Necroptosis is associated with Rab27‐independent expulsion of extracellular vesicles containing RIPK3 and MLKL

Necroptosis is associated with Rab27‐independent expulsion of extracellular vesicles containing RIPK3 and MLKL

Abstract Extracellular vesicle (EV) secretion is an important mechanism used by cells to release biomolecules. A common necroptosis effector—mixed lineage kinase domain like (MLKL)—was recently found to participate in the biogenesis of small and large EVs independent of its function in necroptosis....

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Bibliographic Details
Main Authors: Kartik Gupta, Kyle A. Brown, Marvin L. Hsieh, Brandon M. Hoover, Jianxin Wang, Mitri K. Khoury, Vijaya Satish Sekhar Pilli, Reagan S. H. Beyer, Nihal R. Voruganti, Sahil Chaudhary, David S. Roberts, Regina M. Murphy, Seungpyo Hong, Ying Ge, Bo Liu
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Journal of Extracellular Vesicles
Subjects:
lysosomal exocytosis
MLKL
necroptosis
proteomics
RIPK3
SEVs
Online Access:https://doi.org/10.1002/jev2.12261

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