Pitfalls with Vitamin D Research in Musculoskeletal Disorders and Recommendations on How to Avoid Them
Reports suggesting that vitamin D may have extraskeletal roles have renewed interest in vitamin D research and stimulated publication of an increasing number of new studies each year. These studies typically assess vitamin D status by measuring the blood concentration of 25-hydroxyvitamin D [25(OH)D...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Yayincilik
2019-09-01
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| Series: | JCRPE |
| Subjects: | |
| Online Access: |
http://www.jcrpe.org/archives/archive-detail/article-preview/pitfalls-with-vitamin-d-research-in-musculoskeleta/23621
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| _version_ | 1828021316458905600 |
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| author | Gary M. Kiebzak Kevin M. Neal Pooya Hosseinzadeh Robert C. Olney Michael A. Levine |
| author_facet | Gary M. Kiebzak Kevin M. Neal Pooya Hosseinzadeh Robert C. Olney Michael A. Levine |
| author_sort | Gary M. Kiebzak |
| collection | DOAJ |
| description | Reports suggesting that vitamin D may have extraskeletal roles have renewed interest in vitamin D research and stimulated publication of an increasing number of new studies each year. These studies typically assess vitamin D status by measuring the blood concentration of 25-hydroxyvitamin D [25(OH)D], the principal circulating metabolite of vitamin D. Unfortunately, variations in assay format, inconsistency in interpreting 25(OH)D concentrations, cohort bias (age, body mass index, race, season of measurements etc.) and failure to measure critical variables needed to interpret study results, makes interpreting results and comparing studies difficult. Further, variation in reporting results (reporting mean values vs. percent of the cohort that is deficient, no clear statement as to clinical relevance of effect size, etc.) further limits interstudy analyses. In this paper, we discuss many common pitfalls in vitamin D research. We also provide recommendations on avoiding these pitfalls and suggest guidelines to enhance consistency in reporting results. |
| first_indexed | 2024-04-10T11:50:09Z |
| format | Article |
| id | doaj.art-161b2529c3f34a1e80690778ecb41a4b |
| institution | Directory Open Access Journal |
| issn | 1308-5727 1308-5735 |
| language | English |
| last_indexed | 2024-04-10T11:50:09Z |
| publishDate | 2019-09-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | JCRPE |
| spelling | doaj.art-161b2529c3f34a1e80690778ecb41a4b2023-02-15T16:17:08ZengGalenos YayincilikJCRPE1308-57271308-57352019-09-0111322022610.4274/jcrpe.galenos.2019.2019.000713049054Pitfalls with Vitamin D Research in Musculoskeletal Disorders and Recommendations on How to Avoid ThemGary M. Kiebzak0Kevin M. Neal1Pooya Hosseinzadeh2Robert C. Olney3Michael A. Levine4 Nemours Children’s Hospital and Specialty Care, Department of Orthopedics and Sports Medicine, Florida, USA Nemours Children’s Specialty Care, Department of Orthopedic Surgery, Florida, USA Washington University Faculty of Medicine, Department of Orthopaedic Surgery, 1 Children’s Place, Missouri, USA Nemours Children’s Specialty Care, Department of Endocrinology, Florida, USA Children’s Hospital of Philadelphia, Center for Bone Health, Division of Endocrinology and Diabetes, Pennsylvania, USA Reports suggesting that vitamin D may have extraskeletal roles have renewed interest in vitamin D research and stimulated publication of an increasing number of new studies each year. These studies typically assess vitamin D status by measuring the blood concentration of 25-hydroxyvitamin D [25(OH)D], the principal circulating metabolite of vitamin D. Unfortunately, variations in assay format, inconsistency in interpreting 25(OH)D concentrations, cohort bias (age, body mass index, race, season of measurements etc.) and failure to measure critical variables needed to interpret study results, makes interpreting results and comparing studies difficult. Further, variation in reporting results (reporting mean values vs. percent of the cohort that is deficient, no clear statement as to clinical relevance of effect size, etc.) further limits interstudy analyses. In this paper, we discuss many common pitfalls in vitamin D research. We also provide recommendations on avoiding these pitfalls and suggest guidelines to enhance consistency in reporting results. http://www.jcrpe.org/archives/archive-detail/article-preview/pitfalls-with-vitamin-d-research-in-musculoskeleta/23621 Vitamin D25-hydroxyvitamin Ddeficiency |
| spellingShingle | Gary M. Kiebzak Kevin M. Neal Pooya Hosseinzadeh Robert C. Olney Michael A. Levine Pitfalls with Vitamin D Research in Musculoskeletal Disorders and Recommendations on How to Avoid Them JCRPE Vitamin D 25-hydroxyvitamin D deficiency |
| title | Pitfalls with Vitamin D Research in Musculoskeletal Disorders and Recommendations on How to Avoid Them |
| title_full | Pitfalls with Vitamin D Research in Musculoskeletal Disorders and Recommendations on How to Avoid Them |
| title_fullStr | Pitfalls with Vitamin D Research in Musculoskeletal Disorders and Recommendations on How to Avoid Them |
| title_full_unstemmed | Pitfalls with Vitamin D Research in Musculoskeletal Disorders and Recommendations on How to Avoid Them |
| title_short | Pitfalls with Vitamin D Research in Musculoskeletal Disorders and Recommendations on How to Avoid Them |
| title_sort | pitfalls with vitamin d research in musculoskeletal disorders and recommendations on how to avoid them |
| topic | Vitamin D 25-hydroxyvitamin D deficiency |
| url |
http://www.jcrpe.org/archives/archive-detail/article-preview/pitfalls-with-vitamin-d-research-in-musculoskeleta/23621
|
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