EDA ligand triggers plasma membrane trafficking of its receptor EDAR via PKA activation and SNAP23-containing complexes

EDA ligand triggers plasma membrane trafficking of its receptor EDAR via PKA activation and SNAP23-containing complexes

Abstract Background Ectodysplasin-A (EDA), a skin-specific TNF ligand, interacts with its membrane receptor EDAR to trigger EDA signaling in skin appendage formation. Gene mutations in EDA signaling cause Anhidrotic/Hypohidrotic Ectodermal Dysplasia (A/HED), which affects the formation of skin appen...

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Bibliographic Details
Main Authors: Yuyuan Yao, Ruihan Yang, Jian Zhu, David Schlessinger, Jian Sima
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cell & Bioscience
Subjects:
EDA
EDAR
Membrane trafficking
HED
TNFR
Online Access:https://doi.org/10.1186/s13578-023-01082-8

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