clinicians (including concerns regarding patient deception associated with placebo, and experience/training in research) influenced their decisions to participate in placebo-controlled trials. Furthermore, some aspects of trial design, including randomisation procedures, availability of the procedure outside of the trial, and the information and consent procedures used, also influenced decisions to participate. Conclusion Participant recruitment is a significant challenge in placebo surgery trials, and individual decisions to participate appear to be sensitive to preferences around treatment. Understanding and quantifying the role patient and clinician preferences may play in surgical trials may contribute to the optimisation of the design and implementation of clinical trials in surgery. |
| first_indexed | 2024-12-10T03:28:38Z |
| format | Article |
| id | doaj.art-161069ed7f59483c8d207e376361cedb |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-10T03:28:38Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-161069ed7f59483c8d207e376361cedb2022-12-22T02:03:52ZengBMCTrials1745-62152022-04-0123111610.1186/s13063-022-06277-xPatient and clinician characteristics and preferences for increasing participation in placebo surgery trials: a scoping review of attributes to inform a discrete choice experimentMadeleine Hinwood0Laura Wall1Danielle Lang2Zsolt J. Balogh3Angela Smith4Michelle Dowsey5Phillip Clarke6Peter Choong7Samantha Bunzli8Francesco Paolucci9School of Medicine and Public Health, University of NewcastleNewcastle Business School, University of NewcastleSchool of Medicine and Public Health, University of NewcastleDepartment of Traumatology, John Hunter Hospital and the University of NewcastleHunter New England Local Health DistrictDepartment of Surgery, St Vincent’s Hospital, University of Melbourne, AustraliaSchool of Population and Global Health, University of Melbourne, AustraliaDepartment of Surgery, St Vincent’s Hospital, University of Melbourne, AustraliaDepartment of Surgery, St Vincent’s Hospital, University of Melbourne, AustraliaNewcastle Business School, University of NewcastleAbstract Background Orthopaedic surgeries include some of the highest volume surgical interventions globally; however, studies have shown that a significant proportion of patients report no clinically meaningful improvement in pain or function after certain procedures. As a result, there is increasing interest in conducting randomised placebo-controlled trials in orthopaedic surgery. However, these frequently fail to reach recruitment targets suggesting a need to improve trial design to encourage participation. The objective of this study was to systematically scope the available evidence on patient and clinician values and preferences which may influence the decision to participate in placebo surgery trial. Methods A systematic review was conducted via a literature search in the MEDLINE, Embase, PsycInfo, CINAHL, and EconLit databases as of 19 July 2021, for studies of any design (except commentaries or opinion pieces) based on two key concepts: patient and clinician characteristics, values and preferences, and placebo surgery trials. Results Of 3424 initial articles, we retained 18 eligible studies. Characteristics, preferences, values, and attitudes of patients (including levels of pain/function, risk/benefit perception, and altruism) and of clinicians (including concerns regarding patient deception associated with placebo, and experience/training in research) influenced their decisions to participate in placebo-controlled trials. Furthermore, some aspects of trial design, including randomisation procedures, availability of the procedure outside of the trial, and the information and consent procedures used, also influenced decisions to participate. Conclusion Participant recruitment is a significant challenge in placebo surgery trials, and individual decisions to participate appear to be sensitive to preferences around treatment. Understanding and quantifying the role patient and clinician preferences may play in surgical trials may contribute to the optimisation of the design and implementation of clinical trials in surgery.https://doi.org/10.1186/s13063-022-06277-x |
| spellingShingle | Madeleine Hinwood Laura Wall Danielle Lang Zsolt J. Balogh Angela Smith Michelle Dowsey Phillip Clarke Peter Choong Samantha Bunzli Francesco Paolucci Patient and clinician characteristics and preferences for increasing participation in placebo surgery trials: a scoping review of attributes to inform a discrete choice experiment Trials |
| title | Patient and clinician characteristics and preferences for increasing participation in placebo surgery trials: a scoping review of attributes to inform a discrete choice experiment |
| title_full | Patient and clinician characteristics and preferences for increasing participation in placebo surgery trials: a scoping review of attributes to inform a discrete choice experiment |
| title_fullStr | Patient and clinician characteristics and preferences for increasing participation in placebo surgery trials: a scoping review of attributes to inform a discrete choice experiment |
| title_full_unstemmed | Patient and clinician characteristics and preferences for increasing participation in placebo surgery trials: a scoping review of attributes to inform a discrete choice experiment |
| title_short | Patient and clinician characteristics and preferences for increasing participation in placebo surgery trials: a scoping review of attributes to inform a discrete choice experiment |
| title_sort | patient and clinician characteristics and preferences for increasing participation in placebo surgery trials a scoping review of attributes to inform a discrete choice experiment |
| url | https://doi.org/10.1186/s13063-022-06277-x |
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