The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people

Background: Epidemiological studies about the effect of essential metal mixture on fasting plasma glucose (FPG) levels among elderly people are sparse. The object of this study was to examine the associations of single essential metals and essential metal mixture with FPG levels in Chinese community...

Full description

Bibliographic Details
Main Authors: Pan-pan Wang, Jing-yuan Lei, Yuan Wang, Hong-li Wang, Liang Sun, Bing Hu, Su-fang Wang, Dong-mei Zhang, Gui-mei Chen, Chun-mei Liang, Fang-biao Tao, Lin-sheng Yang, Qing-si Wu
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323007935
_version_ 1797683182927085568
author Pan-pan Wang
Jing-yuan Lei
Yuan Wang
Hong-li Wang
Liang Sun
Bing Hu
Su-fang Wang
Dong-mei Zhang
Gui-mei Chen
Chun-mei Liang
Fang-biao Tao
Lin-sheng Yang
Qing-si Wu
author_facet Pan-pan Wang
Jing-yuan Lei
Yuan Wang
Hong-li Wang
Liang Sun
Bing Hu
Su-fang Wang
Dong-mei Zhang
Gui-mei Chen
Chun-mei Liang
Fang-biao Tao
Lin-sheng Yang
Qing-si Wu
author_sort Pan-pan Wang
collection DOAJ
description Background: Epidemiological studies about the effect of essential metal mixture on fasting plasma glucose (FPG) levels among elderly people are sparse. The object of this study was to examine the associations of single essential metals and essential metal mixture with FPG levels in Chinese community-dwelling elderly people. Methods: The study recruited 2348 community-dwelling elderly people in total. Inductively coupled plasma-mass spectrometry was adopted to detect the levels of vanadium (V), selenium (Se), magnesium (Mg), cobalt (Co), calcium (Ca), and molybdenum (Mo) in urine. The relationships between single essential metals and essential metal mixture and FPG levels were evaluated by linear regression and Bayesian kernel machine regression (BKMR) models, respectively. Results: In multiple-metal linear regression models, urine V and Mg were negatively related to the FPG levels (β = − 0.016, 95 % CI: − 0.030 to − 0.003 for V; β = − 0.021, 95 % CI: − 0.033 to − 0.009 for Mg), and urine Se was positively related to the FPG levels (β = 0.024, 95 % CI: 0.014–0.034). In BKMR model, the significant relationships of Se and Mg with the FPG levels were also found. The essential metal mixture was negatively associated with FPG levels in a dose-response pattern, and Mg had the maximum posterior inclusion probability (PIP) value (PIP = 1.0000), followed by Se (PIP = 0.9968). Besides, Co showed a significant association with decreased FPG levels in older adults without hyperlipemia and in women. Conclusions: Both Mg and Se were associated with FPG levels, individually and as a mixture. The essential metal mixture displayed a linear dose-response relationship with reduced FPG levels, with Mg having the largest contribution to FPG levels, followed by Se. Further prospective investigations are necessary to validate these exploratory findings.
first_indexed 2024-03-12T00:10:49Z
format Article
id doaj.art-1614d9bef4d848d9b02072c84f77446a
institution Directory Open Access Journal
issn 0147-6513
language English
last_indexed 2024-03-12T00:10:49Z
publishDate 2023-09-01
publisher Elsevier
record_format Article
series Ecotoxicology and Environmental Safety
spelling doaj.art-1614d9bef4d848d9b02072c84f77446a2023-09-16T05:28:26ZengElsevierEcotoxicology and Environmental Safety0147-65132023-09-01263115289The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly peoplePan-pan Wang0Jing-yuan Lei1Yuan Wang2Hong-li Wang3Liang Sun4Bing Hu5Su-fang Wang6Dong-mei Zhang7Gui-mei Chen8Chun-mei Liang9Fang-biao Tao10Lin-sheng Yang11Qing-si Wu12School of Public Health, Department of Health Inspection and Quarantine, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Public Health, Department of Health Inspection and Quarantine, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei 230032, Anhui, ChinaFuyang Center for Diseases Prevention and Control, Fuyang 236069, Anhui, ChinaFuyang Center for Diseases Prevention and Control, Fuyang 236069, Anhui, ChinaSchool of Public Health, Department of Nutrition and Food Hygiene, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Health Services Management, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Health Services Management, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Public Health, Department of Health Inspection and Quarantine, Anhui Medical University, Hefei 230032, Anhui, ChinaMOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), No. 81 Meishan Road, Hefei 230032, Anhui, ChinaSchool of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei 230032, Anhui, China; Corresponding authors.Department of Blood Transfusion, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui, China; Corresponding authors.Background: Epidemiological studies about the effect of essential metal mixture on fasting plasma glucose (FPG) levels among elderly people are sparse. The object of this study was to examine the associations of single essential metals and essential metal mixture with FPG levels in Chinese community-dwelling elderly people. Methods: The study recruited 2348 community-dwelling elderly people in total. Inductively coupled plasma-mass spectrometry was adopted to detect the levels of vanadium (V), selenium (Se), magnesium (Mg), cobalt (Co), calcium (Ca), and molybdenum (Mo) in urine. The relationships between single essential metals and essential metal mixture and FPG levels were evaluated by linear regression and Bayesian kernel machine regression (BKMR) models, respectively. Results: In multiple-metal linear regression models, urine V and Mg were negatively related to the FPG levels (β = − 0.016, 95 % CI: − 0.030 to − 0.003 for V; β = − 0.021, 95 % CI: − 0.033 to − 0.009 for Mg), and urine Se was positively related to the FPG levels (β = 0.024, 95 % CI: 0.014–0.034). In BKMR model, the significant relationships of Se and Mg with the FPG levels were also found. The essential metal mixture was negatively associated with FPG levels in a dose-response pattern, and Mg had the maximum posterior inclusion probability (PIP) value (PIP = 1.0000), followed by Se (PIP = 0.9968). Besides, Co showed a significant association with decreased FPG levels in older adults without hyperlipemia and in women. Conclusions: Both Mg and Se were associated with FPG levels, individually and as a mixture. The essential metal mixture displayed a linear dose-response relationship with reduced FPG levels, with Mg having the largest contribution to FPG levels, followed by Se. Further prospective investigations are necessary to validate these exploratory findings.http://www.sciencedirect.com/science/article/pii/S0147651323007935Essential metal mixtureFasting blood glucoseElderly peopleBayesian kernel machine regression
spellingShingle Pan-pan Wang
Jing-yuan Lei
Yuan Wang
Hong-li Wang
Liang Sun
Bing Hu
Su-fang Wang
Dong-mei Zhang
Gui-mei Chen
Chun-mei Liang
Fang-biao Tao
Lin-sheng Yang
Qing-si Wu
The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people
Ecotoxicology and Environmental Safety
Essential metal mixture
Fasting blood glucose
Elderly people
Bayesian kernel machine regression
title The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people
title_full The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people
title_fullStr The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people
title_full_unstemmed The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people
title_short The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people
title_sort association between the essential metal mixture and fasting plasma glucose in chinese community dwelling elderly people
topic Essential metal mixture
Fasting blood glucose
Elderly people
Bayesian kernel machine regression
url http://www.sciencedirect.com/science/article/pii/S0147651323007935
work_keys_str_mv AT panpanwang theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT jingyuanlei theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT yuanwang theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT hongliwang theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT liangsun theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT binghu theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT sufangwang theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT dongmeizhang theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT guimeichen theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT chunmeiliang theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT fangbiaotao theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT linshengyang theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT qingsiwu theassociationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT panpanwang associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT jingyuanlei associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT yuanwang associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT hongliwang associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT liangsun associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT binghu associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT sufangwang associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT dongmeizhang associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT guimeichen associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT chunmeiliang associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT fangbiaotao associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT linshengyang associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople
AT qingsiwu associationbetweentheessentialmetalmixtureandfastingplasmaglucoseinchinesecommunitydwellingelderlypeople