The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people
Background: Epidemiological studies about the effect of essential metal mixture on fasting plasma glucose (FPG) levels among elderly people are sparse. The object of this study was to examine the associations of single essential metals and essential metal mixture with FPG levels in Chinese community...
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Elsevier
2023-09-01
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Series: | Ecotoxicology and Environmental Safety |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651323007935 |
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author | Pan-pan Wang Jing-yuan Lei Yuan Wang Hong-li Wang Liang Sun Bing Hu Su-fang Wang Dong-mei Zhang Gui-mei Chen Chun-mei Liang Fang-biao Tao Lin-sheng Yang Qing-si Wu |
author_facet | Pan-pan Wang Jing-yuan Lei Yuan Wang Hong-li Wang Liang Sun Bing Hu Su-fang Wang Dong-mei Zhang Gui-mei Chen Chun-mei Liang Fang-biao Tao Lin-sheng Yang Qing-si Wu |
author_sort | Pan-pan Wang |
collection | DOAJ |
description | Background: Epidemiological studies about the effect of essential metal mixture on fasting plasma glucose (FPG) levels among elderly people are sparse. The object of this study was to examine the associations of single essential metals and essential metal mixture with FPG levels in Chinese community-dwelling elderly people. Methods: The study recruited 2348 community-dwelling elderly people in total. Inductively coupled plasma-mass spectrometry was adopted to detect the levels of vanadium (V), selenium (Se), magnesium (Mg), cobalt (Co), calcium (Ca), and molybdenum (Mo) in urine. The relationships between single essential metals and essential metal mixture and FPG levels were evaluated by linear regression and Bayesian kernel machine regression (BKMR) models, respectively. Results: In multiple-metal linear regression models, urine V and Mg were negatively related to the FPG levels (β = − 0.016, 95 % CI: − 0.030 to − 0.003 for V; β = − 0.021, 95 % CI: − 0.033 to − 0.009 for Mg), and urine Se was positively related to the FPG levels (β = 0.024, 95 % CI: 0.014–0.034). In BKMR model, the significant relationships of Se and Mg with the FPG levels were also found. The essential metal mixture was negatively associated with FPG levels in a dose-response pattern, and Mg had the maximum posterior inclusion probability (PIP) value (PIP = 1.0000), followed by Se (PIP = 0.9968). Besides, Co showed a significant association with decreased FPG levels in older adults without hyperlipemia and in women. Conclusions: Both Mg and Se were associated with FPG levels, individually and as a mixture. The essential metal mixture displayed a linear dose-response relationship with reduced FPG levels, with Mg having the largest contribution to FPG levels, followed by Se. Further prospective investigations are necessary to validate these exploratory findings. |
first_indexed | 2024-03-12T00:10:49Z |
format | Article |
id | doaj.art-1614d9bef4d848d9b02072c84f77446a |
institution | Directory Open Access Journal |
issn | 0147-6513 |
language | English |
last_indexed | 2024-03-12T00:10:49Z |
publishDate | 2023-09-01 |
publisher | Elsevier |
record_format | Article |
series | Ecotoxicology and Environmental Safety |
spelling | doaj.art-1614d9bef4d848d9b02072c84f77446a2023-09-16T05:28:26ZengElsevierEcotoxicology and Environmental Safety0147-65132023-09-01263115289The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly peoplePan-pan Wang0Jing-yuan Lei1Yuan Wang2Hong-li Wang3Liang Sun4Bing Hu5Su-fang Wang6Dong-mei Zhang7Gui-mei Chen8Chun-mei Liang9Fang-biao Tao10Lin-sheng Yang11Qing-si Wu12School of Public Health, Department of Health Inspection and Quarantine, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Public Health, Department of Health Inspection and Quarantine, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei 230032, Anhui, ChinaFuyang Center for Diseases Prevention and Control, Fuyang 236069, Anhui, ChinaFuyang Center for Diseases Prevention and Control, Fuyang 236069, Anhui, ChinaSchool of Public Health, Department of Nutrition and Food Hygiene, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Health Services Management, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Health Services Management, Anhui Medical University, Hefei 230032, Anhui, ChinaSchool of Public Health, Department of Health Inspection and Quarantine, Anhui Medical University, Hefei 230032, Anhui, ChinaMOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), No. 81 Meishan Road, Hefei 230032, Anhui, ChinaSchool of Public Health, Department of Epidemiology and Health Statistics, Anhui Medical University, Hefei 230032, Anhui, China; Corresponding authors.Department of Blood Transfusion, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui, China; Corresponding authors.Background: Epidemiological studies about the effect of essential metal mixture on fasting plasma glucose (FPG) levels among elderly people are sparse. The object of this study was to examine the associations of single essential metals and essential metal mixture with FPG levels in Chinese community-dwelling elderly people. Methods: The study recruited 2348 community-dwelling elderly people in total. Inductively coupled plasma-mass spectrometry was adopted to detect the levels of vanadium (V), selenium (Se), magnesium (Mg), cobalt (Co), calcium (Ca), and molybdenum (Mo) in urine. The relationships between single essential metals and essential metal mixture and FPG levels were evaluated by linear regression and Bayesian kernel machine regression (BKMR) models, respectively. Results: In multiple-metal linear regression models, urine V and Mg were negatively related to the FPG levels (β = − 0.016, 95 % CI: − 0.030 to − 0.003 for V; β = − 0.021, 95 % CI: − 0.033 to − 0.009 for Mg), and urine Se was positively related to the FPG levels (β = 0.024, 95 % CI: 0.014–0.034). In BKMR model, the significant relationships of Se and Mg with the FPG levels were also found. The essential metal mixture was negatively associated with FPG levels in a dose-response pattern, and Mg had the maximum posterior inclusion probability (PIP) value (PIP = 1.0000), followed by Se (PIP = 0.9968). Besides, Co showed a significant association with decreased FPG levels in older adults without hyperlipemia and in women. Conclusions: Both Mg and Se were associated with FPG levels, individually and as a mixture. The essential metal mixture displayed a linear dose-response relationship with reduced FPG levels, with Mg having the largest contribution to FPG levels, followed by Se. Further prospective investigations are necessary to validate these exploratory findings.http://www.sciencedirect.com/science/article/pii/S0147651323007935Essential metal mixtureFasting blood glucoseElderly peopleBayesian kernel machine regression |
spellingShingle | Pan-pan Wang Jing-yuan Lei Yuan Wang Hong-li Wang Liang Sun Bing Hu Su-fang Wang Dong-mei Zhang Gui-mei Chen Chun-mei Liang Fang-biao Tao Lin-sheng Yang Qing-si Wu The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people Ecotoxicology and Environmental Safety Essential metal mixture Fasting blood glucose Elderly people Bayesian kernel machine regression |
title | The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people |
title_full | The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people |
title_fullStr | The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people |
title_full_unstemmed | The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people |
title_short | The association between the essential metal mixture and fasting plasma glucose in Chinese community-dwelling elderly people |
title_sort | association between the essential metal mixture and fasting plasma glucose in chinese community dwelling elderly people |
topic | Essential metal mixture Fasting blood glucose Elderly people Bayesian kernel machine regression |
url | http://www.sciencedirect.com/science/article/pii/S0147651323007935 |
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