A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration

A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration

Abstract Articular cartilage repair and regeneration is an unmet clinical need because of the poor self-regeneration capacity of the tissue. In this study, we found that the expression of prostaglandin E receptor 4 (PTGER4 or EP4) was largely increased in the injured articular cartilage in both huma...

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Bibliographic Details
Main Authors: Yunyun Jin, Qianqian Liu, Peng Chen, Siyuan Zhao, Wenhao Jiang, Fanhua Wang, Peng Li, Yuanjin Zhang, Weiqiang Lu, Tao P. Zhong, Xinran Ma, Xin Wang, Alison Gartland, Ning Wang, Karan Mehul Shah, Hankun Zhang, Xu Cao, Lei Yang, Mingyao Liu, Jian Luo
Format: Article
Language:English
Published: Nature Publishing Group 2022-03-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00382-6

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