An Event-Related Potential Examination of Contour Integration Deficits in Schizophrenia
Perceptual organization, which refers to the ability to integrate fragments of stimuli to form a representation of a whole edge, part, or object, is impaired in schizophrenia. A contour integration paradigm, involving detection of a set of Gabor patches forming an oval contour pointing to the right...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-03-01
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| Series: | Frontiers in Psychology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyg.2013.00132/full |
| _version_ | 1811331015227998208 |
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| author | Pamela D Butler Pamela D Butler Pamela D Butler Ilana Y Abeles Ilana Y Abeles Ilana Y Abeles Steven M Silverstein Steven M Silverstein Elisa C Dias Elisa C Dias Elisa C Dias Nicole G Weiskopf Nicole G Weiskopf Daniel C Calderone Daniel C Calderone Daniel C Calderone Pejman eSehatpour Pejman eSehatpour |
| author_facet | Pamela D Butler Pamela D Butler Pamela D Butler Ilana Y Abeles Ilana Y Abeles Ilana Y Abeles Steven M Silverstein Steven M Silverstein Elisa C Dias Elisa C Dias Elisa C Dias Nicole G Weiskopf Nicole G Weiskopf Daniel C Calderone Daniel C Calderone Daniel C Calderone Pejman eSehatpour Pejman eSehatpour |
| author_sort | Pamela D Butler |
| collection | DOAJ |
| description | Perceptual organization, which refers to the ability to integrate fragments of stimuli to form a representation of a whole edge, part, or object, is impaired in schizophrenia. A contour integration paradigm, involving detection of a set of Gabor patches forming an oval contour pointing to the right or left embedded in a field of randomly oriented Gabors, has been developed for use in clinical trials of schizophrenia. The purpose of the present study was to assess contributions of early and later stages of processing to deficits in contour integration, as well as to develop an event-related potential (ERP) analog of this task. Twenty-one patients with schizophrenia and 28 controls participated. The Gabor elements forming the contours were given a low or high degree of orientational jitter, making it either easy or difficult to identify the direction in which the contour was pointing. ERP results showed greater negative peaks at ~165 (N1 component) and ~270 ms for the low-jitter versus the high-jitter contours, with a much greater difference between jitter conditions at 270 ms. This later ERP component was previously termed Ncl for closure negativity. Source localization identified the Ncl in the lateral occipital object recognition area. Patients showed a significant decrease in the Ncl, but not N1, compared to controls, and this was associated with impaired behavioral ability to identify contours. In addition, an earlier negative peak was found at ~120 ms (termed N120) that differentiated jitter conditions, had a dorsal stream source, and differed between patients and controls. Patients also showed a deficit in the dorsal stream sensory P1 component. These results are in accord with impairments in distributed circuitry contributing to perceptual organization deficits and provide an ERP analog to the behavioral contour integration task. |
| first_indexed | 2024-04-13T16:12:30Z |
| format | Article |
| id | doaj.art-161ad1f5cf46465383665fc4f996a9cd |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-13T16:12:30Z |
| publishDate | 2013-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-161ad1f5cf46465383665fc4f996a9cd2022-12-22T02:40:10ZengFrontiers Media S.A.Frontiers in Psychology1664-10782013-03-01410.3389/fpsyg.2013.0013245930An Event-Related Potential Examination of Contour Integration Deficits in SchizophreniaPamela D Butler0Pamela D Butler1Pamela D Butler2Ilana Y Abeles3Ilana Y Abeles4Ilana Y Abeles5Steven M Silverstein6Steven M Silverstein7Elisa C Dias8Elisa C Dias9Elisa C Dias10Nicole G Weiskopf11Nicole G Weiskopf12Daniel C Calderone13Daniel C Calderone14Daniel C Calderone15Pejman eSehatpour16Pejman eSehatpour17Nathan Kline Institute for Psychiatric ResearchNew York University School of MedicineCity College of the City University of New YorkNathan Kline Institute for Psychiatric ResearchNew York University School of MedicineCity College of the City University of New YorkUniversity of Medicine and Dentistry of New Jersey -University Behavioral HealthCareUniversity of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical SchoolNathan Kline Institute for Psychiatric ResearchNew York University School of MedicineCity College of the City University of New YorkNathan Kline Institute for Psychiatric ResearchColumbia UniversityNathan Kline Institute for Psychiatric ResearchNew York University School of MedicineCity College of the City University of New YorkNathan Kline Institute for Psychiatric ResearchColumbia University College of Physicians and SurgeonsPerceptual organization, which refers to the ability to integrate fragments of stimuli to form a representation of a whole edge, part, or object, is impaired in schizophrenia. A contour integration paradigm, involving detection of a set of Gabor patches forming an oval contour pointing to the right or left embedded in a field of randomly oriented Gabors, has been developed for use in clinical trials of schizophrenia. The purpose of the present study was to assess contributions of early and later stages of processing to deficits in contour integration, as well as to develop an event-related potential (ERP) analog of this task. Twenty-one patients with schizophrenia and 28 controls participated. The Gabor elements forming the contours were given a low or high degree of orientational jitter, making it either easy or difficult to identify the direction in which the contour was pointing. ERP results showed greater negative peaks at ~165 (N1 component) and ~270 ms for the low-jitter versus the high-jitter contours, with a much greater difference between jitter conditions at 270 ms. This later ERP component was previously termed Ncl for closure negativity. Source localization identified the Ncl in the lateral occipital object recognition area. Patients showed a significant decrease in the Ncl, but not N1, compared to controls, and this was associated with impaired behavioral ability to identify contours. In addition, an earlier negative peak was found at ~120 ms (termed N120) that differentiated jitter conditions, had a dorsal stream source, and differed between patients and controls. Patients also showed a deficit in the dorsal stream sensory P1 component. These results are in accord with impairments in distributed circuitry contributing to perceptual organization deficits and provide an ERP analog to the behavioral contour integration task.http://journal.frontiersin.org/Journal/10.3389/fpsyg.2013.00132/fullCognitionElectrophysiologyPerceptionSchizophreniaVisioncontour integration |
| spellingShingle | Pamela D Butler Pamela D Butler Pamela D Butler Ilana Y Abeles Ilana Y Abeles Ilana Y Abeles Steven M Silverstein Steven M Silverstein Elisa C Dias Elisa C Dias Elisa C Dias Nicole G Weiskopf Nicole G Weiskopf Daniel C Calderone Daniel C Calderone Daniel C Calderone Pejman eSehatpour Pejman eSehatpour An Event-Related Potential Examination of Contour Integration Deficits in Schizophrenia Frontiers in Psychology Cognition Electrophysiology Perception Schizophrenia Vision contour integration |
| title | An Event-Related Potential Examination of Contour Integration Deficits in Schizophrenia |
| title_full | An Event-Related Potential Examination of Contour Integration Deficits in Schizophrenia |
| title_fullStr | An Event-Related Potential Examination of Contour Integration Deficits in Schizophrenia |
| title_full_unstemmed | An Event-Related Potential Examination of Contour Integration Deficits in Schizophrenia |
| title_short | An Event-Related Potential Examination of Contour Integration Deficits in Schizophrenia |
| title_sort | event related potential examination of contour integration deficits in schizophrenia |
| topic | Cognition Electrophysiology Perception Schizophrenia Vision contour integration |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyg.2013.00132/full |
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