Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic Treatments
Siglecs are sialic acid-binding immunoglobulin-like lectins. Most Siglecs function as transmembrane receptors mainly expressed on blood cells in a cell type-specific manner. They recognize and bind sialic acids in specific linkages on glycoproteins and glycolipids. Since Sia is a self-molecule, Sigl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/5774 |
| _version_ | 1797532237719142400 |
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| author | Elena Gianchecchi Andrea Arena Alessandra Fierabracci |
| author_facet | Elena Gianchecchi Andrea Arena Alessandra Fierabracci |
| author_sort | Elena Gianchecchi |
| collection | DOAJ |
| description | Siglecs are sialic acid-binding immunoglobulin-like lectins. Most Siglecs function as transmembrane receptors mainly expressed on blood cells in a cell type-specific manner. They recognize and bind sialic acids in specific linkages on glycoproteins and glycolipids. Since Sia is a self-molecule, Siglecs play a role in innate immune responses by distinguishing molecules as self or non-self. Increasing evidence supports the involvement of Siglecs in immune signaling representing immune checkpoints able to regulate immune responses in inflammatory diseases as well as cancer. Although further studies are necessary to fully understand the involvement of Siglecs in pathological conditions as well as their interactions with other immune regulators, the development of therapeutic approaches that exploit these molecules represents a tremendous opportunity for future treatments of several human diseases, as demonstrated by their application in several clinical trials. In the present review, we discuss the involvement of Siglecs in the regulation of immune responses, with particular focus on autoimmunity and cancer and the chance to target the sialic acid-Siglec axis as novel treatment strategy. |
| first_indexed | 2024-03-10T10:56:14Z |
| format | Article |
| id | doaj.art-16183f9706e34820acfdcf7b4c29664f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T10:56:14Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-16183f9706e34820acfdcf7b4c29664f2023-11-21T21:48:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211577410.3390/ijms22115774Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic TreatmentsElena Gianchecchi0Andrea Arena1Alessandra Fierabracci2VisMederi srl, Strada del Petriccio e Belriguardo, 35, 53100 Siena, ItalyInfectivology and Clinical Trials Research Area, Bambino Gesù Children’s Hospital, IRCCS, Viale San Paolo 15, 00146 Rome, ItalyInfectivology and Clinical Trials Research Area, Bambino Gesù Children’s Hospital, IRCCS, Viale San Paolo 15, 00146 Rome, ItalySiglecs are sialic acid-binding immunoglobulin-like lectins. Most Siglecs function as transmembrane receptors mainly expressed on blood cells in a cell type-specific manner. They recognize and bind sialic acids in specific linkages on glycoproteins and glycolipids. Since Sia is a self-molecule, Siglecs play a role in innate immune responses by distinguishing molecules as self or non-self. Increasing evidence supports the involvement of Siglecs in immune signaling representing immune checkpoints able to regulate immune responses in inflammatory diseases as well as cancer. Although further studies are necessary to fully understand the involvement of Siglecs in pathological conditions as well as their interactions with other immune regulators, the development of therapeutic approaches that exploit these molecules represents a tremendous opportunity for future treatments of several human diseases, as demonstrated by their application in several clinical trials. In the present review, we discuss the involvement of Siglecs in the regulation of immune responses, with particular focus on autoimmunity and cancer and the chance to target the sialic acid-Siglec axis as novel treatment strategy.https://www.mdpi.com/1422-0067/22/11/5774siglecsialic acidautoimmunitycancertreatment |
| spellingShingle | Elena Gianchecchi Andrea Arena Alessandra Fierabracci Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic Treatments International Journal of Molecular Sciences siglec sialic acid autoimmunity cancer treatment |
| title | Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic Treatments |
| title_full | Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic Treatments |
| title_fullStr | Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic Treatments |
| title_full_unstemmed | Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic Treatments |
| title_short | Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic Treatments |
| title_sort | sialic acid siglec axis in human immune regulation involvement in autoimmunity and cancer and potential therapeutic treatments |
| topic | siglec sialic acid autoimmunity cancer treatment |
| url | https://www.mdpi.com/1422-0067/22/11/5774 |
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