Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience
Abstract Introduction Keratoacanthomas are cutaneous neoplasms known for their rapid growth and spontaneous regression over a long time period. Their treatment can be difficult because of the potentially large field size and number of lesions. Intralesional methotrexate constitutes an effective, non...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2019-02-01
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| Series: | Dermatology and Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13555-019-0286-1 |
| _version_ | 1819051158425042944 |
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| author | Massimiliano Scalvenzi Angela Patrì Claudia Costa Matteo Megna Maddalena Napolitano Gabriella Fabbrocini Nicola Balato |
| author_facet | Massimiliano Scalvenzi Angela Patrì Claudia Costa Matteo Megna Maddalena Napolitano Gabriella Fabbrocini Nicola Balato |
| author_sort | Massimiliano Scalvenzi |
| collection | DOAJ |
| description | Abstract Introduction Keratoacanthomas are cutaneous neoplasms known for their rapid growth and spontaneous regression over a long time period. Their treatment can be difficult because of the potentially large field size and number of lesions. Intralesional methotrexate constitutes an effective, nonsurgical treatment of keratoacanthomas, as proven by our experience. Methods We treated 11 elderly patients affected by keratoacanthoma with intralesional methotrexate. The injections were performed weekly, followed by 10 mg of folic acid to be taken 24 h later. Results All our patients underwent complete resolution of the lesions after 4–8 injections, without side effects. Conclusion Intralesional methotrexate seems to be an effective and safe nonoperative treatment modality for keratoacanthoma, especially when it arises in anatomic areas difficult to treat with surgery, in elderly debilitated patients, and in those refusing surgery. |
| first_indexed | 2024-12-21T11:59:29Z |
| format | Article |
| id | doaj.art-161dbd69682f4db586bf011bb661c344 |
| institution | Directory Open Access Journal |
| issn | 2193-8210 2190-9172 |
| language | English |
| last_indexed | 2024-12-21T11:59:29Z |
| publishDate | 2019-02-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Dermatology and Therapy |
| spelling | doaj.art-161dbd69682f4db586bf011bb661c3442022-12-21T19:04:51ZengAdis, Springer HealthcareDermatology and Therapy2193-82102190-91722019-02-019236937210.1007/s13555-019-0286-1Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan ExperienceMassimiliano Scalvenzi0Angela Patrì1Claudia Costa2Matteo Megna3Maddalena Napolitano4Gabriella Fabbrocini5Nicola Balato6Department of Dermatology, University of Naples Federico IIDepartment of Dermatology, University of Naples Federico IIDepartment of Dermatology, University of Naples Federico IIDepartment of Dermatology, University of Naples Federico IIDepartment of Medicine and Health Sciences Vincenzo Tiberio, University of MoliseDepartment of Dermatology, University of Naples Federico IIDepartment of Dermatology, University of Naples Federico IIAbstract Introduction Keratoacanthomas are cutaneous neoplasms known for their rapid growth and spontaneous regression over a long time period. Their treatment can be difficult because of the potentially large field size and number of lesions. Intralesional methotrexate constitutes an effective, nonsurgical treatment of keratoacanthomas, as proven by our experience. Methods We treated 11 elderly patients affected by keratoacanthoma with intralesional methotrexate. The injections were performed weekly, followed by 10 mg of folic acid to be taken 24 h later. Results All our patients underwent complete resolution of the lesions after 4–8 injections, without side effects. Conclusion Intralesional methotrexate seems to be an effective and safe nonoperative treatment modality for keratoacanthoma, especially when it arises in anatomic areas difficult to treat with surgery, in elderly debilitated patients, and in those refusing surgery.http://link.springer.com/article/10.1007/s13555-019-0286-1KeratoacanthomaMethotrexateNonsurgical treatment |
| spellingShingle | Massimiliano Scalvenzi Angela Patrì Claudia Costa Matteo Megna Maddalena Napolitano Gabriella Fabbrocini Nicola Balato Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience Dermatology and Therapy Keratoacanthoma Methotrexate Nonsurgical treatment |
| title | Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience |
| title_full | Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience |
| title_fullStr | Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience |
| title_full_unstemmed | Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience |
| title_short | Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience |
| title_sort | intralesional methotrexate for the treatment of keratoacanthoma the neapolitan experience |
| topic | Keratoacanthoma Methotrexate Nonsurgical treatment |
| url | http://link.springer.com/article/10.1007/s13555-019-0286-1 |
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