Physical Approaches to Prevent and Treat Bacterial Biofilm
Prosthetic joint infection (PJI) presents several clinical challenges. This is in large part due to the formation of biofilm which can make infection eradication exceedingly difficult. Following an extensive literature search, this review surveys a variety of non-pharmacological methods of preventin...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/1/54 |
| _version_ | 1797446943876579328 |
|---|---|
| author | Alexa A. Ciarolla Norman Lapin Dustin Williams Rajiv Chopra David E. Greenberg |
| author_facet | Alexa A. Ciarolla Norman Lapin Dustin Williams Rajiv Chopra David E. Greenberg |
| author_sort | Alexa A. Ciarolla |
| collection | DOAJ |
| description | Prosthetic joint infection (PJI) presents several clinical challenges. This is in large part due to the formation of biofilm which can make infection eradication exceedingly difficult. Following an extensive literature search, this review surveys a variety of non-pharmacological methods of preventing and/or treating biofilm within the body and how they could be utilized in the treatment of PJI. Special attention has been paid to physical strategies such as heat, light, sound, and electromagnetic energy, and their uses in biofilm treatment. Though these methods are still under study, they offer a potential means to reduce the morbidity and financial burden related to multiple stage revisions and prolonged systemic antibiotic courses that make up the current gold standard in PJI treatment. Given that these options are still in the early stages of development and offer their own strengths and weaknesses, this review offers an assessment of each method, the progress made on each, and allows for comparison of methods with discussion of future challenges to their implementation in a clinical setting. |
| first_indexed | 2024-03-09T13:47:49Z |
| format | Article |
| id | doaj.art-1618a7558665466397f40a220c51c496 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T13:47:49Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-1618a7558665466397f40a220c51c4962023-11-30T20:55:03ZengMDPI AGAntibiotics2079-63822022-12-011215410.3390/antibiotics12010054Physical Approaches to Prevent and Treat Bacterial BiofilmAlexa A. Ciarolla0Norman Lapin1Dustin Williams2Rajiv Chopra3David E. Greenberg4School of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Radiology, UT Southwestern Medical Center, Dallas, TX 75390, USADepartment of Microbiology and Immunology, University of Utah School of Medicine, Salt Lake City, UT 84112, USADepartment of Radiology, UT Southwestern Medical Center, Dallas, TX 75390, USADepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USAProsthetic joint infection (PJI) presents several clinical challenges. This is in large part due to the formation of biofilm which can make infection eradication exceedingly difficult. Following an extensive literature search, this review surveys a variety of non-pharmacological methods of preventing and/or treating biofilm within the body and how they could be utilized in the treatment of PJI. Special attention has been paid to physical strategies such as heat, light, sound, and electromagnetic energy, and their uses in biofilm treatment. Though these methods are still under study, they offer a potential means to reduce the morbidity and financial burden related to multiple stage revisions and prolonged systemic antibiotic courses that make up the current gold standard in PJI treatment. Given that these options are still in the early stages of development and offer their own strengths and weaknesses, this review offers an assessment of each method, the progress made on each, and allows for comparison of methods with discussion of future challenges to their implementation in a clinical setting.https://www.mdpi.com/2079-6382/12/1/54biofilm treatmentbiofilm removalprosthetic joint infectionnon-pharmacologic methodsphysical energy |
| spellingShingle | Alexa A. Ciarolla Norman Lapin Dustin Williams Rajiv Chopra David E. Greenberg Physical Approaches to Prevent and Treat Bacterial Biofilm Antibiotics biofilm treatment biofilm removal prosthetic joint infection non-pharmacologic methods physical energy |
| title | Physical Approaches to Prevent and Treat Bacterial Biofilm |
| title_full | Physical Approaches to Prevent and Treat Bacterial Biofilm |
| title_fullStr | Physical Approaches to Prevent and Treat Bacterial Biofilm |
| title_full_unstemmed | Physical Approaches to Prevent and Treat Bacterial Biofilm |
| title_short | Physical Approaches to Prevent and Treat Bacterial Biofilm |
| title_sort | physical approaches to prevent and treat bacterial biofilm |
| topic | biofilm treatment biofilm removal prosthetic joint infection non-pharmacologic methods physical energy |
| url | https://www.mdpi.com/2079-6382/12/1/54 |
| work_keys_str_mv | AT alexaaciarolla physicalapproachestopreventandtreatbacterialbiofilm AT normanlapin physicalapproachestopreventandtreatbacterialbiofilm AT dustinwilliams physicalapproachestopreventandtreatbacterialbiofilm AT rajivchopra physicalapproachestopreventandtreatbacterialbiofilm AT davidegreenberg physicalapproachestopreventandtreatbacterialbiofilm |