ADAM-15 Disintegrin-Like Domain Structure and Function
The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD) in it...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-10-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/2/10/2411/ |
| _version_ | 1798025948049702912 |
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| author | Dong Lu Mike Scully Vijay Kakkar Xinjie Lu |
| author_facet | Dong Lu Mike Scully Vijay Kakkar Xinjie Lu |
| author_sort | Dong Lu |
| collection | DOAJ |
| description | The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD) in its disintegrin-like domain. This motif is also found in most snake venom disintegrins and other disintegrin-like proteins. This unique RGD motif within ADAM-15 serves as an integrin ligand binding site, through which it plays a pivotal role in interacting with integrin receptors, a large family of heterodimeric transmembrane glycoproteins. This manuscript will present a review of the RGD-containing disintegrin-like domain structures and the structural features responsible for their activity as antagonists of integrin function in relation to the canonical RGD template. |
| first_indexed | 2024-04-11T18:27:11Z |
| format | Article |
| id | doaj.art-161b7236ff8f4a3386fc13846bc08177 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T18:27:11Z |
| publishDate | 2010-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-161b7236ff8f4a3386fc13846bc081772022-12-22T04:09:34ZengMDPI AGToxins2072-66512010-10-012102411242710.3390/toxins2102411ADAM-15 Disintegrin-Like Domain Structure and FunctionDong LuMike ScullyVijay KakkarXinjie LuThe ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD) in its disintegrin-like domain. This motif is also found in most snake venom disintegrins and other disintegrin-like proteins. This unique RGD motif within ADAM-15 serves as an integrin ligand binding site, through which it plays a pivotal role in interacting with integrin receptors, a large family of heterodimeric transmembrane glycoproteins. This manuscript will present a review of the RGD-containing disintegrin-like domain structures and the structural features responsible for their activity as antagonists of integrin function in relation to the canonical RGD template.http://www.mdpi.com/2072-6651/2/10/2411/ADAM proteinSnake venom toxindisintegrinintegrinRGD-motif |
| spellingShingle | Dong Lu Mike Scully Vijay Kakkar Xinjie Lu ADAM-15 Disintegrin-Like Domain Structure and Function Toxins ADAM protein Snake venom toxin disintegrin integrin RGD-motif |
| title | ADAM-15 Disintegrin-Like Domain Structure and Function |
| title_full | ADAM-15 Disintegrin-Like Domain Structure and Function |
| title_fullStr | ADAM-15 Disintegrin-Like Domain Structure and Function |
| title_full_unstemmed | ADAM-15 Disintegrin-Like Domain Structure and Function |
| title_short | ADAM-15 Disintegrin-Like Domain Structure and Function |
| title_sort | adam 15 disintegrin like domain structure and function |
| topic | ADAM protein Snake venom toxin disintegrin integrin RGD-motif |
| url | http://www.mdpi.com/2072-6651/2/10/2411/ |
| work_keys_str_mv | AT donglu adam15disintegrinlikedomainstructureandfunction AT mikescully adam15disintegrinlikedomainstructureandfunction AT vijaykakkar adam15disintegrinlikedomainstructureandfunction AT xinjielu adam15disintegrinlikedomainstructureandfunction |