Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?
A tumorigenic microenvironment can give rise to neoplasm. A shift from this condition to a tumor-suppressive microenvironment is of significant benefit to susceptible individuals. The carbonyl groups of glycine and valine have long bond lengths, consequently generating potent affinities to divalent...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-08-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/1073274820954453 |
| _version_ | 1797772221098229760 |
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| author | Shanshan An MS Sirui Yan BS Ying Zhang MS Huan Xu BS Tao Gan PhD Qiuyun Liu PhD |
| author_facet | Shanshan An MS Sirui Yan BS Ying Zhang MS Huan Xu BS Tao Gan PhD Qiuyun Liu PhD |
| author_sort | Shanshan An MS |
| collection | DOAJ |
| description | A tumorigenic microenvironment can give rise to neoplasm. A shift from this condition to a tumor-suppressive microenvironment is of significant benefit to susceptible individuals. The carbonyl groups of glycine and valine have long bond lengths, consequently generating potent affinities to divalent cations such as calcium. We hypothesize that the formation of insoluble and rigid calcium oxalate augmented by glycine and valine counteracts strong acids such as HCl chemically, thus reducing cancer risks. The anticancer effects of the 2 amino acids can be explained from a chemical and biochemical perspective. A tumor-suppressive microenvironment could be established via the modification of the proteome without genome editing at the DNA level. |
| first_indexed | 2024-03-12T21:47:54Z |
| format | Article |
| id | doaj.art-1614e03af934487e9fbca40e27d6939a |
| institution | Directory Open Access Journal |
| issn | 1073-2748 |
| language | English |
| last_indexed | 2024-03-12T21:47:54Z |
| publishDate | 2020-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-1614e03af934487e9fbca40e27d6939a2023-07-26T07:03:55ZengSAGE PublishingCancer Control1073-27482020-08-012710.1177/1073274820954453Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement?Shanshan An MS0Sirui Yan BS1Ying Zhang MS2Huan Xu BS3Tao Gan PhD4Qiuyun Liu PhD5 School of Life Sciences, , Guangzhou, China School of Life Sciences, , Guangzhou, China , Guangzhou, China School of Electronic Information and Automation, , Guilin, Guangxi, China School of Basic Medicine, , Jiangxi, China School of Life Sciences, , Guangzhou, ChinaA tumorigenic microenvironment can give rise to neoplasm. A shift from this condition to a tumor-suppressive microenvironment is of significant benefit to susceptible individuals. The carbonyl groups of glycine and valine have long bond lengths, consequently generating potent affinities to divalent cations such as calcium. We hypothesize that the formation of insoluble and rigid calcium oxalate augmented by glycine and valine counteracts strong acids such as HCl chemically, thus reducing cancer risks. The anticancer effects of the 2 amino acids can be explained from a chemical and biochemical perspective. A tumor-suppressive microenvironment could be established via the modification of the proteome without genome editing at the DNA level.https://doi.org/10.1177/1073274820954453 |
| spellingShingle | Shanshan An MS Sirui Yan BS Ying Zhang MS Huan Xu BS Tao Gan PhD Qiuyun Liu PhD Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement? Cancer Control |
| title | Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement? |
| title_full | Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement? |
| title_fullStr | Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement? |
| title_full_unstemmed | Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement? |
| title_short | Is It Possible to Establish a Tumor-Suppressive Microenvironment With Glycine and Valine Supplement? |
| title_sort | is it possible to establish a tumor suppressive microenvironment with glycine and valine supplement |
| url | https://doi.org/10.1177/1073274820954453 |
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