Endocardial botulinum toxin injection into ganglionated plexi in order to reduce atrial fibrillation inducibility
<p>Objective. Prior animal studies suggest that botulinum toxin injection into the epicardial fat pads can suppress atrial fibrillation (AF) inducibility. The purpose of the present study was to assess the efficacy and safety of endocardial botulinum toxin injection into epicardial fat pads an...
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| Format: | Article |
| Language: | English |
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Meshalkin National Medical Research Center
2016-01-01
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| Series: | Патология кровообращения и кардиохирургия |
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| Online Access: | http://journalmeshalkin.ru/index.php/heartjournal/article/view/271 |
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| author | А. Г. Стрельников А. А. Якубов Д. С. Сергеевичев С. Н. Артеменко И. Л. Михеенко С. А. Абашкин А. Б. Романов Е. А. Покушалов |
| author_facet | А. Г. Стрельников А. А. Якубов Д. С. Сергеевичев С. Н. Артеменко И. Л. Михеенко С. А. Абашкин А. Б. Романов Е. А. Покушалов |
| author_sort | А. Г. Стрельников |
| collection | DOAJ |
| description | <p>Objective. Prior animal studies suggest that botulinum toxin injection into the epicardial fat pads can suppress atrial fibrillation (AF) inducibility. The purpose of the present study was to assess the efficacy and safety of endocardial botulinum toxin injection into epicardial fat pads and intramyocardial left atrial ganglionated plexi (GP) for preventing AF.<br />Methods. Twenty-four dogs were separated into 3 groups: endocardial approach for botulinum toxin (Xeomin, Germany) injection into epicardial fat pads and intramyocardial GPs; endocardial approach for placebo injection (0.9% normal saline; control 1; n = 8) and epicardial approach for botulinum toxin injection (control 2; n = 8).<br />Results. A mean of 6.9±1.7 intramyocardial injections (10 U/0.2 mL at each) and 3 injections (50 U/1 mL at each) were administered into each site exhibiting a positive vagal response and into each epicardial fat pad in all groups (p>0.05 between groups).<br />The injections of botulinum toxin demonstrated dramatic prolongation of ERP in all PV-atrial junctions. This effect correlated with less pronounced ERP shortening in response to vagal nerve stimulation. Suppression of AF inducibility was observed at 7 days after endocardial botulinum toxin injections. The level of AF inducibility was: at 7 days – 57% (p<0.001 vs placebo; p<0.001 vs baseline); at 14 days – 61% (p<0.001 vs placebo; p<0.001 vs baseline); at 1 month – 38% (p<0.001 vs placebo; p<0.001 vs baseline); at 3 months – 23% (p = 0.003; p = 0.06 vs baseline). There were no differences between botulinum groups (p>0.05 for all). The effect of AF suppression disappeared at 3 months. No procedure-related complications occurred.<br />Conclusion. Botulinum toxin injection into intramyocardial GPs and epicardial fat pads by an endocardial approach is feasible and safe. It provides complete removal of cardiac vagal responses and reliably reduces vulnerability to atrial fibrillation.</p> |
| first_indexed | 2024-03-12T11:08:14Z |
| format | Article |
| id | doaj.art-16157a3b22c04cd093510b8602ecc8c6 |
| institution | Directory Open Access Journal |
| issn | 1681-3472 2500-3119 |
| language | English |
| last_indexed | 2024-03-12T11:08:14Z |
| publishDate | 2016-01-01 |
| publisher | Meshalkin National Medical Research Center |
| record_format | Article |
| series | Патология кровообращения и кардиохирургия |
| spelling | doaj.art-16157a3b22c04cd093510b8602ecc8c62023-09-02T03:20:54ZengMeshalkin National Medical Research CenterПатология кровообращения и кардиохирургия1681-34722500-31192016-01-011949910710.21688/1681-3472-2015-4-99-107983Endocardial botulinum toxin injection into ganglionated plexi in order to reduce atrial fibrillation inducibilityА. Г. Стрельников0А. А. Якубов1Д. С. Сергеевичев2С. Н. Артеменко3И. Л. Михеенко4С. А. Абашкин5А. Б. Романов6Е. А. Покушалов7Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15Новосибирский научно-исследовательский институт имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации, 630055, Новосибирск, ул. Речкуновская, 15<p>Objective. Prior animal studies suggest that botulinum toxin injection into the epicardial fat pads can suppress atrial fibrillation (AF) inducibility. The purpose of the present study was to assess the efficacy and safety of endocardial botulinum toxin injection into epicardial fat pads and intramyocardial left atrial ganglionated plexi (GP) for preventing AF.<br />Methods. Twenty-four dogs were separated into 3 groups: endocardial approach for botulinum toxin (Xeomin, Germany) injection into epicardial fat pads and intramyocardial GPs; endocardial approach for placebo injection (0.9% normal saline; control 1; n = 8) and epicardial approach for botulinum toxin injection (control 2; n = 8).<br />Results. A mean of 6.9±1.7 intramyocardial injections (10 U/0.2 mL at each) and 3 injections (50 U/1 mL at each) were administered into each site exhibiting a positive vagal response and into each epicardial fat pad in all groups (p>0.05 between groups).<br />The injections of botulinum toxin demonstrated dramatic prolongation of ERP in all PV-atrial junctions. This effect correlated with less pronounced ERP shortening in response to vagal nerve stimulation. Suppression of AF inducibility was observed at 7 days after endocardial botulinum toxin injections. The level of AF inducibility was: at 7 days – 57% (p<0.001 vs placebo; p<0.001 vs baseline); at 14 days – 61% (p<0.001 vs placebo; p<0.001 vs baseline); at 1 month – 38% (p<0.001 vs placebo; p<0.001 vs baseline); at 3 months – 23% (p = 0.003; p = 0.06 vs baseline). There were no differences between botulinum groups (p>0.05 for all). The effect of AF suppression disappeared at 3 months. No procedure-related complications occurred.<br />Conclusion. Botulinum toxin injection into intramyocardial GPs and epicardial fat pads by an endocardial approach is feasible and safe. It provides complete removal of cardiac vagal responses and reliably reduces vulnerability to atrial fibrillation.</p>http://journalmeshalkin.ru/index.php/heartjournal/article/view/271Фибрилляция предсердийАблацияЛегочные веныБотулинический токсинГанглионарные сплетенияАвтономная нервная система |
| spellingShingle | А. Г. Стрельников А. А. Якубов Д. С. Сергеевичев С. Н. Артеменко И. Л. Михеенко С. А. Абашкин А. Б. Романов Е. А. Покушалов Endocardial botulinum toxin injection into ganglionated plexi in order to reduce atrial fibrillation inducibility Патология кровообращения и кардиохирургия Фибрилляция предсердий Аблация Легочные вены Ботулинический токсин Ганглионарные сплетения Автономная нервная система |
| title | Endocardial botulinum toxin injection into ganglionated plexi in order to reduce atrial fibrillation inducibility |
| title_full | Endocardial botulinum toxin injection into ganglionated plexi in order to reduce atrial fibrillation inducibility |
| title_fullStr | Endocardial botulinum toxin injection into ganglionated plexi in order to reduce atrial fibrillation inducibility |
| title_full_unstemmed | Endocardial botulinum toxin injection into ganglionated plexi in order to reduce atrial fibrillation inducibility |
| title_short | Endocardial botulinum toxin injection into ganglionated plexi in order to reduce atrial fibrillation inducibility |
| title_sort | endocardial botulinum toxin injection into ganglionated plexi in order to reduce atrial fibrillation inducibility |
| topic | Фибрилляция предсердий Аблация Легочные вены Ботулинический токсин Ганглионарные сплетения Автономная нервная система |
| url | http://journalmeshalkin.ru/index.php/heartjournal/article/view/271 |
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